Anthelmintic and Analgesic Activities of Trachyspermum Khasianum H. Wolff
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Objectives: Trachyspermum khasianum H. Wolff is a rare medicinal plant characteristical-ly used by the traditional healers in traditional medicine for the treatment of throat-pain, toothache, and stomach ache. The study was designed to determine the anthelmintic and analgesic properties of the aerial parts of Trachyspermum khasianum H. Wolff (Family:Apiaceae). The aqueous and ethanol extract of T. khasianum H. Wolff was prepared and subjected for evaluation to determine the possible therapeutic effects. Methods: Anthelmintic activities of the extracts were determined by observing the time taken to paralyze and the time taken for the death of earthworms (Eisenia foetida) as compared to the standard drug–Albendazole (20 mg/ml) and control. Analgesic potential of the extracts was evaluated using Eddy’s hot plate method to understand the analgesic activity in rats (Wistar rats) at 100 mg/kg and 200 mg/kg body weight doses and com-pared with the standard reference (Diclofenac sodium: 10 mg/kg of animals). Results: The extracts showed a significant dose-dependent anthelmintic effect at the dif-ferent concentrations (10, 20, and 40) mg/ml, compared to that of the standard drug (20 mg/ml). Also, the results suggested that the plant extracts possess significantly analgesic activity in rats. Conclusion: The studies indicate that Trachyspermum khasianum shows anthelmintic andpotent analgesic activities. Further research should be carried out to identify the specific phytoconstituents responsible for both analgesic and anthelmintic activities and its pos-sible mechanism of action.
Abstract
Objectives: Trachyspermum khasianum H. Wolff is a rare medicinal plant characteristical-ly used by the traditional healers in traditional medicine for the treatment of throat-pain, toothache, and stomach ache. The study was designed to determine the anthelmintic and analgesic properties of the aerial parts of Trachyspermum khasianum H. Wolff (Family:Apiaceae). The aqueous and ethanol extract of T. khasianum H. Wolff was prepared and subjected for evaluation to determine the possible therapeutic effects. Methods: Anthelmintic activities of the extracts were determined by observing the time taken to paralyze and the time taken for the death of earthworms (Eisenia foetida) as compared to the standard drug–Albendazole (20 mg/ml) and control. Analgesic potential of the extracts was evaluated using Eddy’s hot plate method to understand the analgesic activity in rats (Wistar rats) at 100 mg/kg and 200 mg/kg body weight doses and com-pared with the standard reference (Diclofenac sodium: 10 mg/kg of animals). Results: The extracts showed a significant dose-dependent anthelmintic effect at the dif-ferent concentrations (10, 20, and 40) mg/ml, compared to that of the standard drug (20 mg/ml). Also, the results suggested that the plant extracts possess significantly analgesic activity in rats. Conclusion: The studies indicate that Trachyspermum khasianum shows anthelmintic andpotent analgesic activities. Further research should be carried out to identify the specific phytoconstituents responsible for both analgesic and anthelmintic activities and its pos-sible mechanism of action.
참고문헌 (32)
- Dwivedi SN, "Phytochemistry, pharmacological studies and traditional benefits of Trachyspermum ammi (Linn.) Sprague", Int J Pharm Life Sci, 3(5), pp.1705~1709 (2012)
- Singh RK, "Lectotypification of four species of Indian Trachyspermum(Apiaceae)", Telopea J Plant Syst, 18, pp.247~253 (2015)
- Goswami P, "Pharmacognostical and preliminary phytochemical screening of leave of Polygonum muricatum", Int J Res Pharm Pharm Sci, 2(3), pp.6~10 (2017)
- Srivastava B, "Evaluation for substitution of stem bark with small branches of Myrica esculenta for medicinal use-a comparative phytochemical study", J Ayurveda Integr Med, 7(4), pp.218~223 (2016)
- Nisha Raj RS, "Pharmacognostic and physicochemical analysis on the leaves of Brunfelsia americana L", Asian Pac J Trop Biomed, 2(Suppl 1), pp.S305~S307 (2012)
