Long non-coding RNAs in liver diseases: Focusing on nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease
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초록
Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.
Abstract
Long non-coding RNAs (lncRNAs), a class of transcribed RNA molecules with the lengths exceeding 200 nucleotides, are not translated into protein. They can modulate protein-coding genes by controlling transcriptional and posttranscriptional processes. The dysregulation of lncRNAs has been related to various pathological disorders. In this review, we summarized the current knowledge of lncRNAs and their implications in the pathogenesis of three common liver diseases: nonalcoholic fatty liver disease, alcohol-related liver disease, and cholestatic liver disease. Future studies to further define the role of lncRNAs and their mechanisms in various types of liver diseases should be explored. An improved understanding from these studies will provide us a useful perspective leading to mechanism-based intervention by targeting specific lncRNAs for the treatment of liver diseases.
참고문헌 (66)
- ENCODE Project Consortium, "Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project", Nature, 447, pp.799~816 (2007)
- ENCODE Project Consortium, "An integrated encyclopedia of DNA elements in the human genome", Nature, 489, pp.57~74 (2012)
- Yamamura S, "Interaction and cross-talk between non-coding RNAs", Cell Mol Life Sci, 75, pp.467~484 (2018)
- Djebali S, "Landscape of transcription in human cells", Nature, 489, pp.101~108 (2012)
- Erdmann VA, "Collection of mRNA-like non-coding RNAs", Nucleic Acids Res, 27, pp.192~195 (1999)
- Danko CG, "Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells", Mol Cell, 50, pp.212~222 (2013)
- Johnsson P, "Evolutionary conservation of long non-coding RNAs; sequence, structure, function", Biochim Biophys Acta, 1840, pp.1063~1071 (2014)
- Novikova IV, "Tackling structures of long noncoding RNAs", Int J Mol Sci, 14, pp.23672~23684 (2013)
- Yan K, "Structure prediction : new insights into decrypting long noncoding RNAs", Int J Mol Sci, 17, pp.132~ (2016)
- Jasdeep Kaur Dhanoa, "Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review", 한국축산학회지, 60(10), pp.1~10 (2018), 한국축산학회[DOI]
- Hermans-Beijnsberger S, "Long non-coding RNAs in the failing heart and vasculature", Noncoding RNA Res, 3, pp.118~130 (2018)
- Jarroux J, "History, Discovery, and Classification of lncRNAs", Adv Exp Med Biol, 1008, pp.1~46 (2017)
- Huang B, "Regulatory non-coding RNAs : revolutionizing the RNA world", Mol Biol Rep, 41, pp.3915~3923 (2014)
- Dykes IM, "Transcriptional and post-transcriptional gene regulation by long non-coding RNA", Genomics Proteomics Bioinformatics, 15, pp.177~186 (2017)
- Wang KC, "Molecular mechanisms of long noncoding RNAs", Mol Cell, 43, pp.904~914 (2011)
- Guttman M, "lincRNAs act in the circuitry controlling pluripotency and differentiation", Nature, 477, pp.295~300 (2011)
- Tsai MC, "Long noncoding RNA as modular scaffold of histone modification complexes", Science, 329, pp.689~693 (2010)
- Long Y, "How do lncRNAs regulate transcription?", Sci Adv, 3, pp.eaao2110~ (2017)
- Keniry A, "The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r", Nat Cell Biol, 14, pp.659~665 (2012)
- Yoon JH, "Functional interactions among microRNAs and long noncoding RNAs", Semin Cell Dev Biol, 34, pp.9~14 (2014)
- Salmena L, "A ceRNA hypothesis : the Rosetta Stone of a hidden RNA language?", Cell, 146, pp.353~358 (2011)
- Ebert MS, "MicroRNA sponges : progress and possibilities", RNA, 16, pp.2043~2050 (2010)
- Streba LA, "Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma : an open question", World J Gastroenterol, 21, pp.4103~4110 (2015)
- Zhao Y, "Long non-coding RNA in liver metabolism and disease : current status", Liver Res, 1, pp.163~167 (2017)
- Chen G, "LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase(ATGL)", Sci Rep, 6, pp.35531~ (2016)
- Puigserver P, "Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction", Nature, 423, pp.550~555 (2003)
- Zhu X, "Upregulation of lncRNA MEG3promotes hepatic insulin resistance via increasing FoxO1 expression", Biochem Biophys Res Commun, 469, pp.319~325 (2016)
- Zhu X, "lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression", Int J Mol Med, 43, pp.345~357 (2019)
- Zhang M, "Long noncoding RNA lncARSR promotes hepatic lipogenesis via Akt", SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis, 2018, pp.499, 66~70
