Preventive Effects of Fluoride Gel Application on Dental Caries in the Permanent Tooth: A Systematic Review of Randomized Controlled Trials
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Background: The purpose of this systematic review was to investigate the effects of topical fluoride gel application on dental caries prevention in the permanent teeth of children and adolescents. Methods: We searched the EMBASE, PubMed, and Cochrane Library databases for randomized controlled trials (RCTs) assessing the effects of self-applied or professionally applied topical fluoride gels in patients <18 years of age; the search was completed on April 1, 2018. All included trials involved an experimental group (fluoride gel application) and a control group (placebo or no treatment). The outcome measures were the D(M)FS and D(M)FT indices, which were compared between the two groups. Review Manager software was used for quantitative synthesis of the final selected articles, and a forest plot was generated via a meta-analysis conducted using a random effects model. Results: The results showed that the D(M)FS and D(M)FT indices were lower in the fluoride application group than in the control group, thus indicating that fluoride gel application was effective in dental caries prevention. We also performed a subgroup analysis to determine whether the effects of fluoride application differed if patients received oral prophylaxis (self or professional) before fluoride gel application. Therefore, the two groups showed slightly larger differences when studies without oral prophylaxis before fluoride gel application were considered; however, the difference was not statistically significant. Conclusion: These findings should be utilized to raise awareness about the caries-prevention effects of topical fluoride application among patients and guardians. Further RCTs should evaluate the effects of fluoride application with or without preceding oral prophylaxis, and appropriate fluoride application guidelines should be developed to maximize the effects of fluoride application in clinical practice.
Abstract
Background: The purpose of this systematic review was to investigate the effects of topical fluoride gel application on dental caries prevention in the permanent teeth of children and adolescents. Methods: We searched the EMBASE, PubMed, and Cochrane Library databases for randomized controlled trials (RCTs) assessing the effects of self-applied or professionally applied topical fluoride gels in patients <18 years of age; the search was completed on April 1, 2018. All included trials involved an experimental group (fluoride gel application) and a control group (placebo or no treatment). The outcome measures were the D(M)FS and D(M)FT indices, which were compared between the two groups. Review Manager software was used for quantitative synthesis of the final selected articles, and a forest plot was generated via a meta-analysis conducted using a random effects model. Results: The results showed that the D(M)FS and D(M)FT indices were lower in the fluoride application group than in the control group, thus indicating that fluoride gel application was effective in dental caries prevention. We also performed a subgroup analysis to determine whether the effects of fluoride application differed if patients received oral prophylaxis (self or professional) before fluoride gel application. Therefore, the two groups showed slightly larger differences when studies without oral prophylaxis before fluoride gel application were considered; however, the difference was not statistically significant. Conclusion: These findings should be utilized to raise awareness about the caries-prevention effects of topical fluoride application among patients and guardians. Further RCTs should evaluate the effects of fluoride application with or without preceding oral prophylaxis, and appropriate fluoride application guidelines should be developed to maximize the effects of fluoride application in clinical practice.
참고문헌 (36)
- Marinho VC, "Fluoride gels for preventing dental caries in children and adolescents", Cochrane Database Syst Rev, 6, pp.CD002280~ (2015)[DOI]
- G.J. Truin, "Professionally Applied Fluoride Gel in Low-caries 10.5-year-olds", Journal of Dental Research, 84(5), pp.418~421 (2016), SAGE Publications[DOI]
- ten Cate JM, "Current concepts on the theories of the mechanism of action of fluoride", Acta Odontol Scand, 57, pp.325~329 (1999)
- 정의연, "인천시 초등생 어머니의 수돗물불소농도조정사업 찬반의견 및 관련요인", 치위생과학회지, 13(1), pp.29~35 (2013), 한국치위생과학회
- H.M. van Rijkom, "Caries-Inhibiting Effect of Professional Fluoride Gel Application in Low-Caries Children Initially Aged 4.5–6.5 Years", Caries Research, 38(2), pp.115~123 (2004), S. Karger AG[DOI]
- Maria Laura Menezes Bonow, "Efficacy of 1.23% APF gel applications on incipient carious lesions: a double-blind randomized clinical trial", Brazilian Oral Research, 27(3), pp.279~285 (2013), FapUNIFESP (SciELO)[DOI]
