Approaches to quantifying hepatitis B virus covalently closed circular DNA

키워드

참고문헌 (108)

1. World Health Organization, "Hepatitis B", World Health Organization, ~ (2021)
2. Liaw YF, "Lamivudine for patients with chronic hepatitis B and advanced liver disease", N Engl J Med, 351, pp.1521~1531 (2004)
3. Marcellin P, "Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B", N Engl J Med, 359, pp.2442~2455 (2008)
4. Newbold JE, "The covalently closed duplex form of the hepadnavirus genome exists in situ as a heterogeneous population of viral minichromosomes", J Virol, 69, pp.3350~3357 (1995)
5. Tu T, "The lived experience of chronic hepatitis B : a broader view of its impacts and why we need a cure", Viruses, 12, pp.515~ (2020)
6. Li X, "Detection of HBV covalently closed circular DNA", Viruses, 9, pp.139~ (2017)
7. Lok AS, "Hepatitis B cure : from discovery to regulatory approval", J Hepatol, 67, pp.847~861 (2017)
8. Urban S, "The replication cycle of hepatitis B virus", J Hepatol, 52, pp.282~284 (2010)
9. Tu T, "Virus entry and its inhibition to prevent and treat hepatitis B and hepatitis D virus infections", Curr Opin Virol, 30, pp.68~79 (2018)
10. Verrier ER, "A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses", Hepatology, 63, pp.35~48 (2016)
11. Hu Q, "E-cadherin plays a role in hepatitis B virus entry through affecting glycosylated sodium-taurocholate cotransporting polypeptide distribution", Front Cell Infect Microbiol, 10, pp.74~ (2020)
12. Iwamoto M, "Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization", Proc Natl Acad Sci U S A, 116, pp.8487~8492 (2019)
13. Huang HC, "Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis", J Virol, 86, pp.9443~9453 (2012)
14. Herrscher C, "Hepatitis B virus entry into HepG2-NTCP cells requires clathrin-mediated endocytosis", Cell Microbiol, 22, pp.e13205~ (2020)
15. Li Y, "Human low-density lipoprotein receptor plays an important role in hepatitis B virus infection", PLoS Pathog, 17, pp.e1009722~ (2021)
16. Rabe B, "Nuclear import of hepatitis B virus capsids and release of the viral genome", Proc Natl Acad Sci U S A, 100, pp.9849~9854 (2003)
17. Wei L, "Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation", Nat Microbiol, 5, pp.715~726 (2020)
18. Wei L, "Hepatitis B virus cccDNA is formed through distinct repair processes of each strand", Nat Commun, 12, pp.1591~ (2021)
19. Königer C, "Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses", Proc Natl Acad Sci U S A, 111, pp.E4244~E4253 (2014)
20. Qi Y, "DNA polymerase κis a key cellular factor for the formation of covalently closed circular DNA of hepatitis B virus", PLoS Pathog, 12, pp.e1005893~ (2016)
21. Pollicino T, "Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones", Gastroenterology, 130, pp.823~837 (2006)
22. Tropberger P, "Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation", Proc Natl Acad Sci U S A, 112, pp.E5715~E5724 (2015)
23. Levrero M, "Control of cccDNA function in hepatitis B virus infection", J Hepatol, 51, pp.581~592 (2009)
24. Koepke A, "Genetic variability on the cccdna regulatory regions changes significantly in the different phases of chronic HBV infection", Hepatology, 48, pp.683A~683A (2008)
25. Volz T, "Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients", Gastroenterology, 133, pp.843~852 (2007)
26. Bartenschlager R, "The P gene product of hepatitis B virus is required as a structural component for genomic RNA encapsidation", J Virol, 64, pp.5324~5332 (1990)
27. Hirsch RC, "Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription", Nature, 344, pp.552~555 (1990)
28. Summers J, "Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate", Cell, 29, pp.403~415 (1982)
29. Bavand M, "The hepatitis B virus-associated reverse transcriptase is encoded by the viral pol gene", J Virol, 63, pp.1019~1021 (1989)
