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Effects of different exercise modalities on novel hepatic steatosis indices in overweight women with type 2 diabetes

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Background/Aims: Fatty liver is a clinical and pathologic condition in individuals with type 2 diabetes (T2D). The purpose of this study is to examine the effects of different exercise modalities on non-alcoholic fatty liver indices (fatty liver index [FLI], lipid accumulation product [LAP], hepatic steatosis index [HSI], and Framingham Steatosis Index [FSI]) in women with T2D. Methods: Fifty-two women with T2D and a mean age of 55.07±5.92 yrs, body mass index (BMI) 28.94±4.09 kg/m2, and hemoglobin A1c (HbA1c) 9.41±0.82% were randomized to a sprint interval training (SIT) (n=17), combined aerobic and resistance (A+R) training (n=17), or control group (n=18) for 10 weeks. Two-way repeated analysis of variance (ANOVA) was used to find differences between groups and the effects of time and Time×Group interactions after 10 weeks on non-alcoholic fatty liver indices. After this, ANOVA models were constructed to determine the effects of group allocation and change in non-alcoholic fatty liver indices. Results: There were significant time interactions for FLI (P<0.001), HSI (P<0.001), and LAP (P<0.001). Also, there were significant Time×Group interactions for fasting blood glucose (P=0.034), and HbA1c (P=0.006). Conclusions: Results highlight that exercise training, independent of mode of training, is an effective strategy to improve some indices related to hepatic steatosis and blood glucose profiles in women with T2D.

Abstract

Background/Aims: Fatty liver is a clinical and pathologic condition in individuals with type 2 diabetes (T2D). The purpose of this study is to examine the effects of different exercise modalities on non-alcoholic fatty liver indices (fatty liver index [FLI], lipid accumulation product [LAP], hepatic steatosis index [HSI], and Framingham Steatosis Index [FSI]) in women with T2D. Methods: Fifty-two women with T2D and a mean age of 55.07±5.92 yrs, body mass index (BMI) 28.94±4.09 kg/m2, and hemoglobin A1c (HbA1c) 9.41±0.82% were randomized to a sprint interval training (SIT) (n=17), combined aerobic and resistance (A+R) training (n=17), or control group (n=18) for 10 weeks. Two-way repeated analysis of variance (ANOVA) was used to find differences between groups and the effects of time and Time×Group interactions after 10 weeks on non-alcoholic fatty liver indices. After this, ANOVA models were constructed to determine the effects of group allocation and change in non-alcoholic fatty liver indices. Results: There were significant time interactions for FLI (P<0.001), HSI (P<0.001), and LAP (P<0.001). Also, there were significant Time×Group interactions for fasting blood glucose (P=0.034), and HbA1c (P=0.006). Conclusions: Results highlight that exercise training, independent of mode of training, is an effective strategy to improve some indices related to hepatic steatosis and blood glucose profiles in women with T2D.

참고문헌 (47)

