Geographic difference of epidemiological features of HCV infection in Korea
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection.
Abstract
Background/Aims: The prevalence of hepatitis C virus (HCV) infection in Korea exhibits significant geographic variation, with it being higher in Busan and Jeonam than in other areas. The reason for this intranational geographic difference was investigated in this study by conducting a comparative analysis of the risk factors related to HCV infection among three geographic areas: the capital (Seoul), Busan, and the province of Jeolla. Methods: In total, 990 patients with chronic HCV infection were prospectively enrolled at 5 university hospitals located in Seoul (n=374), Busan (n=264), and Jeolla (n=352). A standardized questionnaire survey on the risk factors for HCV infection was administered to these three groups of patients, and a comparative analysis of the findings was performed. Results: The analysis revealed significant regional differences in exposure to the risk factors of HCV infection. By comparison with patients in Seoul as a control group in the multivariate analysis, patients in Busan had significantly more experience of invasive medical procedures, acupuncture, cosmetic procedures, and multiple sex partners. In contrast, patients in Jeolla were significantly older, and they had a higher prevalence of hepatocellular carcinoma, a lower prevalence of multiple sex partners, and had experienced fewer invasive procedures. Conclusions: There was a significant geographic difference in the exposure to potential risk factors of HCV infection between patients from the three studied regions. This may explain the regional variation of the prevalence of HCV infection in Korea, and should be taken into account when planning strategies for the prevention and management of HCV infection.
참고문헌 (13)
- Mohd Hanafiah K, "Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence", Hepatology, 57, pp.1333~1342 (2013)
- Armstrong GL, "The prevalence of hepatitis C virus infection in the United States, 1999 through 2002", Ann Intern Med, 144, pp.705~714 (2006)
- Frank C, "The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt", Lancet, 355, pp.887~891 (2000)
- Chowdhury A, "Hepatitis C virus infection in the general population: a community-based study in West Bengal, India", Hepatology, 37, pp.802~809 (2003)
- Seong MH, "Clinical and epidemiological features of hepatitis C virus infection in South Korea: a prospective, multicenter cohort study", J Med Virol, 85, pp.1724~1733 (2013)
- 김종엽, "Behavioral and Healthcare-Associated Risk Factors for Chronic Hepatitis C Virus Infection in Korea", Journal of Korean Medical Science, 27(11), pp.1371~1377 (2012), 대한의학회
- Kim do Y, "A nationwide seroepidemiology of hepatitis C virus infection in South Korea", Liver Int, 33, pp.586~594 (2013)
- 권근영, "Regional Distribution of Hepatitis C Virus Infection in the Republic of Korea, 2007-2011", Gut and Liver, 8(4), pp.428~432 (2014), 거트앤리버 발행위원회
- Colli A, "Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review", Am J Gastroenterol, 101, pp.513~523 (2006)
- Janjua NZ, "Health care risk factors among women and personal behaviours among men explain the high prevalence of hepatitis C virus infection in Karachi, Pakistan", J Viral Hepat, 17, pp.317~326 (2010)
- Thakral B, "Prevalence & significance of hepatitis C virus (HCV) seropositivity in blood donors", Indian J Med Res, 124, pp.431~438 (2006)
- Shin HR., "Epidemiology of hepatitis C virus in Korea", Intervirology, 49, pp.18~22 (2006)
- Guadagnino V, "Prevalence, risk factors, and genotype distribution of hepatitis C virus infection in the general population: a community-based survey in southern Italy", Hepatology, 26, pp.1006~1011 (1997)