30. Seeger C, "Biochemical and genetic evidence for the hepatitis B virus replication strategy", Science, 232, pp.477~484 (1986)
31. Junker-Niepmann M, "A short cisacting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA", EMBO J, 9, pp.3389~3396 (1990)
32. Radziwill G, "Mutational analysis of the hepatitis B virus P gene product : domain structure and RNase H activity", J Virol, 64, pp.613~620 (1990)
33. Fu TB, "When retroviral reverse transcriptases reach the end of their RNA templates", J Virol, 66, pp.4271~4278 (1992)
34. Loeb DD, "Sequence-independent RNA cleavages generate the primers for plus strand DNA synthesis in hepatitis B viruses : implications for other reverse transcribing elements", EMBO J, 10, pp.3533~3540 (1991)
35. Staprans S, "Mutations affecting hepadnavirus plus-strand DNA synthesis dissociate primer cleavage from translocation and reveal the origin of linear viral DNA", J Virol, 65, pp.1255~1262 (1991)
36. Hu J, "Complete and incomplete hepatitis B virus particles : formation, function, and application", Viruses, 9, pp.56~ (2017)
37. Tu T, "HBV DNA integration : molecular mechanisms and clinical implications", Viruses, 9, pp.75~ (2017)
38. Chai N, "Properties of subviral particles of hepatitis B virus", J Virol, 82, pp.7812~7817 (2008)
39. Laras A, "Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients", Hepatology, 44, pp.694~702 (2006)
40. Nassal M, "HBV cccDNA : viral persistence reservoir and key obstacle for a cure of chronic hepatitis B", Gut, 64, pp.1972~1984 (2015)
41. Zhang YY, "Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver", Proc Natl Acad Sci U S A, 100, pp.12372~12377 (2003)
42. Werle-Lapostolle B, "Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy", Gastroenterology, 126, pp.1750~1758 (2004)
43. Liu Y, "Viral biomarkers for hepatitis B virus-related hepatocellular carcinoma occurrence and recurrence", Front Microbiol, 12, pp.665201~ (2021)
44. Dandri M, "cccDNA maintenance in chronic hepatitis B-targeting the matrix of viral replication", Infect Drug Resist, 13, pp.3873~3886 (2020)
45. Liu C, "Real-time PCR assays for hepatitis B virus DNA quantification may require two different targets", Virol J, 14, pp.94~ (2017)
46. Takeda K, "Highly sensitive detection of hepatitis B virus surface antigen by use of a semiautomated immune complex transfer chemiluminescence enzyme immunoassay", J Clin Microbiol, 51, pp.2238~2244 (2013)
47. 김세호, "ELISA for Quantitative Determination of Hepatitis B Virus Surface Antigen", Immune Network, 17(6), pp.451~459 (2017), 대한면역학회[DOI]
48. Tantiwetrueangdet A, "Reduced HBV cccDNA and HBsAg in HBV-associated hepatocellular carcinoma tissues", Med Oncol, 35, pp.127~ (2018)
49. Seto WK, "Treatment cessation of entecavir in Asian patients with hepatitis B e antigen negative chronic hepatitis B : a multicentre prospective study", Gut, 64, pp.667~672 (2015)
50. Yang N, "Relationship between serum quantitative HBsAg and HBV DNA levels in chronic hepatitis B patients", J Med Virol, 90, pp.1240~1245 (2018)
51. Fu S, "Detection of HBV DNA and antigens in HBsAg-positive patients with primary hepatocellular carcinoma", Clin Res Hepatol Gastroenterol, 41, pp.415~423 (2017)
52. Wang Q, "Serum hepatitis B surface antigen correlates with tissue covalently closed circular DNA in patients with hepatitis B-associated hepatocellular carcinoma", J Med Virol, 88, pp.244~251 (2016)
53. Lin LY, "Relationship between serum hepatitis B virus DNA and surface antigen with covalently closed circular DNA in HBeAg-negative patients", J Med Virol, 82, pp.1494~1500 (2010)
54. Wong DK, "Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA", Liver Int, 37, pp.995~1001 (2017)
55. Tu T, "Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection", J Viral Hepat, 22, pp.737~753 (2015)
