Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis

키워드

참고문헌 (160)

1. Friedman SL, "Mechanisms of hepatic fibrogenesis", Gastroenterology, 134, pp.1655~1669 (2008)
2. Pinzani M, "Liver fibrosis : from the bench to clinical targets", Dig Liver Dis, 36, pp.231~242 (2004)
3. Comporti M, "Effect of CCl-4 in vitro and in vivo on lipid peroxidation of rat liver homogenates and subcellular fractions", Enzymologia, 29, pp.185~204 (1965)
4. Ghoshal AK, "Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: in vitro experiments", Life Sci, 4, pp.1521~1530 (1965)
5. Di Luzio NR, "Role of lipid peroxidation in the pathogenesis of the ethanol-induced fatty liver", Fed Proc, 26, pp.1436~1442 (1967)
6. Slater TF, "Free-radical mechanisms in tissue injury", Biochem J, 222, pp.1~15 (1984)
7. Albano E, "Toxicity of 1, 2-dibromoethane in isolated hepatocytes : role of lipid peroxidation", Chem Biol Interact, 50, pp.255~265 (1984)
8. Albano E, "Mechanisms responsible for carbon tetrachloride-induced perturbation of mitochondrial calcium homeostasis", FEBS Lett, 192, pp.184~188 (1985)
9. Albano E, "Free radical metabolism of alcohols by rat liver microsomes", Free Radic Res Commun, 3, pp.243~249 (1987)
10. Poli G, "The role of lipid peroxidation in liver damage", Chem Phys Lipids, 45, pp.117~142 (1987)
11. Nordmann R, "Implication of free radical mechanisms in ethanol-induced cellular injury", Free Radic Biol Med, 12, pp.219~240 (1992)
12. Nanji AA, "Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oilethanol-fed rats", Alcohol Clin Exp Res, 18, pp.1280~1285 (1994)
13. Clot P, "Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake", Gut, 35, pp.1637~1643 (1994)
14. Aleynik SI, "Increased circulating products of lipid peroxidation in patients with alcoholic liver disease", Alcohol Clin Exp Res, 22, pp.192~196 (1998)
15. Meagher EA, "Alcohol-induced generation of lipid peroxidation products in humans", J Clin Invest, 104, pp.805~813 (1999)
16. Niemelä O, "Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation", Lab Invest, 70, pp.537~546 (1994)
17. Bedossa P, "Stimulation of collagen alpha 1(I)gene expression is associated with lipid peroxidation in hepatocellular injury : a link to tissue fibrosis?", Hepatology, 19, pp.1262~1271 (1994)
18. Niemelä O, "Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease", Hepatology, 22(4 Pt 1), pp.1208~1214 (1995)
19. Kamimura S, "Increased 4-hydroxynonenal levels in experimental alcoholic liver disease : association of lipid peroxidation with liver fibrogenesis", Hepatology, 16, pp.448~453 (1992)
20. Castillo T, "Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachlorideand iron-dependent microsomal lipid peroxidation", Hepatology, 16, pp.992~996 (1992)
21. Lieber CS, "Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases", Adv Pharmacol, 38, pp.601~628 (1997)
22. Musso G, "Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis", Hepatology, 37, pp.909~916 (2003)
23. Gualdi R, "Excess iron into hepatocytes is required for activation of collagen type I gene during experimental siderosis", Gastroenterology, 107, pp.1118~1124 (1994)
24. Pietrangelo A, "Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis", Hepatology, 19, pp.714~721 (1994)
25. Farinati F, "Hepatocyte proliferative activity in chronic liver damage as assessed by the monoclonal antibody MIB1 Ki67 in archival material : the role of etiology, disease activity, iron, and lipid peroxidation", Hepatology, 23, pp.1468~1475 (1996)
26. Mansouri A, "Mitochondrial dysfunction and signaling in chronic liver diseases", Gastroenterology, 155, pp.629~647 (2018)
27. Win S, "Hepatic mitochondrial Sab(SH3BP5)plays a pivotal role in sustained JNK activation and steatohepatitis in diet-induced NASH", Hepatology, 64, pp.128A~ (2016)
28. Kang SW, "AMPK activation prevents and reverses druginduced mitochondrial and hepatocyte injury by promoting mitochondrial fusion and function", PLoS One, 11, pp.e0165638~ (2016)
29. Fiorese CJ, "The transcription factor ATF5 mediates a mammalian mitochondrial UPR", Curr Biol, 26, pp.2037~2043 (2016)
30. Du K, "Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity", Food Chem Toxic, 108(Pt A), pp.339~350 (2017)
