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Management of hepatitis C viral infection in chronic kidney disease patients on hemodialysis in the era of direct-acting antivirals

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초록

The advent of novel, direct-acting antiviral (DAA) regimens for hepatitis C virus (HCV) infection has revolutionized its treatment by producing a sustained virologic response of more than 95% with few side effects and no comorbidities in the general population. Until recently, ideal DAA regimens have not been available to patients with severe renal impairment and end-stage renal disease because there are limited data on the pharmacokinetics, safety, and efficacy of treatment in this unique population. In a hemodialysis context, identifying patients in need of treatment and preventing HCV transmission may also be a matter of concern. Recently published studies suggest that a combination of paritaprevir/ ritonavir/ombitasvir and dasabuvir, elbasvir/grazoprevir, or glecaprevir/pibrentasvir successfully treats HCV infection in chronic kidney disease stage 4 or 5 patients with or without hemodialysis.

Abstract

The advent of novel, direct-acting antiviral (DAA) regimens for hepatitis C virus (HCV) infection has revolutionized its treatment by producing a sustained virologic response of more than 95% with few side effects and no comorbidities in the general population. Until recently, ideal DAA regimens have not been available to patients with severe renal impairment and end-stage renal disease because there are limited data on the pharmacokinetics, safety, and efficacy of treatment in this unique population. In a hemodialysis context, identifying patients in need of treatment and preventing HCV transmission may also be a matter of concern. Recently published studies suggest that a combination of paritaprevir/ ritonavir/ombitasvir and dasabuvir, elbasvir/grazoprevir, or glecaprevir/pibrentasvir successfully treats HCV infection in chronic kidney disease stage 4 or 5 patients with or without hemodialysis.

참고문헌 (43)

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관련 논문AI추천

Hepatitis C virus infection in chronic kidney disease: paradigm shift in managementIl Han Song, So Mi Kim대한내과학회 · The Korean Journal of Internal Medicine2018 · 제33권 제4호Safety and effectiveness of direct-acting antivirals in patients with chronic hepatitis C and chronic kidney disease배시현, 성필수, 양진모, 윤승규, 최종영, Chang Wook Kim, Do Seon Song, Hae Lim Lee, Hee Chul Nam, Hee Yeon Kim, Hyun Yang, Jeong Won Jang, Ji Eun Ryu, Jung Hyun Kwon, Myeong Jun Song, Seok-Hwan Kim, Soon Kyu Lee, Soon Woo Nam, Sung Won Lee, Sun Hong Yoo, U Im Chang대한내과학회 · The Korean Journal of Internal Medicine2022 · 제37권 제5호Full-dose sofosbuvir plus low-dose ribavirin for hepatitis C virus genotype 2-infected patients on hemodialysisHee Yeon Seo, Jong Wook Choi, Myeong-Sook Seo, Soon Young Ko, Sun-Young Yoon대한내과학회 · The Korean Journal of Internal Medicine2020 · 제35권 제3호Efficacy and Safety of Daclatasvir and Asunaprevir in Patients with Hepatitis C Virus Genotype 1b Infection on HemodialysisByung Seok Lee, Do Seon Song, Hong Soo Kim, Ji Hoon Kim, Ji Woong Jang, Jung Hyun Kwon, Myeong Jun Song, Sae Hwan Lee, Seok Bae Kim, Seok Hyun Kim, Soon Young Ko, Tae Hee Lee거트앤리버 소화기연관학회협의회 · Gut and Liver2019 · 제13권 제2호Comedications and potential drug-drug interactions with direct-acting antivirals in hepatitis C patients on hemodialysisCheng-Ting Hsu, Chia-Yen Dai, Ching-I Huang, Chung-Feng Huang, Jee-Fu Huang, Jer-Ming Chang, Jia-Jung Lee, Jiun-Chi Huang, Meng-Hsuan Hsieh, Ming-Lung Yu, Ming-Lun Yeh, Ming-Yen Hsieh, Po-Cheng Liang, Po-Yao Hsu, Shang-Jyh Hwang, Sheng-Wen Niu, Shinn-Cherng Chen, Szu-Chia Chen, Tyng-Yuan Jang, Wan-Long Chuang, Yi-Hung Lin, Yi-Wen Chiu, Yu-Ju Wei, Zu-Yau Lin대한간학회 · Clinical and Molecular Hepatology2021 · 제27권 제1호Use of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus infection and severe renal impairmentChen-Hua Liu, Chien-Hung Chen, Ching-Sheng Hsu, Desmond Y. H. Yap, Grace L. H. Wong, Kevin S. H. Liu, Man-Fung Yuen, Michael K. K. Li, Ming-Chang Tsai, Ming-Lung Yu, Yee-Man Kan, Yee Tak Hui, Yu-Chun Hsu대한간학회 · Clinical and Molecular Hepatology2020 · 제26권 제4호

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