Berberine Alleviates Paclitaxel-Induced Neuropathy
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
bjectives: Paclitaxel (PTX) as an anticancer drug used against solid cancers, possesses adverse reactions such as neuropathic pain which has confined its use. PTX-induced neuropathic pain is mediated via activation of oxidative stress. Berberine (BER), an isoquinoline phytochemical found in several plants, exerts strong antioxidant and painkilling properties. In the current study, we aimed to evaluate pain-relieving effect of BER in a mouse model of PTX-induced neuropathic pain. Methods: This study was done using 42 male albino mice that were randomly divided into 6 groups (n = 7) as follow: Sham-operated (not treated with PTX), negative control group (PTX-treated mice receiving normal saline), BER 5, 10, and 20 mg/kg (PTX-treated mice receiving BER) and positive control group (PTX-treated mice receiving imipramine 10 mg/kg). Neuropathic pain was induced by intraperitoneal administration of four doses of PTX (2 mg/kg/day) on days 1, 3, 5 and 7. Then, on day7, hot plate test was done to assess latency to heat to measure possible anti-neuropathic pain effect of BER. Results: Four doses of PTX 2 mg/kg/day induced neuropathy that was reduced by BER at all time-points (i.e. 0, 30, 60, 90 and 120 min) after injection (P < 0.001 in comparison to control). The statistical analysis of data showed significant differences between groups (P < 0.001 in comparison to negative control), at 30, 60, 90 and 120 min after injection of BER 5, 10 and 20 mg/ kg; in other words, 30, 60, 90 and 120 min after BER administration, neuropathic pain was significantly reduced as compared to normal saline-treated mice. Conclusion: Altogether, our results showed that PTX could induce neuropathic pain as reflected by hyperalgesia and BER could alleviate PTX-induced thermal hyperalgesia.
Abstract
bjectives: Paclitaxel (PTX) as an anticancer drug used against solid cancers, possesses adverse reactions such as neuropathic pain which has confined its use. PTX-induced neuropathic pain is mediated via activation of oxidative stress. Berberine (BER), an isoquinoline phytochemical found in several plants, exerts strong antioxidant and painkilling properties. In the current study, we aimed to evaluate pain-relieving effect of BER in a mouse model of PTX-induced neuropathic pain. Methods: This study was done using 42 male albino mice that were randomly divided into 6 groups (n = 7) as follow: Sham-operated (not treated with PTX), negative control group (PTX-treated mice receiving normal saline), BER 5, 10, and 20 mg/kg (PTX-treated mice receiving BER) and positive control group (PTX-treated mice receiving imipramine 10 mg/kg). Neuropathic pain was induced by intraperitoneal administration of four doses of PTX (2 mg/kg/day) on days 1, 3, 5 and 7. Then, on day7, hot plate test was done to assess latency to heat to measure possible anti-neuropathic pain effect of BER. Results: Four doses of PTX 2 mg/kg/day induced neuropathy that was reduced by BER at all time-points (i.e. 0, 30, 60, 90 and 120 min) after injection (P < 0.001 in comparison to control). The statistical analysis of data showed significant differences between groups (P < 0.001 in comparison to negative control), at 30, 60, 90 and 120 min after injection of BER 5, 10 and 20 mg/ kg; in other words, 30, 60, 90 and 120 min after BER administration, neuropathic pain was significantly reduced as compared to normal saline-treated mice. Conclusion: Altogether, our results showed that PTX could induce neuropathic pain as reflected by hyperalgesia and BER could alleviate PTX-induced thermal hyperalgesia.
참고문헌 (43)
- Wilson L, "New microtubule", tubulin-targeted anticancer drugs and novel chemotherapeutic strategies, 2013, ~
- Lee JJ, "Peripheral neuropathy induced by microtubule-stabilizing agents", Journal of Clinical Oncology, 24, pp.1633~1642 (2006)
- Park S, "Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies", Current medicinal chemistry, 15, pp.3081~3094 (2008)
- Cliffer KD, "Physiological characterization of Taxol-induced large-fiber sensory neuropathy in the rat", Annals of neurology, 43, pp.46~55 (1998)
- Polomano RC, "A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel", Pain, 94, pp.293~304 (2001)
- Flatters SJ, "Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy : evidence for mitochondrial dysfunction", Pain, 122, pp.245~257 (2006)
- Liu C-C, "Prevention of paclitaxel-induced allodynia by minocycline : effect on loss of peripheral nerve fibers and infiltration of macrophages in rats", Molecular pain, 6, pp.76~ (2010)
- Naguib M, "Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system", Anesthesia and analgesia, 114, pp.1104~ (2012)
- Kosalec I, "Croatian barberry(Berberis croatica Horvat) : A new source of berberine-Analysis and antimicrobial activity", World Journal of Microbiology and Biotechnology, 25(1), pp.145~150 (2009)
- Chang Y, "Effectiveness of berberine in bacillary dysentery", Zhonghua nei ke za zhi, 7, pp.741~743 (1959)