  1. Lara-Castro C, "Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome", Endocrinol Metab Clin North Am, 37, pp.841~856 (2008)
  2. Firneisz G, "Non-alcoholic fatty liver disease and type 2 diabetes mellitus : the liver disease of our age", World J Gastroenterol, 20, pp.9072~9089 (2014)
  3. Saponaro C, "Nonalcoholic fatty liver disease and type 2 diabetes : common pathophysiologic mechanisms", Curr Diab Rep, 15, pp.607~ (2015)
  4. Garcia-Compean D, "Liver cirrhosis and diabetes : risk factors, pathophysiology, clinical implications and management", World J Gastroenterol, 15, pp.280~288 (2009)
  5. Fitzpatrick E, "Noninvasive biomarkers in non-alcoholic fatty liver disease : current status and a glimpse of the future", World J Gastroenterol, 20, pp.10851~10863 (2014)
  6. Koot BG, "Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children", Obesity(Silver Spring), 21, pp.583~590 (2013)
  7. Kahl S, "Comparison of liver fat indices for the diagnosis of hepatic steatosis and insulin resistance", PLoS One, 9, pp.e94059~ (2014)
  8. Lee JH, "Hepatic steatosis index : a simple screening tool reflecting nonalcoholic fatty liver disease", Dig Liver Dis, 42, pp.503~508 (2010)
  9. Sviklāne L, "Fatty liver index and hepatic steatosis index for prediction of non‐alcoholic fatty liver disease in type 1 diabetes", J Gastroenterol Hepatol, 33, pp.270~276 (2018)
  10. Cheung CL, "Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA", BMC Med, 12, pp.154~ (2014)
  11. Long MT, "Development and validation of the Framingham steatosis index to identify persons with hepatic steatosis", Clin Gastroenterol Hepatol, 14, pp.1172~1180 (2016)[DOI]
  12. Bhatt HB, "Fatty liver disease in diabetes mellitus", Hepatobiliary Surg Nutr, 4, pp.101~108 (2015)
  13. Warburton DE, "Health benefits of physical activity : the evidence", CMAJ, 174, pp.801~809 (2006)
  14. Zhou K, "The fatty liver index(FLI)and incident hypertension : a longitudinal study among Chinese population", Lipids Health Dis, 17, pp.214~ (2018)
  15. Balducci S, "Effect of high-versus low-intensity supervised aerobic and resistance training on modifiable cardiovascular risk factors in type 2diabetes; the Italian Diabetes and Exercise Study(IDES)", PLoS One, 7, pp.e49297~ (2012)
  16. Paluch AE, "Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus", Current Cardiovascular Risk Reports, 5, pp.481~ (2011)
  17. Bacchi E, "Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease(the RAED2 Randomized Trial)", Hepatology, 58, pp.1287~1295 (2013)
  18. Pandis N, "CONSORT 2010 statement: extension checklist for reporting within person randomised trials", BMJ, 357, pp.j2835~ (2017)
  19. Bacchi E, "Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects : a randomized controlled trial(the RAED2study)", Diabetes Care, 35, pp.676~682 (2012)
  20. Albright A, "American College of Sports Medicine position stand. Exercise and type 2 diabetes", Med Sci Sports Exerc, 32, pp.1345~1360 (2000)
  21. Larose J, "Comparison of strength development with resistance training and combined exercise training in type 2 diabetes", Scand J Med Sci Sports, 22, pp.e45~ (2012)[DOI]
  22. Higgins TP, "Heterogeneous responses of personalised high intensity interval training on type 2 diabetes mellitus and cardiovascular disease risk in young healthy adults", Clin Hemorheol Microcirc, 59, pp.365~377 (2015)
  23. Ball SD, "Comparison of anthropometry to DXA : a new prediction equation for men", Eur J Clin Nutr, 58, pp.1525~1531 (2004)
  24. Han TS, "Associations of body composition with type 2 diabetes mellitus", Diabet Med, 15, pp.129~135 (1998)
  25. Ahmadizad S, "Effects of resistance versus endurance training on serum adiponectin and insulin resistance index", Eur J Endocrinol, 157, pp.625~631 (2007)
  26. Leutner M, "The fatty liver index(FLI)relates to diabetes-specific parameters and an adverse lipid profile in a cohort of nondiabetic, dyslipidemic patients", J Am Coll Nutr, 36, pp.287~294 (2017)
  27. Mazidi M, "Lipid accumulation product and triglycerides", glucose index are useful predictors of insulin resistance, 2018, pp.32, 266~270
  28. Pineda H, "Lipid accumulation product(LAP)and visceral adiposity index(VAI)a simple and clinically useful surrogate marker for metabolic syndrome and cardiovascular disease predictor in non-diabetic Venezuelan adults", J Pharm Pharm Scien, 2, pp.1~8 (2017)
  29. Shen YN, "External validation of non-invasive prediction models for identifying ultrasonography-diagnosed fatty liver disease in a Chinese population", Medicine (Baltimore), 96, pp.e7610~ (2017)
  30. Sambataro M, "Lipid accumulation in overweight type 2 diabetic subjects : relationships with insulin sensitivity and adipokines", Acta Diabetol, 50, pp.301~307 (2013)
  31. Hallsworth K, "Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease:a randomized controlled trial", Clin Sci(Lond), 129, pp.1097~1105 (2015)
  32. Balducci S, "Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study(IDES)", Diabetes Res Clin Pract, 109, pp.355~363 (2015)
  33. Kotronen A, "Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes", Gastroenterology, 135, pp.122~130 (2008)
  34. Gastaldelli A, "Relationship between hepatic", visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects, 2007, pp.133, 496~506
  35. Rector RS, "Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats", Am J Physiol Gastrointest Liver Physiol, 294, pp.G619~ (2008)[DOI]
  36. Perseghin G, "Habitual physical activity is associated with intrahepatic fat content in humans", Diabetes Care, 30, pp.683~688 (2007)
  37. Church TS, "Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease", Gastroenterology, 130, pp.2023~2030 (2006)
  38. Oh S, "High-intensity aerobic exercise improves both hepatic fat content and stiffness in sedentary obese men with nonalcoholic fatty liver disease", Sci Rep, 7, pp.43029~ (2017)
  39. Barsalani R, "Effect of exercise training and isoflavones on hepatic steatosis in overweight postmenopausal women", Climacteric, 16, pp.88~95 (2013)
  40. Johnson NA, "Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss", Hepatology, 50, pp.1105~1112 (2009)
  41. Sigal RJ, "The roles of catecholamines in glucoregulation in intense exercise as defined by the islet cell clamp technique", Diabetes, 45, pp.148~156 (1996)
  42. Cassidy S, "High intensity intermittent exercise improves cardiac structure and function and reduces liver fat in patients with type 2diabetes : a randomised controlled trial", Diabetologia, 59, pp.56~66 (2016)
  43. Toohey K, "High-intensity interval training versus continuous moderate intensity training : effects on health outcomes and cardiometabolic disease risk factors in cancer survivors : a pilot study", J Sci Med Sport, 19, pp.e94~ (2015)
  44. Trovato FM, "Mediterranean diet and non-alcoholic fatty liver disease : the need of extended and comprehensive interventions", Clin Nutr, 34, pp.86~88 (2015)
  45. Whyte LJ, "Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight", obese men, 2010, pp.59, 1421~1428
  46. Hamed NS, "Effect of high intensity interval training on diabetic obese women with polyneuropathy : a randomized controlled clinical trial", Physical Therapy and Rehabilitation, 1, pp.4~ (2014)
  47. Francois ME, "Effectiveness and safety of high-intensity interval training in patients with type 2 diabetes", Diabetes Spectr, 28, pp.39~44 (2015)

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