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B형간염과 연관된 간세포암종의 근치적 절제술 후 혈관내피성장인자 아형의 발현양상 및 예후와의 관계

Expression of vascular endothelial growth factor (VEGF) family members and prognosis after hepatic resection in HBV-related hepatocellular carcinoma

최규성|천재민|박재범|권준혁|김성주|조재원|김종만|문주익|정금오
대한간학회 (The korean Association for the Study of the Liver)|2008.06|Clinical and Molecular Hepatology|제14권 제2호|pp. 185-196

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키워드

재발Carcinoma예후혈관내피성장인자간세포암종

초록

Background/Aims: Human hepatocellular carcinoma (HCC) is a hypervascular tumor, and vascular endothelial growth factor (VEGF) plays a key role in the regulation of tumor-associated angiogenesis. In this study, we analyzed the significance of the expression of VEGF family members on the prognosis and clinicopathologic progress of HCC. Methods: Surgically resected specimens of HCC and noncancerous liver tissue were obtained from 323 patients with HCC, and VEGF mRNA was examined by quantitative reverse transcriptase-polymerase chain reactions (RT-PCRs). Patients who were seropositive for hepatitis B surface antigen were selected for the analysis (n=208). The VEGFtumor/GAPDH (glyceraldehyde-3-phosphate dehydrogenase)tumor/VEGFnontumor/GAPDHnontumor ratio was calculated using a quantitative RT-PCR assay, and the relationships between the expressions of VEGF family members and clinicopathologic parameters were analyzed to evaluate their significance in the prognosis of HCC. Results: The disease-free survival was significantly worse in the high-VEGF-A group than in the low-VEGF-A group (P=0.035), whereas VEGF-A expression was not significantly related to overall survival (P=0.172). The factors significantly related to poor prognosis in univariate analysis were tumor size, portal vein invasion, microvascular thrombi, intrahepatic metastasis, tumor capsule invasion, liver capsule invasion, preoperative serum albumin level, and VEGF-A ratio. Multivariate analysis showed that a poor prognosis in HCC patients was significantly related to portal vein invasion (hazard ratio=3.381, P<0.001), intrahepatic metastasis (hazard ratio=2.379, P<0.001), tumor size (hazard ratio=1.834, P=0.003), and preoperative serum albumin level (hazard ratio=2.050, P=0.006). Conclusions: Our study showed that the expression of VEGF-A is positively correlated with the recurrence rate of HCC after curative resection. Therefore, a high expression of VEGF-A might be predictive of HCC recurrence after curative resection.

Abstract

Background/Aims: Human hepatocellular carcinoma (HCC) is a hypervascular tumor, and vascular endothelial growth factor (VEGF) plays a key role in the regulation of tumor-associated angiogenesis. In this study, we analyzed the significance of the expression of VEGF family members on the prognosis and clinicopathologic progress of HCC. Methods: Surgically resected specimens of HCC and noncancerous liver tissue were obtained from 323 patients with HCC, and VEGF mRNA was examined by quantitative reverse transcriptase-polymerase chain reactions (RT-PCRs). Patients who were seropositive for hepatitis B surface antigen were selected for the analysis (n=208). The VEGFtumor/GAPDH (glyceraldehyde-3-phosphate dehydrogenase)tumor/VEGFnontumor/GAPDHnontumor ratio was calculated using a quantitative RT-PCR assay, and the relationships between the expressions of VEGF family members and clinicopathologic parameters were analyzed to evaluate their significance in the prognosis of HCC. Results: The disease-free survival was significantly worse in the high-VEGF-A group than in the low-VEGF-A group (P=0.035), whereas VEGF-A expression was not significantly related to overall survival (P=0.172). The factors significantly related to poor prognosis in univariate analysis were tumor size, portal vein invasion, microvascular thrombi, intrahepatic metastasis, tumor capsule invasion, liver capsule invasion, preoperative serum albumin level, and VEGF-A ratio. Multivariate analysis showed that a poor prognosis in HCC patients was significantly related to portal vein invasion (hazard ratio=3.381, P<0.001), intrahepatic metastasis (hazard ratio=2.379, P<0.001), tumor size (hazard ratio=1.834, P=0.003), and preoperative serum albumin level (hazard ratio=2.050, P=0.006). Conclusions: Our study showed that the expression of VEGF-A is positively correlated with the recurrence rate of HCC after curative resection. Therefore, a high expression of VEGF-A might be predictive of HCC recurrence after curative resection.

참고문헌 (23)

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간세포암종에 대한 간절제술 후 조기재발에 영향을 미치는 위험인자강구정, 김용훈, 박의준, 임태진대한간학회 · Clinical and Molecular Hepatology2008 · 제14권 제3호No Association of Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer김시내, 김종광, 문준호, 배한익, 손상균, 유완식, 이수정, 정호영, 채의수대한암학회 · Cancer Research and Treatment2009 · 제41권 제4호간 전이를 동반한 대장암에서의 VEGF-A, VEGFR-1, VEGFR-2 발현 양상과 미세혈관 밀도의 비교김영, 김현수, 민병우, 이경화, 이재혁, 정은희대한병리학회 · Journal of Pathology and Translational Medicine2010 · 제44권 제6호Predictors of Micrometastases in Patients with Barcelona Clinic Liver Cancer Classification B Hepatocellular Carcinoma서석원, 최유신연세대학교의과대학 · Yonsei Medical Journal2017 · 제58권 제4호Expression Characteristics of KAI1 and Vascular Endothelial Growth Factor and Their Diagnostic Value for Hepatocellular CarcinomaCheng-Guang Zhao, Hong-Yu Sun, Hua Chen, Wei-E Zheng, Wu Zhang거트앤리버 소화기연관학회협의회 · Gut and Liver2014 · 제8권 제5호The Combination of Periostin Overexpression and Microvascular Invasion Is Related to a Poor Prognosis for Hepatocellular CarcinomaGhil Suk Yoon, Hye Won Lee, Keun-Gyu Park, Keun Hur, Se Young Jang, Soo Young Park, Won Kee Lee, Won Young Tak, Yeon-Kyung Choi, Young Oh Kweon거트앤리버 소화기연관학회협의회 · Gut and Liver2016 · 제10권 제6호

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