- Xia X, "Assessment of the anti-diarrhea function of compound Chinese herbal medicine cangpo oral liquid", African Journal of Traditional, Complementary and Alternative Medicines, 11, pp.140~147 (2013)
- Jiang X-W, "Effects of berberine gelatin on recurrent aphthous stomatitis : a randomized, placebo-controlled, double-blind trial in a Chinese cohort", Oral surgery, oral medicine, oral pathology and oral radiology, 115, pp.212~217 (2013)
- Li HL, "Alkaloids from Corydalis saxicola and Their Anti-Hepatitis B Virus Activity", Chemistry & biodiversity, 5, pp.777~783 (2008)
- Yao J, "Learning from berberine : Treating chronic diseases through multiple targets", Science China Life Sciences, 58, pp.854~859 (2015)
- Wu H-L, "Berberine inhibits the proliferation of human uterine leiomyoma cells", Fertility and sterility, 103, pp.1098~1106 (2015)
- Refaat A, "Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine", tumor necrosis factor-related apoptosis-inducing ligand combination therapy, 2015, pp.10, 1907~1911
- Liu Y-T, "Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats", Drug metabolism and disposition, 38, pp.1779~1784 (2010)
- Peng W-H, "Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models : interaction with drugs acting at 5-HT receptors", Life Sciences, 75, pp.2451~2462 (2004)
- Lou T, "Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes", Inflammation, 34, pp.659~667 (2011)
- 최봉혁, "Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte", Experimental and Molecular Medicine, 38(6), pp.599~605 (2006), 생화학분자생물학회
- Wu M, "Advance of studies on anti-atherosclerosis mechanism of berberine", Chinese journal of integrative medicine, 16, pp.188~192 (2010)
- Gu L, "Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia", Journal of Infectious Diseases, 203, pp.1602~1612 (2011)
- Jeong HW, "Berberine suppresses proinflammatory responses through AMPK activation in macrophages", American Journal of Physiology-Endocrinology and Metabolism, 296, pp.E955~E964 (2009)
- Toma W, "Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse", Neuropharmacology, 117, pp.305~315 (2017)
- Segat GC, "Antiallodynic effect of beta-caryophyllene on paclitaxel-induced peripheral neuropathy in mice", Neuropharmacology, 125, pp.207~219 (2017)
- 김시오, "Berberine Ameliorates Cold and Mechanical Allodynia in a Rat Model of Diabetic Neuropathy", Journal of Medicinal Food, 16(6), pp.511~517 (2013), 한국식품영양과학회[DOI]
- Mojarad TB, "The anticonvulsant and antioxidant effects of berberine in kainate-induced temporal lobe epilepsy in rats", Basic and clinical neuroscience, 5, pp.124~ (2014)
- Wani MC, "Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia", Journal of the American Chemical Society, 93, pp.2325~2327 (1971)
- Flatters SJ, "Ethosuximide reverses paclitaxel-and vincristine-induced painful peripheral neuropathy", Pain, 109, pp.150~161 (2004)
- Komal S, "Berberis aristata : A review", Int J Res Ayurveda Pharm, 2, pp.383~388 (2011)
- Kumar A, "Current knowledge and pharmacological profile of berberine : an update", European journal of pharmacology, 761, pp.288~297 (2015)
- Liu C-S, "Research progress on berberine with a special focus on its oral bioavailability", Fitoterapia, 109, pp.274~282 (2016)
- Lan J, "Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension", Journal of ethnopharmacology, 161, pp.69~81 (2015)
- Wang N, "Berberine and Coptidis Rhizoma as potential anticancer agents : Recent updates and future perspectives", Journal of ethnopharmacology, 176, pp.35~48 (2015)
- Imenshahidi M, "Inhibitory effect of berberis vulgaris aqueous extract on acquisition and reinstatement effects of morphine in conditioned place preferences (CPP) in mice", Jundishapur journal of natural pharmaceutical products, 9(3), pp.e16145~ (2014)
- Hassani FV, "Effects of berberine on acquisition and reinstatement of morphine-induced conditioned place preference in mice", Avicenna journal of phytomedicine, 6(2), pp.198~204 (2016)
- Alexandre J, "Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir", Journal of the National Cancer Institute, 98, pp.236~244 (2006)
- Barbosa-Filho JM, "Anti-inflammatory activity of alkaloids : A twenty-century review", Revista Brasileira de Farmacognosia, 16, pp.109~139 (2006)
- Sack RB, "Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins", Infection and immunity, 35, pp.471~475 (1982)
- Tsai C, "Pharmacological effects of berberine on the longitudinal muscle of the guinea-pig isolated ileum", Archives internationales de pharmacodynamie et de thérapie, 310, pp.116~131 (1990)
- Kaeidi A, "Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: in vitro and in vivo studies", Journal of ethnopharmacology, 136, pp.188~196 (2011)
- Shirwaikar A, "In vitro antioxidant studies on the benzyl tetra isoquinoline alkaloid berberine", Biological and Pharmaceutical Bulletin, 29, pp.1906~1910 (2006)
- Jiang W, "Therapeutic effect of berberine on Huntington’s disease transgenic mouse model", PLoS One, 10, pp.e0134142~ (2015)