31. Fisicaro P, "Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B", Nat Med, 23, pp.327~336 (2017)
32. Khan M, "Mitochondrial dynamics and viral infections : a close nexus", Biochim Biophys Acta, 1853(10Pt B), pp.2822~2833 (2015)
33. von Montfort C, "Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis", J Hepatol, 57, pp.852~859 (2012)
34. Demicheli V, "Inactivation and nitration of human superoxide dismutase(SOD)by fluxes of nitric oxide and superoxide", Free Radic Biol Med, 42, pp.1359~1368 (2007)
35. MacMillan-Crow LA, "Invited review : manganese superoxide dismutase in disease", Free Radical Research, 34, pp.325~336 (2001)
36. Kawada N, "Characterization of a stellate cell activation-associated protein(STAP)with peroxidase activity found in rat hepatic stellate cells", J Biol Chem, 276, pp.25318~25323 (2001)
37. Motoyama H, "Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver", Lab Invest, 94, pp.192~207 (2014)
38. Burmester T, "Cytoglobin : a novel globin type ubiquitously expressed in vertebrate tissues", Mol Biol Evol, 19, pp.416~421 (2002)
39. Sawai H, "Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans", Biochemistry, 42, pp.5133~5142 (2003)
40. Sugimoto H, "Structural basis of human cytoglobin for ligand binding", J Mol Biol, 339, pp.873~885 (2004)
41. Trent JT 3rd, "Human neuroglobin, a hexacoordinate hemoglobin that reversibly binds oxygen", J Biol Chem, 276, pp.30106~30110 (2001)
42. Hamdane D, "The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin", J Biol Chem, 278, pp.51713~51721 (2003)
43. Lechauve C, "Cytoglobin conformations and disulfide bond formation", FEBS J, 277, pp.2696~2704 (2010)
44. Nakatani K, "Cytoglobin", STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis, 2004, pp.84, 91~101
45. Fujita Y, "Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes : a novel expression site of cytoglobin", PLoS One, 9, pp.e94772~ (2014)
46. Nakatani K, "Cytoglobin", STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis, 2004, pp.84, 91~101
47. Schmidt M, "Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia", J Biol Chem, 279, pp.8063~8069 (2004)
48. Tateaki Y, "Typing of hepatic nonparenchymal cells using fibulin-2 and cytoglobin", STAP as liver fibrogenesis-related markers, 2004, pp.122, 41~49
49. Schmidt M, "Divergent distribution of cytoglobin and neuroglobin in the murine eye", Neurosci Lett, 374, pp.207~211 (2005)
50. Mammen PP, "Cytoglobin is a stress-responsive hemoprotein expressed in the developing and adult brain", J Histoche Cytochem, 54, pp.1349~1361 (2006)
51. Avivi A, "Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax", Proc Natl Acad Sci U S A, 107, pp.21570~21575 (2010)
52. Thuy le TT, "Cytoglobin deficiency promotes liver cancer development from hepatosteatosis through activation of the oxidative stress pathway", Am J Pathol, 185, pp.1045~1060 (2015)
53. Geuens E, "A globin in the nucleus!", J Biol Chem, 278, pp.30417~30420 (2003)
54. Shigematsu A, "Analyses of expression of cytoglobin by immunohistochemical studies in human tissues", Hemoglobin, 32, pp.287~296 (2008)
55. Emara M, "Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues", Cancer Cell Int, 10, pp.33~ (2010)
56. Oleksiewicz U, "Cytoglobin : biochemical, functional and clinical perspective of the newest member of the globin family", Cell Mol Life Sci, 68, pp.3869~3883 (2011)
57. Valko M, "Role of oxygen radicals in DNA damage and cancer incidence", Mol Cell Biochem, 266, pp.37~56 (2004)
58. Muriel P, "Role of oxidative stress in liver health and disease", Oxid Med Cell Longev, 2016, pp.9037051~ (2016)
59. Casini A, "Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells : role of nitric oxide", Hepatology, 25, pp.361~367 (1997)
60. Nieto N, "Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells", J Biol Chem, 277, pp.9853~9864 (2002)
61. Kupffer cells on stellate cells, "Hepatology", 2006, 1487~1501
62. Bell LN, "Bariatric surgery-induced weight loss reduces hepatic lipid peroxidation levels and affects hepatic cytochrome P-450 protein content", Ann Surg, 251, pp.1041~1048 (2010)
63. Leung TM, "CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease", J Hepatol, 58, pp.395~398 (2013)