- Yousaf S, "Pharmacological and phytochemical analysis of Bergenia ciliata leaf and rhizome extracts", Pak J Pharm Sci, 31(5), pp.1911~1916 (2018)
- Gopalakrishnan S, "Pharmacognostical and physicochemical analysis of the bark of Bauhinia tomentosa L", EJ Chem, 9(2), pp.1022~1028 (2012)
- Ukwubile CA, "Analgesic and anti-inflammatory activity of Physalis angulata Linn. (Solanaceae) leaf methanolic extract in Swiss albino mice", Int Biol Biomed J, 2(4), pp.167~170 (2016)
- Esther J, "In vitro anthelmintic activity of Achyranthes aspera Linn. (Whole Plant)against Pheretima posthuma", J Res Sid Med, 1(1), pp.68~71 (2018)
- Oliveira AF, "Anthelmintic activity of plant extracts from Brazilian savanna", Vet Parasitol, 236, pp.121~127 (2017)
- Agrahari AK, "Assessment of anthelmintic activity of Jussiaea hyssopifolia G. Don", Asian J Plant Sci Res, 1(4), pp.87~91 (2011)
- Gnaneswari K, "In vitro anthelmintic activity of Leonotis nepetiifolia (L.) R.Br., a potential medicinal plant", J Chem Pharm Res, 5(2), pp.345~348 (2013)
- Pratap Chandran R, "Analysis of phytochemical constituents and anthelmintic activity of leaf extracts of Mimosa pudica L", Asian J Biomed Pharm Sci, 8(65), pp.1~5 (2018)
- Koorse KG, "Anthelmintic activity of fruit extract and fractions of Piper longum L. In vitro", Pharmacogn J, 10(2), pp.333~340 (2018)
- Bhattacharya A, "Analgesic effect of ethanolic leaf extract of Moringa oleifera on albino mice", Indian J Pain, 28(2), pp.89~94 (2014)
- Venkatachalam D, "Evaluation of analgesic activity of ethanolic and aqueous extracts of leaf of Plumeria rubra in albino rat", Pharm Biol Eval, 5(2), pp.52~58 (2018)
- Zulfiker AHM, "In vivo analgesic activity of ethanolic extracts of two medicinal plants- Scoparia dulcis L. and Ficus racemosa Linn", Biol Med, 2(2), pp.42~48 (2010)
- Khanum S, "In vivo neurological, analgesic and in vitro antioxidant and cytotoxic activities of ethanolic extract of leaf and stem bark of Wedelia chinensis", Bangladesh Pharm J, 22(1), pp.18~26 (2019)
- Azwanida NN, "A review on the extraction methods use in medicinal plants, principle, strength and limitation", Med Aromat Plants, 4(3), pp.1000196~ (2015)
- Duvey BK, "Evaluation of phytochemical constituents and anthelmintic activity of aerial part of Trichosanthes tricaspidata Lour", Int J Pharm Phytopharm Res, 3(2), pp.104~106 (2013)
- Rajareddy A, "Synthesis, characterization, and anthelmintic activity of novel benzothiazole derivatives containing indole moieties", Asian J Pharm Clin Res, 12(3), pp.321~325 (2019)
- Husori DI, "In vitro anthelmintic activity of Acanthus ilicifolius leaves extracts on Ascaridia galli and Pheretima posthuma", J Appl Pharm Sci, 8(2), pp.164~167 (2018)
- Sambodo P, "In vitro potential anthelmintic activity of Biophytum petersianum on Haemonchus contortus", Vet World, 11(1), pp.1~4 (2018)
- Shekhawat N, "Anthelmintic activity of extracts of some medicinal plants", Int J Comput Sci Math, 3(2), pp.183~187 (2011)
- James O, "In-vitro anthelmintic activity of Saba Florida(Benth)extracts against Nigerian adult earth worm(Terrestris lumbricoides)", Am J Phytomed Clin Ther, 2(6), pp.758~766 (2014)
- Das SK, "Cytotoxic, anthelmintic and analgesic activities of methanol extracts from different plant parts of Tabernaemontana corymbosa(Family : Apocynaceae)", Int J Life Sci Eng, 1(4), pp.202~206 (2015)
- Dutta S, "Analgesic and anthelmintic activity of various extracts of Andrographis panaculata Nees. stem", Int J Pharm Pharm Sci, 6(Suppl 2), pp.115~118 (2014)
- Kumar Paliwal S, "Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke", J Tradit Complement Med, 7(4), pp.532~537 (2016)
- Bhalke RD, "Analgesic and CNS depressant activities of extracts of Annona reticulata Linn. bark", Phytopharmacology, 1(5), pp.160~165 (2011)
- Ganeshpurkar A, "Experimental evaluation of analgesic and anti-inflammatory potential of Oyster mushroom Pleurotus florida", Indian J Pharmacol, 45(1), pp.66~70 (2013)
- Moniruzzaman M, "Antioxidant, antimicrobial, anti-diarrheal and analgesic activities of Diospyros malabarica (Desr.) Kostel", Bangladesh Pharm J, 22(1), pp.27~33 (2019)
- Girme AS, "Analgesic, CNS depressant and anthelmintic activity of Sarcostemma viminale", Iran J Pharmacol Ther, 7(2), pp.153~156 (2008)