- Huang J, "Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating Akt", SREBP-2, Life Sci, pp.2018, 203[DOI]
- Atanasovska B, "A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis", Hepatology, 66, pp.794~808 (2017)
- Wang J, "Long noncoding RNA lncSHGL recruits hnRNPA1 to suppress hepatic gluconeogenesis and lipogenesis", Diabetes, 67, pp.581~593 (2018)
- Qian K, "The long noncoding RNA NEAT1 interacted with miR-101 modulates breast cancer growth by targeting EZH2", Arch Biochem Biophys, 615, pp.1~9 (2017)
- Wang X, "Down-regulation of lncRNA-NEAT1 alleviated the nonalcoholic fatty liver disease via mTOR", S6K1 signaling pathway, 2018, pp.119, 1567~1574
- Yan B, "Aberrant expression of long noncoding RNAs in early diabetic retinopathy", Invest Ophthalmol Vis Sci, 55, pp.941~951 (2014)
- Puthanveetil P, "Long noncoding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells", J Cell Mol Med, 19, pp.1418~1425 (2015)
- Yan C, "Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability", Sci Rep, 6, pp.22640~ (2016)
- Leti F, "Altered expression of MALAT1 lncRNA in nonalcoholic steatohepatitis fibrosis regulates CXCL5 in hepatic stellate cells", Transl Res, 190, pp.25~39.e21 (2017)
- Liu J, "LncRNA-H19 promotes hepatic lipogenesis by directly regulating miR-130a", PPARγ axis in non-alcoholic fatty liver disease, 2019, pp.39, BSR20181722~
- Wang H, "Long non-coding RNA(lncRNA)H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes", J Cell Mol Med, 24, pp.1399~1412 (2020)
- Liu C, "Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis", Hepatology, 67, pp.1768~1783 (2018)
- Rehm J, "Global burden of alcoholic liver diseases", J Hepatol, 59, pp.160~168 (2013)
- Liangpunsakul S, "Alcoholic liver disease in Asia, Europe, and North America", Gastroenterology, 150, pp.1786~1797 (2016)
- Wang Q, "The long non-coding RNA MEG3", miR-let-7c-5p axis regulates ethanol-induced hepatic steatosis and apoptosis by targeting NLRC5, 2018, pp.9, 302~
- Quinn JJ, "Unique features of long non-coding RNA biogenesis and function", Nat Rev Genet, 17, pp.47~62 (2016)
- Yang Z, "LncRNA AK054921 and AK128652 are potential serum biomarkers and predictors of patient survival with alcoholic cirrhosis", Hepatol Commun, 1, pp.513~523 (2017)
- Lee YS, "Retinoic acids and hepatic stellate cells in liver disease", J Gastroenterol Hepatol, 27(Suppl 2), pp.75~79 (2012)
- Tsuchida T, "Mechanisms of hepatic stellate cell activation", Nat Rev Gastroenterol Hepatol, 14, pp.397~411 (2017)
- He Z, "The roles and mechanisms of lncRNAs in liver fibrosis", Int J Mol Sci, 21, pp.1482~ (2020)
- Zhang L, "Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay", Hepatology, 65, pp.604~615 (2017)
- Yu F, "MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis", Cell Cycle, 14, pp.3885~3896 (2015)
- Jiang X, "The mechanism of lncRNA H19 in fibrosis and its potential as novel therapeutic target", Mech Ageing Dev, 188, pp.111243~ (2020)
- Zhou B, "LncRNA Gm5091 alleviates alcoholic hepatic fibrosis by sponging miR-27b", 23b, Cell Biol Int, pp.2018, 42[DOI]
- Goldstein J, "Novel and emerging therapies for cholestatic liver diseases", Liver Int, 38, pp.1520~1535 (2018)
- Chiang JY, "Recent advances in understanding bile acid homeostasis", F1000Res, 6, pp.2029~ (2017)
- Goodwin B, "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis", Mol Cell, 6, pp.517~526 (2000)
- Zhang Y, "Role of nuclear receptor SHP in metabolism and cancer", Biochim Biophys Acta, 1812, pp.893~908 (2011)
- Denson LA, "The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp", Gastroenterology, 121, pp.140~147 (2001)
- Zhang L, "H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis", Cell Death Dis, 10, pp.168~ (2019)
- Gregory PA, "The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1", Nat Cell Biol, 10, pp.593~601 (2008)
- Song Y, "H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule", Hepatology, 66, pp.1183~1196 (2017)
- Li X, "The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice", Hepatology, 66, pp.869~884 (2017)
- Xiao Y, "Long Noncoding RNA H19 contributes to cholangiocyte proliferation and cholestatic liver fibrosis in biliary atresia", Hepatology, 70, pp.1658~1673 (2019)
- Nagahashi M, "Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression", Hepatology, 61, pp.1216~1226 (2015)
- Liu R, "Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2", Hepatology, 60, pp.908~918 (2014)
- Li X, "Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions", Cells, 9, pp.190~ (2020)