64. Gonzalez FJ, "The 2006 Bernard B. Brodie Award Lecture", Cyp2e1Drug Metab Dispo, 35, pp.1~8 (2007)
65. Saito M, "Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1", J Med Virol, 84, pp.733~746 (2012)
66. Takano T, "Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes", J Hepatol, 55, pp.512~521 (2011)
67. Saito M, "3β-hydroxysterol δ24-reductase on the surface of hepatitis C virusrelated hepatocellular carcinoma cells can be a target for molecular targeting therapy", PLoS One, 10, pp.e0124197~ (2015)
68. Rebbani K, "HCV-induced oxidative stress : battlefield-winning strategy", Oxid Med Cell Longev, 2016, pp.7425628~ (2016)
69. Ridnour LA, "The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations", Biol Chem, 385, pp.1~10 (2004)
70. Squadrito GL, "Oxidative chemistry of nitric oxide : the roles of superoxide, peroxynitrite, and carbon dioxide", Free Radic Biol Med, 25, pp.392~403 (1998)
71. Dröge W, "Free radicals in the physiological control of cell function", Physiol Rev, 82, pp.47~95 (2002)
72. Fujita K, "Nitric oxide plays a crucial role in the development", progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model, 2010, pp.34(Suppl 1), S18~S24
73. Ottesen LH, "Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia", Free Radic Biol Med, 31, pp.790~798 (2001)
74. Iwakiri Y, "Nitric oxide in liver fibrosis : the role of inducible nitric oxide synthase", Clin Mol Hepatol, 21, pp.319~325 (2015)
75. Koruk M, "Antioxidant capacity and nitric oxide in patients with hepatic cirrhosis", Ann Clin Lab Sci, 32, pp.252~256 (2002)
76. Beyazit Y, "Nitric oxide is a potential mediator of hepatic inflammation and fibrogenesis in autoimmune hepatitis", Scand J Gastroenterol, 50, pp.204~210 (2015)
77. Grattagliano I, "Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis", World J Gastroenterol, 20, pp.5746~5759 (2014)
78. Sanz-Cameno P, "Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis", J Hepatol, 37, pp.723~729 (2002)
79. Muriel P, "Role of free radicals in liver diseases", Hepatol Int, 3, pp.526~536 (2009)
80. Lieber CS, "Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon", Gastroenterology, 106, pp.152~159 (1994)
81. Toyama T, "PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats", Biochem Biophys Res Commun, 324, pp.697~704 (2004)
82. Serviddio G, "Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress", Hepatology, 39, pp.711~720 (2004)
83. Kawada N, "Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells", Hepatology, 27, pp.1265~1274 (1998)
84. Di Pascoli M, "Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats", J Hepatol, 58, pp.904~910 (2013)
85. Eun-Sil Lee, "Resveratrol Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis in Rats", Archives of Pharmacal Research, 33(6), pp.925~932 (2010), 대한약학회
86. Chan CC, "The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury", Mol Nutr Food Res, 55, pp.1841~1849 (2011)
87. Knight TR, "Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers : protection by glutathione", J Pharmacol Exp Ther, 303, pp.468~475 (2002)
88. Du K, "Mitochondria-targeted antioxidant Mito-TEMPO protects against acetaminophen hepatotoxicity", Arch Toxicol, 91, pp.761~773 (2017)
89. Lv H, "Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK", GSK3β-Nrf2 signaling pathway, 2019, pp.17, 2~
90. Hasegawa T, "Plasma transforming growth factor-beta1 level and efficacy of alphatocopherol in patients with non-alcoholic steatohepatitis : a pilot study", Aliment Pharmacol Ther, 15, pp.1667~1672 (2001)
91. Sanyal AJ, "Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis", N Engl J Med, 362, pp.1675~1685 (2010)
92. Trent JT 3rd, "A ubiquitously expressed human hexacoordinate hemoglobin", J Biol Chem, 277, pp.19538~19545 (2002)
93. Hankeln T, "Neuroglobin and cytoglobin in search of their role in the vertebrate globin family", J Inorg Biochem, 99, pp.110~119 (2005)
94. Liu X, "Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall", Nat Commun, 8, pp.14807~ (2017)
95. Zhang S, "Cytoglobin promotes cardiac progenitor cell survival against oxidative stress via the upregulation of the NFκB", iNOS signal pathway and nitric oxide production, 2017, pp.7, 10754~
96. Thuy Le TT, "Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases", Histol Histopathol, 31, pp.257~267 (2016)
