Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease
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Nutrition and dietary interventions are a central component in the pathophysiology, but also a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our rapidly advancing understanding of how our diet influences our metabolism and focusing on specific effects on the liver, we provide a comprehensive overview of dietary concepts to counteract the increasing burden of NAFLD. Specifically, we emphasize the importance of dietary calorie restriction independently of the macronutrient composition together with adherence to a Mediterranean diet low in added fructose and processed meat that seems to exert favorable effects beyond calorie restriction. Also, we discuss intermittent fasting as a type of diet specifically tailored to decrease liver fat content and increase ketogenesis, awaiting future study results in NAFLD. Finally, personalized dietary recommendations could be powerful tools to increase the effectiveness of dietary interventions in patients with NAFLD considering the genetic background and the microbiome, among others.
Abstract
Nutrition and dietary interventions are a central component in the pathophysiology, but also a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our rapidly advancing understanding of how our diet influences our metabolism and focusing on specific effects on the liver, we provide a comprehensive overview of dietary concepts to counteract the increasing burden of NAFLD. Specifically, we emphasize the importance of dietary calorie restriction independently of the macronutrient composition together with adherence to a Mediterranean diet low in added fructose and processed meat that seems to exert favorable effects beyond calorie restriction. Also, we discuss intermittent fasting as a type of diet specifically tailored to decrease liver fat content and increase ketogenesis, awaiting future study results in NAFLD. Finally, personalized dietary recommendations could be powerful tools to increase the effectiveness of dietary interventions in patients with NAFLD considering the genetic background and the microbiome, among others.
참고문헌 (194)
- Le MH, "2019 Global NAFLD prevalence : a systematic review and meta-analysis", Clin Gastroenterol Hepatol, 20, pp.2809~2817 (2022)
- Hallsworth K, "Lifestyle modification in NAFLD", NASH : facts and figures, 2019, pp.1, 468~479
- Church T, "The obesity epidemic: a consequence of reduced energy expenditure and the uncoupling of energy intake?", Obesity(Silver Spring), 26, pp.14~16 (2018)
- Kenichi Ikejima, "Nonalcoholic fatty liver disease and alcohol-related liver disease: From clinical aspects to pathophysiological insights", Clinical and Molecular Hepatology, 26(4), pp.728~735 (2020), 대한간학회
- Semmler G, "Diet and exercise in NAFLD", NASH : beyond the obvious, 2021, pp.41, 2249~2268
- European Association for the Study of the Liver(EASL), "EASL-EASDEASO Clinical Practice Guidelines for the management of nonalcoholic fatty liver disease", J Hepatol, 64, pp.1388~1402 (2016)
- Plauth M, "ESPEN guideline on clinical nutrition in liver disease", Clin Nutr, 38, pp.485~521 (2019)
- The diagnosis, "practice guidance from the American Association for the Study of Liver Diseases", Clin Liver Dis(Hoboken), 11, pp.81~ (2018)
- Eslam M, "The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease", Hepatol Int, 14, pp.889~919 (2020)
- 강성희, "KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease", Clinical and Molecular Hepatology, 27(3), pp.363~401 (2021), 대한간학회
- Vilar-Gomez E, "Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis", Gastroenterology, 149, pp.367~378 (2015)
- Eckard C, "Prospective histopathologic evaluation of lifestyle modification in nonalcoholic fatty liver disease : a randomized trial", Therap Adv Gastroenterol, 6, pp.249~259 (2013)
- Promrat K, "Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis", Hepatology, 51, pp.121~129 (2010)