56. Mason WS, "HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant", Gastroenterology, 151, pp.986~998 (2016)
57. Chan HL, "A longitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B", Hepatology, 52, pp.1232~1241 (2010)
58. Chan HL, "Serum hepatitis B surface antigen quantitation can reflect hepatitis B virus in the liver and predict treatment response", Clin Gastroenterol Hepatol, 5, pp.1462~1468 (2007)
59. Zhou T, "Hepatitis B virus e antigen production is dependent upon covalently closed circular(ccc)DNA in HepAD38 cell cultures and may serve as a cccDNA surrogate in antiviral screening assays", Antiviral Res, 72, pp.116~124 (2006)
60. Ladner SK, "Inducible expression of human hepatitis B virus(HBV)in stably transfected hepatoblastoma cells : a novel system for screening potential inhibitors of HBV replication", Antimicrob Agents Chemother, 41, pp.1715~1720 (1997)
61. Cai D, "Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation", Antimicrob Agents Chemother, 56, pp.4277~4288 (2012)
62. Cai D, "Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators", Antiviral Res, 132, pp.26~37 (2016)
63. Inoue T, "The role of hepatitis B core-related antigen", Genes(Basel), 10, pp.357~ (2019)
64. Suzuki F, "Correlation between serum hepatitis B virus core-related antigen and intrahepatic covalently closed circular DNA in chronic hepatitis B patients", J Med Virol, 81, pp.27~33 (2009)
65. Ghany MG, "Comparison of HBV RNA and hepatitis B core related antigen with conventional HBV markers among untreated adults with chronic hepatitis B in North America", Hepatology, 74, pp.2395~2409 (2021)
66. Testoni B, "Serum hepatitis B core-related antigen(HBcrAg)correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients", J Hepatol, 70, pp.615~625 (2019)
67. Hong X, "Characterization of hepatitis B precore", core-related antigens, 2021, pp.95, e01695~
68. Wang J, "Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound", J Hepatol, 65, pp.700~710 (2016)
69. Mak LY, "Review article : hepatitis B core-related antigen(HBcrAg) : an emerging marker for chronic hepatitis B virus infection", Aliment Pharmacol Ther, 47, pp.43~54 (2018)
70. Huang H, "Serum HBV DNA plus RNA shows superiority in reflecting the activity of intrahepatic cccDNA in treatment-naïve HBV-infected individuals", J Clin Virol (2018)
71. Wang J, "Relationship between serum HBV-RNA levels and intrahepatic viral as well as histologic activity markers in entecavir-treated patients", J Hepatol, 68, pp.16~24 (2018)
72. Allweiss L, "Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5", 6 complex and silencing of the viral genome in vivo, 2022, pp.71, 372~381
73. Tu T, "A novel method to precisely quantify hepatitis B virus covalently closed circular(ccc)DNA formation and maintenance", Antiviral Res, 181, pp.104865~ (2020)
74. Cai D, "A southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures", Methods Mol Biol, 1030, pp.151~161 (2013)
75. Hirt B, "Selective extraction of polyoma DNA from infected mouse cell cultures", J Mol Biol, 26, pp.365~369 (1967)
76. Arad U, "Modified Hirt procedure for rapid purification of extrachromosomal DNA from mammalian cells", Biotechniques, 24, pp.760~762 (1998)
77. Southern EM, "Detection of specific sequences among DNA fragments separated by gel electrophoresis", J Mol Biol, 98, pp.503~517 (1975)
78. Li M, "Distribution of hepatitis B virus nuclear DNA", J Virol, 92, pp.e01391~ (2017)[DOI]
79. He ML, "A new and sensitive method for the quantification of HBV cccDNA by real-time PCR", Biochem Biophys Res Commun, 295, pp.1102~1107 (2002)
80. Köck J, "Analysis of the earliest steps of hepadnavirus replication : genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity", J Virol, 67, pp.4867~4874 (1993)
81. "Plasmid-Safe ATP-Dependent DNase"[URL]