97. De Backer J, "The effect of reactive oxygen and nitrogen species on the structure of cytoglobin : a potential tumor suppressor", Redox Biol, 19, pp.1~10 (2018)
98. Hanai S, "Roles of N-and C-terminal domains in the ligand-binding properties of cytoglobin", J Inorg Biochem, 179, pp.1~9 (2018)
99. Li D, "Cytoglobin upregulated by hydrogen peroxide plays a protective role in oxidative stress", Neurochem Res, 32, pp.1375~1380 (2007)
100. Fordel E, "Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death", Neurosci Lett, 410, pp.146~151 (2006)
101. Fordel E, "Anoxia or oxygen and glucose deprivation in SH-SY5Y cells : a step closer to the unraveling of neuroglobin and cytoglobin functions", Gene, 398, pp.114~122 (2007)
102. Hodges NJ, "Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro", Mutagenesis, 23, pp.293~298 (2008)
103. Xu R, "Cytoglobin overexpression protects against damage-induced fibrosis", Mol Ther, 13, pp.1093~1100 (2006)
104. Thuy le TT, "Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice", Am J Pathol, 179, pp.1050~1060 (2011)
105. Latina A, "ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer", Oncogene, 35, pp.1493~1503 (2016)
106. Gardner PR, "Hemoglobins dioxygenate nitric oxide with high fidelity", J Inorg Biochem, 100, pp.542~550 (2006)
107. Vinogradov SN, "Diversity of globin function : enzymatic, transport, storage, and sensing", J Biol Chem, 283, pp.8773~8777 (2008)
108. Gardner AM, "Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes", J Biol Chem, 285, pp.23850~23857 (2010)
109. Smagghe BJ, "NO dioxygenase activity in hemoglobins is ubiquitous in vitro, but limited by reduction in vivo", PLoS One, 3, pp.e2039~ (2008)
110. Liu X, "Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles", FEBS J, 280, pp.3621~3631 (2013)
111. Reeder BJ, "Strong modulation of nitrite reductase activity of cytoglobin by disulfide bond oxidation : Implications for nitric oxide homeostasis", Nitric Oxide, 72, pp.16~23 (2018)
112. Jourd’heuil FL, "the hemoglobin homolog cytoglobin in smooth muscle inhibits apoptosis and regulates vascular remodeling", Arterioscler Thromb Vasc Biol, 37, pp.1944~1955 (2017)
113. Van Thuy TT, "Possible involvement of nitric oxide in enhanced liver injury and fibrogenesis during cholestasis in cytoglobin-deficient mice", Sci Rep, 7, pp.41888~ (2017)
114. Friedman SL, "Hepatic stellate cells : protean, multifunctional, and enigmatic cells of the liver", Physiol Rev, 88, pp.125~172 (2008)
115. Blaner WS, "Hepatic stellate cell lipid droplets : a specialized lipid droplet for retinoid storage", Biochim Biophys Acta, 1791, pp.467~473 (2009)
116. Bataller R, "Liver fibrosis", J Clin Invest, 115, pp.209~218 (2005)
117. Sachs BD, "p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4", cAMP, J Cell Biol, pp.2007, 177[DOI]
118. Senoo H, "Vitamin A-storing cells(stellate cells)", Vitam Horm, 75, pp.131~159 (2007)
119. Senoo H, "Stellate cells(vitamin A-storing cells)are the primary site of collagen synthesis in non-parenchymal cells in the liver", Biomed Res, 5, pp.451~458 (1984)
120. Friedman SL, "Hepatic lipocytes : the principal collagen-producing cells of normal rat liver", Proc Natl Acad Sci U S A, 82, pp.8681~8685 (1985)
121. Yokoi Y, "Immunocytochemical detection of desmin in fat-storing cells(Ito cells)", Hepatology, 4, pp.709~714 (1984)
122. Reeves HL, "Activation of hepatic stellate cells--a key issue in liver fibrosis", Front Biosci, 7, pp.d808~d826 (2002)
123. Milani S, "Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis", Gastroenterology, 98, pp.175~184 (1990)
124. Marra F, "Hepatic stellate cells and the regulation of liver inflammation", J Hepatol, 31, pp.1120~1130 (1999)
125. Heymann F, "Immunology in the liver--from homeostasis to disease", Nat Rev Gastroenterol Hepatol, 13, pp.88~110 (2016)
126. Pellicoro A, "Liver fibrosis and repair : immune regulation of wound healing in a solid organ", Nat Rev Immunol, 14, pp.181~194 (2014)
127. Brenner C, "Decoding cell death signals in liver inflammation", J Hepatol, 59, pp.583~594 (2013)
128. Paik YH, "The nicotinamide adenine dinucleotide phosphate oxidase(NOX)homologues NOX1 and NOX2", gp91(phox)mediate hepatic fibrosis in mice, 2011, pp.53, 1730~1741