- Yaskolka Meir A, "Effect of green-Mediterranean diet on intrahepatic fat : the DIRECT PLUS randomised controlled trial", Gut, 70, pp.2085~2095 (2021)
- Magkos F, "Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity", Cell Metab, 23, pp.591~601 (2016)
- Arora C, "Effect of intensive weight-loss intervention on metabolic, ultrasound and anthropometric parameters among patients with obesity and non-alcoholic fatty liver disease : an RCT", Eur J Clin Nutr, 76, pp.1332~1338 (2022)
- Holmer M, "Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet-a randomised controlled trial", JHEP Rep, 3, pp.100256~ (2021)
- Abenavoli L, "Effect of Mediterranean diet and antioxidant formulation in non-alcoholic fatty liver disease : a randomized study", Nutrients, 9, pp.870~ (2017)
- Marin-Alejandre BA, "The metabolic and hepatic impact of two personalized dietary strategies in subjects with obesity and nonalcoholic fatty liver disease : the Fatty Liver in Obesity(FLiO)randomized controlled trial", Nutrients, 11, pp.2543~ (2019)
- Luukkonen PK, "Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease", Proc Natl Acad Sci U S A, 117, pp.7347~7354 (2020)
- Johari MI, "A randomised controlled trial on the effectiveness and adherence of modified alternate-day calorie restriction in improving activity of non-alcoholic fatty liver disease", Sci Rep, 9, pp.11232~ (2019)
- de Luis DA, "Effect of a hypocaloric diet in transaminases in nonalcoholic fatty liver disease and obese patients, relation with insulin resistance", Diabetes Res Clin Pract, 79, pp.74~78 (2008)
- van Kleef LA, "Liver stiffness not fatty liver disease is associated with atrial fibrillation : the Rotterdam study", J Hepatol, 77, pp.931~938 (2022)
- Dulai PS, "Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease : systematic review and meta-analysis", Hepatology, 65, pp.1557~1565 (2017)
- Fedchuk L, "Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease", Aliment Pharmacol Ther, 40, pp.1209~1222 (2014)
- Ma X, "Proportion of NAFLD patients with normal ALT value in overall NAFLD patients : a systematic review and meta-analysis", BMC Gastroenterol, 20, pp.10~ (2020)
- Mofrad P, "Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values", Hepatology, 37, pp.1286~1292 (2003)
- McPherson S, "Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease", Gut, 59, pp.1265~1269 (2010)
- Flanagan EW, "Calorie restriction and aging in humans", Annu Rev Nutr, 40, pp.105~133 (2020)
- Haufe S, "Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects", Hepatology, 53, pp.1504~1514 (2011)
- Kani AH, "Effects of a novel therapeutic diet on liver enzymes and coagulating factors in patients with non-alcoholic fatty liver disease : a parallel randomized trial", Nutrition, 30, pp.814~821 (2014)
- Kirk E, "Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction", Gastroenterology, 136, pp.1552~1560 (2009)
- Koutoukidis DA, "Association of weight loss interventions with changes in biomarkers of nonalcoholic fatty liver disease : a systematic review and meta-analysis", JAMA Intern Med, 179, pp.1262~1271 (2019)
- Haigh L, "The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease(NAFLD) : a systematic review and meta-analysis", Clin Nutr, 41, pp.1913~1931 (2022)
- Tsompanaki E, "Systematic review and metaanalysis : the role of diet in the development of nonalcoholic fatty liver disease", Clin Gastroenterol Hepatol (2021)[DOI]
- Yki-Järvinen H, "Dietary carbohydrates and fats in nonalcoholic fatty liver disease", Nat Rev Gastroenterol Hepatol, 18, pp.770~786 (2021)
- Ahn J, "Critical appraisal for lowcarbohydrate diet in nonalcoholic fatty liver disease : review and meta-analyses", Clin Nutr, 38, pp.2023~2030 (2019)
- Mozaffarian D, "Changes in diet and lifestyle and long-term weight gain in women and men", N Engl J Med, 364, pp.2392~2404 (2011)
