The effect of moderate alcohol drinking in nonalcoholic fatty liver disease
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초록
Nonalcoholic fatty liver disease (NAFLD) is defined by fat accumulation in liver that is not caused by excessive alcohol consumption. Safe limits of alcohol consumption in NAFLD are usually defined as alcohol consumption of less than 210 g per week for men and 140 g per week for women (30 g/day in men, 20 g/day in women) and alcohol consumption below safe limits is generally regarded as moderate alcohol consumption. Many studies have investigated the effects of moderate alcohol consumption on NAFLD patients. Some studies showed that moderate alcohol consumption prevented the progression of fibrosis in the liver, whereas other reports showed worsening of fibrosis in the liver based on serologic, radiologic and liver biopsy findings compared with effects on total abstainers. NAFLD is also thought to be a hepatic manifestation of metabolic syndrome, and when combined with excessive alcohol consumption results in the development of components of metabolic syndrome and systemic harmful effects. The effects of moderate alcohol consumption on NAFLD have yet to be established.
Abstract
Nonalcoholic fatty liver disease (NAFLD) is defined by fat accumulation in liver that is not caused by excessive alcohol consumption. Safe limits of alcohol consumption in NAFLD are usually defined as alcohol consumption of less than 210 g per week for men and 140 g per week for women (30 g/day in men, 20 g/day in women) and alcohol consumption below safe limits is generally regarded as moderate alcohol consumption. Many studies have investigated the effects of moderate alcohol consumption on NAFLD patients. Some studies showed that moderate alcohol consumption prevented the progression of fibrosis in the liver, whereas other reports showed worsening of fibrosis in the liver based on serologic, radiologic and liver biopsy findings compared with effects on total abstainers. NAFLD is also thought to be a hepatic manifestation of metabolic syndrome, and when combined with excessive alcohol consumption results in the development of components of metabolic syndrome and systemic harmful effects. The effects of moderate alcohol consumption on NAFLD have yet to be established.
참고문헌 (42)
- Metrakos P, "Non-alcoholic fatty liver disease--a chronic disease of the 21st century", J Biomed Res, 32, pp.327~335 (2018)
- Ntandja Wandji LC, "Combined alcoholic and non-alcoholic steatohepatitis", JHEP Rep, 2, pp.100101~ (2020)
- Inbeom Kwon, "Effects of Moderate Alcohol Drinking in Patients with Nonalcoholic Fatty Liver Disease", Gut and Liver, 13(3), pp.308~314 (2019), 거트앤리버 소화기연관학회협의회[DOI]
- Weng G, "Effect of alcohol consumption on nonalcoholic fatty liver disease", Transl Gastroenterol Hepatol, 4, pp.70~ (2019)
- Åberg F, "Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population", Hepatology, 67, pp.2141~2149 (2018)
- Dixon JB, "Nonalcoholic fatty liver disease : predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese", Gastroenterology, 121, pp.91~100 (2001)
- Suzuki A, "Light to moderate alcohol consumption is associated with lower frequency of hypertransaminasemia", Am J Gastroenterol, 102, pp.1912~1919 (2007)
- Gunji T, "Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population", Am J Gastroenterol, 104, pp.2189~2195 (2009)
- Yamada T, "Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup", J Gastroenterol Hepatol, 25, pp.352~356 (2010)
- Hiramine Y, "Alcohol drinking patterns and the risk of fatty liver in Japanese men", J Gastroenterol, 46, pp.519~528 (2011)
- Gunji T, "Modest alcohol consumption has an inverse association with liver fat content", Hepatogastroenterology, 59, pp.2552~2556 (2012)
- Moriya A, "Alcohol consumption appears to protect against nonalcoholic fatty liver disease", Aliment Pharmacol Ther, 33, pp.378~388 (2011)
- Moriya A, "Roles of alcohol consumption in fatty liver : a longitudinal study", J Hepatol, 62, pp.921~927 (2015)