129. Paik Y-H, "NADPH oxidase mediated oxidative stress in hepatic fibrogenesis", Clin Mol Hepatol, 17, pp.251~257 (2011)
130. Bataller R, "NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis", J Clin Invest, 112, pp.1383~1394 (2003)
131. Dooley S, "TGF-β in progression of liver disease", Cell Tissue Res, 347, pp.245~256 (2012)
132. Trautwein C, "Hepatic fibrosis : Concept to treatment", J Hepatol, 62, pp.S15~S24 (2015)
133. Kocabayoglu P, "β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis", J Hepatol, 63, pp.141~147 (2015)
134. Wilhelm A, "CD248", endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism, 2016, pp.65, 1175~1185
135. Hauff P, "Early to Phase II drugs currently under investigation for the treatment of liver fibrosis", Expert Opin Investig Drugs, 24, pp.309~327 (2015)
136. Lipson KE, "CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis", Fibrogenesis Tissue Repair, 5(Suppl 1), pp.S24~ (2012)
137. Fuchs BC, "Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma", Hepatology, 59, pp.1577~1590 (2014)
138. Lanaya H, "EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation", Nature Cell Biology, 16, pp.972~981 (2014)
139. Liu X, "Identification of lineage-specific transcription factors that prevent activation of hepatic stellate cells and promote fibrosis resolution", Gastroenterology, 158, pp.1728~1744.e14 (2020)
140. Yan K, "p38 mitogenactivated protein kinase and liver x receptor-α mediate the leptin effect on sterol regulatory element binding protein-1c expression in hepatic stellate cells", Mol Med, 18, pp.10~18 (2012)
141. Beaven SW, "Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease", Gastroenterology, 140, pp.1052~1062 (2011)
142. Zhou Y, "Leptin inhibits PPARγgene expression in hepatic stellate cells in the mouse model of liver damage", Mol Cell Endocrin, 323, pp.193~200 (2010)
143. De Minicis S, "Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells", Hepatology, 48, pp.2016~2026 (2008)
144. Chandrashekaran V, "Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis", BBA-Mol Basis Dis, 1862, pp.32~45 (2016)
145. Lan T, "Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation", PLoS One, 10, pp.e0129743~ (2015)
146. Liu Z, "Transforming growth factor β(TGFβ)cross-talk with the unfolded protein response is critical for hepatic stellate cell activation", J Biol Chem, 294, pp.3137~3151 (2019)
147. Khomich O, "Metabolic hallmarks of hepatic stellate cells in liver fibrosis", Cells, 9, pp.24~ (2019)
148. Issa R, "Apoptosis of hepatic stellate cells : involvement in resolution of biliary fibrosis and regulation by soluble growth factors", Gut, 48, pp.548~557 (2001)
149. Kisseleva T, "Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis", Proc Natl Acad Sci U S A, 109, pp.9448~9453 (2012)
150. El Taghdouini A, "In vitro reversion of activated primary human hepatic stellate cells", Fibrogenesis Tissue Repair, 8, pp.14~ (2015)
151. Kong X, "Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice", Hepatology, 56, pp.1150~1159 (2012)
152. Nishizawa H, "IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner", Sci Rep, 6, pp.34605~ (2016)
153. Nishi H, "Cytoglobin, a novel member of the globin family, protects kidney fibroblasts against oxidative stress under ischemic conditions", Am J Pathol, 178, pp.128~139 (2011)
154. Stone LC, "Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling", Fibrogenesis Tissue Repair, 8, pp.15~ (2015)
155. Wei H, "Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts", Biol Res, 52, pp.23~ (2019)
156. Randi EB, "The antioxidative role of cytoglobin in podocytes : implications for a role in chronic kidney disease", Antioxid Redox Signal, 32, pp.1155~1171 (2020)
157. Thi Thanh Hai N, "Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice", Sci Rep, 8, pp.17860~ (2018)
158. Fermi G, "The crystal structure of human deoxyhaemoglobin at 1. 74 A resolution", J Mol Biol, 175, pp.159~174 (1984)
159. Pesce A, "Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity", Structure, 11, pp.1087~1095 (2003)
160. Hubbard SR, "X-ray crystal structure of a recombinant human myoglobin mutant at 2. 8A resolution", J Mol Biol, 213, pp.215~218 (1990)

관련 논문AI추천