- Browning JD, "Short-term weight loss and hepatic triglyceride reduction : evidence of a metabolic advantage with dietary carbohydrate restriction", Am J Clin Nutr, 93, pp.1048~1052 (2011)
- Ebbeling CB, "Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial", BMJ, 363, pp.k4583~ (2018)
- Gibson AA, "Do ketogenic diets really suppress appetite? A systematic review and meta-analysis", Obes Rev, 16, pp.64~76 (2015)
- Mardinoglu A, "An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans", Cell Metab, 27, pp.559~571 (2018)
- Goss AM, "Effects of a carbohydrate-restricted diet on hepatic lipid content in adolescents with non-alcoholic fatty liver disease : a pilot, randomized trial", Pediatr Obes, 15, pp.e12630~ (2020)
- Thomsen MN, "Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes : a randomised controlled trial", Diabetologia, 65, pp.506~517 (2022)
- Chawla S, "The effect of low-fat and low-carbohydrate diets on weight loss and lipid levels : a systematic review and meta-analysis", Nutrients, 12, pp.3774~ (2020)
- Mansoor N, "Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors : a meta-analysis of randomised controlled trials", Br J Nutr, 115, pp.466~479 (2016)
- Seidelmann SB, "Dietary carbohydrate intake and mortality : a prospective cohort study and meta-analysis", Lancet Public Health, 3, pp.e419~e428 (2018)
- Ludwig DS, "Competing paradigms of obesity pathogenesis : energy balance versus carbohydrate-insulin models", Eur J Clin Nutr, 76, pp.1209~1221 (2022)
- Hall KD, "The energy balance model of obesity : beyond calories in, calories out", Am J Clin Nutr, 115, pp.1243~1254 (2022)
- Ludwig DS, "The carbohydrate-insulin model of obesity : beyond"calories in, calories out"", JAMA Intern Med, 178, pp.1098~1103 (2018)
- Ludwig DS, "Testing the carbohydrate-insulin model of obesity in a 5-month feeding study : the perils of post-hoc participant exclusions", Eur J Clin Nutr, 74, pp.1109~1112 (2020)
- Walsh CO, "Effects of diet composition on postprandial energy availability during weight loss maintenance", PLoS One, 8, pp.e58172~ (2013)
- Shimy KJ, "Effects of dietary carbohydrate content on circulating metabolic fuel availability in the postprandial state", J Endocr Soc, 4, pp.bvaa062~ (2020)
- Utzschneider KM, "Review : the role of insulin resistance in nonalcoholic fatty liver disease", J Clin Endocrinol Metab, 91, pp.4753~4761 (2006)
- Kumashiro N, "Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease", Proc Natl Acad Sci U S A, 108, pp.16381~16385 (2011)
- Kitade H, "Nonalcoholic fatty liver disease and insulin resistance : new insights and potential new treatments", Nutrients, 9, pp.387~ (2017)
- Smith GI, "Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease", J Clin Invest, 130, pp.1453~1460 (2020)
- Luukkonen PK, "Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of nonalcoholic fatty liver disease", J Hepatol, 76, pp.526~535 (2022)
- Schwarz JM, "Shortterm alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection", J Clin Invest, 96, pp.2735~2743 (1995)
- Hudgins LC, "Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects", J Lipid Res, 41, pp.595~604 (2000)
- Wilke MS, "Synthesis of specific fatty acids contributes to VLDLtriacylglycerol composition in humans with and without type 2 diabetes", Diabetologia, 52, pp.1628~1637 (2009)
- Lambert JE, "Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease", Gastroenterology, 146, pp.726~735 (2014)
- Cohen CC, "Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease", J Clin Invest, 131, pp.e150996~ (2021)
- Ebbeling CB, "Energy requirement is higher during weight-loss maintenance in adults consuming a low-compared with highcarbohydrate diet", J Nutr, 150, pp.2009~2015 (2020)
- Rosenbaum M, "Adaptive thermogenesis in humans", Int J Obes (Lond), 34(Suppl 1), pp.S47~S55 (2010)
- Hall KD, "Obesity energetics : body weight regulation and the effects of diet composition", Gastroenterology, 152, pp.1718~1727 (2017)