82. Qu B, "T5 exonuclease hydrolysis of hepatitis B virus replicative intermediates allows reliable quantification and fast drug efficacy testing of covalently closed circular DNA by PCR", J Virol, 92, pp.e01117~ (2018)[DOI]
83. Allweiss L, "Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo", Gut, 67, pp.542~552 (2018)
84. Gao YT, "Enhanced specificity of real-time PCR for measurement of hepatitis B virus cccDNA using restriction endonuclease and plasmid-safe ATP-dependent DNase and selective primers", J Virol Methods, 169, pp.181~187 (2010)
85. Luo J, "Identification of an intermediate in hepatitis B virus covalently closed circular(CCC)DNA formation and sensitive and selective CCC DNA detection", J Virol, 91, pp.e00539~ (2017)[DOI]
86. Marchetti AL, "New insights on molecular mechanism of hepatitis B virus covalently closed circular DNA formation", Cells, 9, pp.2430~ (2020)
87. Zehnder B, "A sensitive and specific PCR-based assay to quantify hepatitis B virus covalently closed circular(ccc)DNA while preserving cellular DNA", Bio Protoc, 11, pp.e3986~ (2021)
88. Tu T, "De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA", JHEP Rep, 3, pp.100195~ (2020)
89. Lythgoe KA, "Estimating hepatitis B virus cccDNA persistence in chronic infection", Virus Evol, 7 (2020)
90. Addison WR, "Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replication", J Virol, 76, pp.6356~6363 (2002)
91. Civitico GM, "The half-life of duck hepatitis B virus supercoiled DNA in congenitally infected primary hepatocyte cultures", Virology, 203, pp.81~89 (1994)
92. Menne S, "Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection", Hepatology, 45, pp.614~622 (2007)
93. Zhu Y, "Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis", J Virol, 75, pp.311~322 (2020)
94. Murray JM, "Dynamics of hepatitis B virus clearance in chimpanzees", Proc Natl Acad Sci U S A, 102, pp.17780~17785 (2005)
95. Lucifora J, "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA", Science, 343, pp.1221~1228 (2014)
96. Riedl T, "Hypoxia-inducible factor 1 alpha-mediated RelB", APOBEC3B down-regulation allows hepatitis B virus persistence, 2021, pp.74, 1766~1781
97. Martinez MG, "Can we cure hepatitis B virus with novel direct-acting antivirals?", Liver Int, 40(1), pp.27~34 (2020)
98. Wang L, "PS-074-A first-in-class orally available HBV cccDNA destabilizer ccc_R08achieved sustainable HBsAg and HBV DNA suppression in the HBV circle mouse model through elimination of cccDNA-like molecules in the mouse liver", J Hepatol, 70, pp.e48~ (2019)
99. Reaiche-Miller GY, "Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver", Virology, 446, pp.357~364 (2013)
100. Wang X, "Serum HBV RNA correlated with intrahepatic cccDNA more strongly than other HBV markers during peg-interferon treatment", Virol J, 18, pp.4~ (2021)
101. Inoue T, "Clinical efficacy of a novel, high-sensitivity HBcrAg assay in the management of chronic hepatitis B and HBV reactivation", J Hepatol, 75, pp.302~310 (2021)
102. Liu Y, "Serum HBV RNA quantification : useful for monitoring natural history of chronic hepatitis B infection", BMC Gastroenterol, 19, pp.53~ (2019)
103. Meier MA, "Ubiquitous expression of HBsAg from integrated HBV DNA in patients with low viral load", J Hepatol, 75, pp.840~847 (2021)
104. Aden DP, "Controlled synthesis of HBsAg in a differentiated human liver carcinomaderived cell line", Nature, 282, pp.615~616 (1979)
105. Knowles BB, "Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen", Science, 209, pp.497~499 (1980)
106. Alexander J, "Adaptation of cells derived from human malignant tumours to growth in vitro", S Afr J Med Sci, 41, pp.89~98 (1976)
107. Dejean A, "Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC", PRF, Proc Natl Acad Sci U S A, pp.1983, 80[DOI]
108. Buckwold VE, "Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication", J Virol, 70, pp.5845~5851 (1996)

관련 논문AI추천