Alcoholic fatty liver disease elevates estimated coronary heart disease risk to levels comparable with those of nonalcoholic fatty liver disease in the Korean population: a cross-sectional study
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Background/Aims: A close relationship has been established between nonalcoholic fatty liver disease (NAFLD) andan elevated risk of coronary heart disease (CHD), but little is known about the association between alcoholic fatty liverdisease (AFLD) and CHD risk. The aim of this study was to determine whether AFLD is associated with elevated CHDrisk. Methods: We retrospectively enrolled 10,710 subjects out of 11,469 individuals who visited the Konkuk UniversityHealth Care Center for a routine health checkup in 2010. AFLD was diagnosed made when the usual amount of alcoholconsumption exceeded 210 g/week in males and 140 g/week in females for the previous 2 years and when hepaticsteatosis was detected by liver ultrasonography. The 10-year risk for CHD was estimated using the Framingham RiskScore. Results: Hepatic steatosis was diagnosed in 4,142 of the 10,710 individuals (38.7%); the remainder (i.e., n=6,568)became the control group. The 4,142 individuals with hepatic steatosis were divided into two groups: NAFLD (n=2,953)and AFLD (n=1,189). The risk of CHD was higher in AFLD (6.72±0.12) than in the control group (5.50±0.04, P<0.001),and comparable to that in NAFLD (7.32±0.07, P=0.02). Conclusions: Individuals with AFLD have an elevated 10-year risk of CHD that is comparable to those with NAFLD. Therefore, AFLD should be considered a significant risk for future CHD, and preventive measures should be considered earlier.
Abstract
Background/Aims: A close relationship has been established between nonalcoholic fatty liver disease (NAFLD) andan elevated risk of coronary heart disease (CHD), but little is known about the association between alcoholic fatty liverdisease (AFLD) and CHD risk. The aim of this study was to determine whether AFLD is associated with elevated CHDrisk. Methods: We retrospectively enrolled 10,710 subjects out of 11,469 individuals who visited the Konkuk UniversityHealth Care Center for a routine health checkup in 2010. AFLD was diagnosed made when the usual amount of alcoholconsumption exceeded 210 g/week in males and 140 g/week in females for the previous 2 years and when hepaticsteatosis was detected by liver ultrasonography. The 10-year risk for CHD was estimated using the Framingham RiskScore. Results: Hepatic steatosis was diagnosed in 4,142 of the 10,710 individuals (38.7%); the remainder (i.e., n=6,568)became the control group. The 4,142 individuals with hepatic steatosis were divided into two groups: NAFLD (n=2,953)and AFLD (n=1,189). The risk of CHD was higher in AFLD (6.72±0.12) than in the control group (5.50±0.04, P<0.001),and comparable to that in NAFLD (7.32±0.07, P=0.02). Conclusions: Individuals with AFLD have an elevated 10-year risk of CHD that is comparable to those with NAFLD. Therefore, AFLD should be considered a significant risk for future CHD, and preventive measures should be considered earlier.
참고문헌 (32)
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