- Zelber-Sagi S, "The Mediterranean dietary pattern as the diet of choice for non-alcoholic fatty liver disease : evidence and plausible mechanisms", Liver Int, 37, pp.936~949 (2017)
- Trichopoulou A, "Definitions and potential health benefits of the Mediterranean diet : views from experts around the world", BMC Med, 12, pp.112~ (2014)
- Kastorini CM, "The effect of Mediterranean diet on metabolic syndrome and its components : a meta-analysis of 50 studies and 534, 906 individuals", J Am Coll Cardiol, 57, pp.1299~1313 (2011)
- Estruch R, "Primary prevention of cardiovascular disease with a Mediterranean diet", N Engl J Med, 368, pp.1279~1290 (2013)
- Ma J, "Improved diet quality associates with reduction in liver fat, particularly in individuals with high genetic risk scores for nonalcoholic fatty liver disease", Gastroenterology, 155, pp.107~117 (2018)
- Kontogianni MD, "Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease", Clin Nutr, 33, pp.678~683 (2014)
- Baratta F, "Adherence to Mediterranean diet and non-alcoholic fatty liver disease : effect on insulin resistance", Am J Gastroenterol, 112, pp.1832~1839 (2017)
- Khalatbari-Soltani S, "The association between adherence to the Mediterranean diet and hepatic steatosis : crosssectional analysis of two independent studies, the UK Fenland Study and the Swiss CoLaus Study", BMC Med, 17, pp.19~ (2019)
- Trovato FM, "Mediterranean diet and non-alcoholic fatty liver disease : the need of extended and comprehensive interventions", Clin Nutr, 34, pp.86~88 (2015)
- Ryan MC, "The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease", J Hepatol, 59, pp.138~143 (2013)
- Misciagna G, "Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial", J Nutr Health Aging, 21, pp.404~412 (2017)
- Katsagoni CN, "Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle : a randomised controlled clinical trial", Br J Nutr, 120, pp.164~175 (2018)
- Azzu V, "Adipose tissue-liver cross talk in the control of whole-body metabolism : implications in nonalcoholic fatty liver disease", Gastroenterology, 158, pp.1899~1912 (2020)
- Gepner Y, "Effect of distinct lifestyle interventions on mobilization of fat storage pools : CENTRAL magnetic resonance imaging randomized controlled trial", Circulation, 137, pp.1143~1157 (2018)
- Gepner Y, "The beneficial effects of Mediterranean diet over lowfat diet may be mediated by decreasing hepatic fat content", J Hepatol, 71, pp.379~388 (2019)
- Davis C, "Definition of the Mediterranean diet; a literature review", Nutrients, 7, pp.9139~9153 (2015)
- Bondonno NP, "Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort", Nat Commun, 10, pp.3651~ (2019)
- Kim Y, "Flavonoid intake and mortality from cardiovascular disease and all causes : a meta-analysis of prospective cohort studies", Clin Nutr ESPEN, 20, pp.68~77 (2017)
- Salomone F, "Natural antioxidants for non-alcoholic fatty liver disease : molecular targets and clinical perspectives", Liver Int, 36, pp.5~20 (2016)
- Zhao LG, "Dietary, circulating beta-carotene and risk of all-cause mortality : a meta-analysis from prospective studies", Sci Rep, 6, pp.26983~ (2016)
- Murillo AG, "The potential of nonprovitamin A carotenoids for the prevention and treatment of non-alcoholic fatty liver disease", Biology(Basel), 5, pp.42~ (2016)
- Bjermo H, "Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity : a randomized controlled trial", Am J Clin Nutr, 95, pp.1003~1012 (2012)
- Rosqvist F, "Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans", Diabetes, 63, pp.2356~2368 (2014)
- Luukkonen PK, "Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars", Diabetes Care, 41, pp.1732~1739 (2018)
- Rosqvist F, "Overeating saturated fat promotes fatty liver and ceramides compared with polyunsaturated fat : a randomized trial", J Clin Endocrinol Metab, 104, pp.6207~6219 (2019)
- Bozzetto L, "Liver fat is reduced by an isoenergetic MUFA diet in a controlled randomized study in type 2 diabetic patients", Diabetes Care, 35, pp.1429~1435 (2012)