- Sookoian S, "Modest alcohol consumption decreases the risk of non-alcoholic fatty liver disease : a meta-analysis of 43 175 individuals", Gut, 63, pp.530~532 (2014)
- Dunn W, "Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with nonalcoholic fatty liver disease(NAFLD)", J Hepatol, 57, pp.384~391 (2012)
- Buzzetti E, "The multiple-hit pathogenesis of non-alcoholic fatty liver disease(NAFLD)", Metabolism, 65, pp.1038~1048 (2016)
- Kanuri G, "Moderate alcohol consumption diminishes the development of non‑alcoholic fatty liver disease(NAFLD)in ob", ob mice, 2016, pp.55, 1153~1164
- Courtney KE, "Binge drinking in young adults : data, definitions, and determinants", Psychol Bull, 135, pp.142~156 (2009)
- "Drinking levels defined"[URL]
- Mitchell T, "Type and pattern of alcohol consumption is associated with liver fibrosis in patients with non-alcoholic fatty liver disease", Am J Gastroenterol, 113, pp.1484~1493 (2018)
- Hézode C, "Impact of moderate alcohol consumption on histological activity and fibrosis in patients with chronic hepatitis C, and specific influence of steatosis : a prospective study", Aliment Pharmacol Ther, 17, pp.1031~1037 (2003)
- Ekstedt M, "Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease", Scand J Gastroenterol, 44, pp.366~374 (2009)
- Bellentani S, "Prevalence of and risk factors for hepatic steatosis in Northern Italy", Ann Intern Med, 132, pp.112~117 (2000)
- Ascha MS, "The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis", Hepatology, 51, pp.1972~1978 (2010)
- Yi SW, "Risk factors for hepatocellular carcinoma by age, sex, and liver disorder status : a prospective cohort study in Korea", Cancer, 124, pp.2748~2757 (2018)
- Becker U, "Prediction of risk of liver disease by alcohol intake, sex, and age : a prospective population study", Hepatology, 23, pp.1025~1029 (1996)
- Bellentani S, "Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group", Gut, 41, pp.845~850 (1997)
- Bellentani S, "Clinical course and risk factors of hepatitis C virus related liver disease in the general population : report from the Dionysos study", Gut, 44, pp.874~880 (1999)
- Hart CL, "Effect of body mass index and alcohol consumption on liver disease:analysis of data from two prospective cohort studies", BMJ, 340, pp.c1240~ (2010)
- Armstrong GL, "The prevalence of hepatitis C virus infection in the United States, 1999 through 2002", Ann Intern Med, 144, pp.705~714 (2006)
- Chang Y, "Nonheavy drinking and worsening of noninvasive fibrosis markers in nonalcoholic fatty liver disease : a cohort study", Hepatology, 69, pp.64~75 (2019)
- Ekstedt M, "Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up", Hepatology, 61, pp.1547~1554 (2015)
- Targher G, "Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men : role of visceral fat accumulation", Diabetes Care, 27, pp.2498~2500 (2004)
- Lee YJ, "The relationship between arterial stiffness and nonalcoholic fatty liver disease", Dig Dis Sci, 57, pp.196~203 (2012)
- Oni ET, "A systematic review : burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care?", Atherosclerosis, 230, pp.258~267 (2013)
- Sinn DH, "Modest alcohol consumption and carotid plaques or carotid artery stenosis in men with non-alcoholic fatty liver disease", Atherosclerosis, 234, pp.270~275 (2014)
- Åberg F, "Risks of light and moderate alcohol use in fatty liver disease : follow-up of population cohorts", Hepatology, 71, pp.835~848 (2020)
- 최윤정, "Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies", Cancer Research and Treatment, 50(2), pp.474~487 (2018), 대한암학회
- Bagnardi V, "Light alcohol drinking and cancer : a meta-analysis", Ann Oncol, 24, pp.301~308 (2013)
- Hamaguchi M, "Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome", World J Gastroenterol, 18, pp.1508~1516 (2012)
- Wong GL, "Association between anthropometric parameters and measurements of liver stiffness by transient elastography", Clin Gastroenterol Hepatol, 11, pp.295~302.e1-e3 (2013)
- Cotrim HP, "Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients", Eur J Gastroenterol Hepatol, 21, pp.969~972 (2009)