Sigmoid colon metastasis from hepatocellular carcinoma
2
조회
0
다운로드
1
인용
0
참고문헌
초록
Hepatocellular carcinoma (HCC) is a major health problem worldwide, and it has a poor prognosis. Extrahepatic metastasis from HCC is not unusual, with direct invasion representing the main spreading mode. Sites that are frequently involved are the lung, bone, and lymph nodes. There are few reports of HCC invading the distant gastrointestinal tract, especially hematogenously. Herein we report a case of sigmoid colon metastasis from HCC. The patient was diagnosed with HCC and treated with transcatheter arterial chemoembolization (TACE). Eighteen months after TACE the patient presented with abdominal pain on the left lower quadrant, and a CT scan showed an enhanced mass on the sigmoid colon. Immunohistochemical staining revealed that a tumor cell was positive for polyclonal carcinoembryonic antigen and weakly positive for hepatocyte antigen, supporting the diagnosis of HCC metastasis. The patient underwent anterior resection for the metastatic HCC.
Abstract
Hepatocellular carcinoma (HCC) is a major health problem worldwide, and it has a poor prognosis. Extrahepatic metastasis from HCC is not unusual, with direct invasion representing the main spreading mode. Sites that are frequently involved are the lung, bone, and lymph nodes. There are few reports of HCC invading the distant gastrointestinal tract, especially hematogenously. Herein we report a case of sigmoid colon metastasis from HCC. The patient was diagnosed with HCC and treated with transcatheter arterial chemoembolization (TACE). Eighteen months after TACE the patient presented with abdominal pain on the left lower quadrant, and a CT scan showed an enhanced mass on the sigmoid colon. Immunohistochemical staining revealed that a tumor cell was positive for polyclonal carcinoembryonic antigen and weakly positive for hepatocyte antigen, supporting the diagnosis of HCC metastasis. The patient underwent anterior resection for the metastatic HCC.
참고문헌 (17)
- Bosch FX, "Primary liver cancer: worldwide incidence and trends", Gastroenterology, 127(1), pp.S5~S16 (2004)
- Llovet JM, "Hepatocellular carcinoma", Lancet, 362, pp.1907~1917 (2003)
- Bruix J, "Prognostic prediction and treatment strategy in hepatocellular carcinoma", Hepatology, 35, pp.519~524 (2002)
- Anthony PP, "Primary carcinoma of the liver: a study of 282 cases in Ugandan Africans", J Pathol, 110, pp.37~48 (1973)
- Nakashima T, "Pathology of hepatocellular carcinoma in Japan. 232 consecutive cases autopsied in ten years", Cancer, 51, pp.863~877 (1983)
- Lin CP, "Gastrointestinal metastasis in hepatocellular carcinoma: radiological and endoscopic studies of 11 cases", J Gastroenterol Hepatol, 15, pp.536~541 (2000)
- Chen LT, "Gastrointestinal tract involvement in hepatocellular carcinoma: clinical, radiological and endoscopic studies", Endoscopy, 22, pp.118~123 (1990)
- Nozaki Y, "Colonic metastasis from hepatocellular carcinoma: manifested by gastrointestinal bleeding", Dig Dis Sci, 53, pp.3265~3266 (2008)
- Park MS, "Radiologic findings of gastrointestinal tract involvement in hepatocellular carcinoma", J Comput Assist Tomogr, 26, pp.95~101 (2002)
- Yang PM, "Metastasis of hepatocellular carcinoma to the proximal jejunum manifested by occult gastrointestinal bleeding", Am J Gastroenterol, 82, pp.165~167 (1987)
- Sandler RS, "Endoscopic appearance of cancer metastatic to the stomach", J Clin Gastroenterol, 3(1), pp.35~37 (1981)
- Hurlimann J, "Immunohistochemistry in the differential diagnosis of liver carcinomas", Am J Surg Pathol, 15, pp.280~288 (1991)
- Koelma IA, "Hepatocellular carcinoma, adenoma, and focal nodular hyperplasia. Comparative histopathologic study with immunohistochemical parameters", Arch Pathol Lab Med, 110, pp.1035~1040 (1986)
- Kojiro M, "Distribution of albuminand", or alpha-fetoprotein-positive cells in hepatocellular carcinoma, 1981, pp.44, 221~226
- Natsuizaka M, "Clinical features of hepatocellular carcinoma with extrahepatic metastases", J Gastroenterol Hepatol, 20, pp.1781~1787 (2005)
- Uka K, "Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma", World J Gastroenterol, 13, pp.414~420 (2007)
- Park JS, "What is the best treatment modality for adrenal metastasis from hepatocellular carcinoma?", J Surg Oncol, 96, pp.32~36 (2007)