- Agrawal N, "Feasibility of including APF gel application in a school oral health promotion program as a caries-preventive agent: a community intervention trial", J Oral Sci, 53, pp.185~191 (2011)
- DePaola PF, "The anticaries effect of single and combined topical fluoride systems in school children", Arch Oral Biol, 25, pp.649~653 (1980)
- Han Jiang, "Effect of professional application of APF foam on caries reduction in permanent first molars in 6–7-year-old children: 24-month clinical trial", Journal of Dentistry, 33(6), pp.469~473 (2005), Elsevier BV[DOI]
- Peter J. Mainwaring, "A Three-Year Clinical Study to Determine the Separate and Combined Caries-Inhibiting Effects of Sodium Monofluorophosphate Toothpaste and an Acidulated Phosphate-Fluoride Gel", Caries Research, 12(4), pp.202~212 (1978), S. Karger AG[DOI]
- Splieth CH, "Efficacy of semiannual topical fluoride application in schoolchildren", Quintessence Int, 42, pp.753~760 (2011)
- Englander HR, "Incremental rates of dental caries after repeated topical sodium fluoride applications in children with lifelong consumption of fluoridated water", J Am Dent Assoc, 82, pp.354~358 (1971)
- Olivier M, "Efficacy of APF treatments without prior toothcleaning targeted to high-risk children", Community Dent Oral Epidemiol, 20, pp.38~42 (1992)
- Shern RJ, "Clinical study of an amine fluoride gel and acidulated phosphate fluoride gel", Community Dent Oral Epidemiol, 4, pp.133~136 (1976)
- Bryan ET, "The cariostatic effectiveness of a phosphate-fluoride gel administered annually to school children; final results", J Public Health Dent, 30, pp.13~16 (1970)
- Cons NC, "Albany topical fluoride study", J Am Dent Assoc, 80, pp.777~781 (1970)
- Hagan PP, "The caries-preventive effects of full- and half-strength topical acidulated phosphate fluoride", Pediatr Dent, 7, pp.185~191 (1985)
- Horowitz HS, "The effect on dental caries of topically applied acidulated phosphate-fluoride: results after three years", J Am Dent Assoc, 82, pp.359~365 (1971)
- Trubman A, "Effect on dental caries of self-application of acidulated phosphate fluoride paste and gel", J Am Dent Assoc, 86, pp.153~157 (1973)
- Englander HR, "Residual anticaries effect of repeated topical sodium fluoride applications by mouthpieces", J Am Dent Assoc, 78, pp.783~787 (1969)
- Vrbic V, "A 3-year study among Yugoslavian schoolchildren on caries reduction after topical application of 4% NaF-PO4", Community Dent Oral Epidemiol, 2, pp.163~165 (1974)
- J. P. T. Higgins, "The Cochrane Collaboration's tool for assessing risk of bias in randomised trials", BMJ, 343(oct18 2), pp.d5928~d5928 (2011), BMJ[DOI]
- Do KY, "Association between excessive Internet use and oral health behaviors of Korean adolescents:a 2015 national survey", Community Dent Health, 34, pp.183~189 (2017)[DOI]
- Ferreira MA, "Effect of regular fluoride gel application on incipient carious lesions", Oral Health Prev Dent, 3, pp.141~149 (2005)
- 도경이, "우리나라 청소년의 건강위험요인이 구강건강에 미치는 영향", 치위생과학회지, 16(3), pp.193~199 (2016), 한국치위생과학회
- Miller FY, "Topical fluoride for preventing dental caries in children and adolescents", Curr Pharm Des, 18, pp.5532~5541 (2012)
- 장선옥, "불소 도포 방법과 적용 횟수에 따른 법랑질의 표면 특성", 치위생과학회지, 11(2), pp.69~76 (2011), 한국치위생과학회
- O'Mullane DM, "Fluoride and oral health", Community Dent Health, 33, pp.69~99 (2016)
- E. Stokes, "Randomised Controlled Trial of the Efficacy of a High-Fluoride Gel Self-Applied by Toothbrushing in Children at High Caries Risk", Caries Research, 45(5), pp.475~485 (2011), S. Karger AG[DOI]
- Si Y, "Comprehensive oral health care to reduce the incidence of severe early childhood caries (s-ECC) in urban China", Chin J Dent Res, 19, pp.55~63 (2016)[DOI]
- Marthaler TM, "The effect of a fluoride gel used for supervised toothbrushing 15 or 30 times per year", Helv Odontol Acta, 14, pp.67~77 (1970)
- Treide A, "Caries limiting effectiveness of newly developed fluoride-containing gels after 3 years clinical use in preschool years", Stomatol DDR, 38, pp.708~712 (1988)
- H. Jiang, "The Effect of a Bi-annual Professional Application of APF Foam on Dental Caries Increment in Primary Teeth: 24-month Clinical Trial", Journal of Dental Research, 84(3), pp.265~268 (2016), SAGE Publications[DOI]
- Andruskeviciene V, "Oral health status and effectiveness of caries prevention programme in kindergartens in Kaunas city(Lithuania)", Oral Health Prev Dent, 6, pp.343~348 (2008)
- Anne Maguire, "ADA clinical recommendations on topical fluoride for caries prevention", Evidence-Based Dentistry, 15(2), pp.38~39 (2014), Springer Science and Business Media LLC[DOI]
- Sherry Shiqian Gao, "Caries remineralisation and arresting effect in children by professionally applied fluoride treatment – a systematic review", BMC Oral Health, 16(1) (2016), Springer Science and Business Media LLC[DOI]