- Errazuriz I, "Randomized controlled trial of a MUFA or fiber-rich diet on hepatic fat in prediabetes", J Clin Endocrinol Metab, 102, pp.1765~1774 (2017)
- Delgado-Lista J, "Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet(CORDIOPREV) : a randomised controlled trial", Lancet, 399, pp.1876~1885 (2022)
- He K, "Food groups and the likelihood of non-alcoholic fatty liver disease : a systematic review and meta-analysis", Br J Nutr, 124, pp.1~13 (2020)
- Semmler G, "Nut consumption and the prevalence and severity of non-alcoholic fatty liver disease", PLoS One, 15, pp.e0244514~ (2020)
- Sindhunata DP, "Dietary fructose as a metabolic risk factor", Am J Physiol Cell Physiol, 323, pp.C847~C856 (2022)
- Tappy L, "Metabolic effects of fructose and the worldwide increase in obesity", Physiol Rev, 90, pp.23~46 (2010)
- Softic S, "Fructose and hepatic insulin resistance", Crit Rev Clin Lab Sci, 57, pp.308~322 (2020)
- Abdelmalek MF, "Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes", Hepatology, 56, pp.952~960 (2012)
- Pinnick KE, "Challenging metabolic tissues with fructose : tissue-specific and sex-specific responses", J Physiol, 597, pp.3527~3537 (2019)
- Choo VL, "Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies", BMJ, 363, pp.k4644~ (2018)
- Semnani-Azad Z, "Association of major food sources of fructose-containing sugars with incident metabolic syndrome : a systematic review and meta-analysis", JAMA Netw Open, 3, pp.e209993~ (2020)
- Lee D, "Important food sources of fructose-containing sugars and non-alcoholic fatty liver disease : a systematic review and meta-analysis of controlled trials", Nutrients, 14, pp.2846~ (2022)
- Smajis S, "Metabolic effects of a prolonged, very-highdose dietary fructose challenge in healthy subjects", Am J Clin Nutr, 111, pp.369~377 (2020)
- Schmidt KA, "Clinical intervention to reduce dietary sugar does not affect liver fat in Latino youth, regardless of PNPLA3 genotype : a randomized controlled trial", J Nutr, 152, pp.1655~1665 (2022)
- Ma J, "Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts", J Hepatol, 63, pp.462~469 (2015)
- Chen H, "Consumption of sugar-sweetened beverages has a dose-dependent effect on the risk of non-alcoholic fatty liver disease : an updated systematic review and dose-response meta-analysis", Int J Environ Res Public Health, 16, pp.2192~ (2019)
- Asgari-Taee F, "Association of sugar sweetened beverages consumption with non-alcoholic fatty liver disease : a systematic review and meta-analysis", Eur J Nutr, 58, pp.1759~1769 (2019)
- Abid A, "Soft drink consumption is associated with fatty liver disease independent of metabolic syndrome", J Hepatol, 51, pp.918~924 (2009)
- Mosca A, "Serum uric acid concentrations and fructose consumption are independently associated with NASH in children and adolescents", J Hepatol, 66, pp.1031~1036 (2017)
- Abdelmalek MF, "Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease", Hepatology, 51, pp.1961~1971 (2010)
- Geidl-Flueck B, "Fructose-and sucrose-but not glucosesweetened beverages promote hepatic de novo lipogenesis : a randomized controlled trial", J Hepatol, 75, pp.46~54 (2021)
- Schwimmer JB, "Effect of a low free sugar diet vs usual diet on nonalcoholic fatty liver disease in adolescent boys : a randomized clinical trial", JAMA, 321, pp.256~265 (2019)
- Simons N, "Effects of fructose restriction on liver steatosis(FRUITLESS); a double-blind randomized controlled trial", Am J Clin Nutr, 113, pp.391~400 (2021)
- Khodami B, "Effects of a low free sugar diet on the management of nonalcoholic fatty liver disease : a randomized clinical trial", Eur J Clin Nutr, 76, pp.987~994 (2022)
- DiStefano JK, "Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis", Cell Mol Life Sci, 77, pp.2079~2090 (2020)
- Zhao S, "Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate", Nature, 579, pp.586~591 (2020)
- Taylor SR, "Dietary fructose improves intestinal cell survival and nutrient absorption", Nature, 597, pp.263~267 (2021)
- Zelber-Sagi S, "Long term nutritional intake and the risk for non-alcoholic fatty liver disease(NAFLD) : a population based study", J Hepatol, 47, pp.711~717 (2007)
- Alferink LJ, "Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population : the Rotterdam Study", Gut, 68, pp.1088~1098 (2019)
- Hashemian M, "Red meat consumption and risk of nonalcoholic fatty liver disease in a population with low meat consumption : the Golestan Cohort Study", Am J Gastroenterol, 116, pp.1667~1675 (2021)
- Ivancovsky-Wajcman D, "High meat consumption is prospectively associated with the risk of non-alcoholic fatty liver disease and presumed significant fibrosis", Nutrients, 14, pp.3533~ (2022)
- Hashemian M, "Red meat consumption and risk of nonalcoholic fatty liver disease in a population with low red meat consumption", Curr Dev Nutr, 4(Suppl 2), pp.1413~ (2020)
- Zelber-Sagi S, "High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance", J Hepatol, 68, pp.1239~1246 (2018)
- Noureddin M, "Diet associations with nonalcoholic fatty liver disease in an ethnically diverse population : the multiethnic cohort", Hepatology, 71, pp.1940~1952 (2020)
- Rietman A, "Associations between dietary factors and markers of NAFLD in a general Dutch adult population", Eur J Clin Nutr, 72, pp.117~123 (2018)
- Kim MN, "Red meat consumption, obesity, and the risk of nonalcoholic fatty liver disease among women : evidence from mediation analysis", Clin Nutr, 41, pp.356~364 (2022)
- Alferink LJM, "Diet-dependent acid load-the missing link between an animal protein-rich diet and nonalcoholic fatty liver disease?", J Clin Endocrinol Metab, 104, pp.6325~6337 (2019)
- Ströhle A, "Estimation of the dietdependent net acid load in 229 worldwide historically studied hunter-gatherer societies", Am J Clin Nutr, 91, pp.406~412 (2010)
- Remer T, "Influence of diet on acid-base balance", Semin Dial, 13, pp.221~226 (2000)
- Vessby B, "Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women : the KANWU Study", Diabetologia, 44, pp.312~319 (2001)
- Roumans KHM, "Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance", Nat Commun, 11, pp.1891~ (2020)
- Fang X, "Dietary intake of heme iron and risk of cardiovascular disease : a doseresponse meta-analysis of prospective cohort studies", Nutr Metab Cardiovasc Dis, 25, pp.24~35 (2015)
- Yang W, "Is heme iron intake associated with risk of coronary heart disease? A meta-analysis of prospective studies", Eur J Nutr, 53, pp.395~400 (2014)
- Etemadi A, "Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study : population based cohort study", BMJ, 357, pp.j1957~ (2017)
- Koeth RA, "Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis", Nat Med, 19, pp.576~585 (2013)
- Foerster J, "The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults : a randomized crossover intervention trial", PLoS One, 9, pp.e109606~ (2014)
- Zheng W, "Well-done meat intake, heterocyclic amine exposure, and cancer risk", Nutr Cancer, 61, pp.437~446 (2009)
- Carvalho AM, "High intake of heterocyclic amines from meat is associated with oxidative stress", Br J Nutr, 113, pp.1301~1307 (2015)
- Xie Z, "Randomized controlled trial for time-restricted eating in healthy volunteers without obesity", Nat Commun, 13, pp.1003~ (2022)
- Duregon E, "Intermittent fasting : from calories to time restriction", Geroscience, 43, pp.1083~1092 (2021)
- de Cabo R, "Effects of intermittent fasting on health, aging, and disease", N Engl J Med, 381, pp.2541~2551 (2019)
- Saran AR, "Circadian rhythms in the pathogenesis and treatment of fatty liver disease", Gastroenterology, 158, pp.1948~1966 (2020)
- Queiroz JDN, "Time-restricted eating and circadian rhythms : the biological clock is ticking", Crit Rev Food Sci Nutr, 61, pp.2863~2875 (2021)
- Stekovic S, "Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans", Cell Metab, 30, pp.462~476 (2019)
- Patikorn C, "Intermittent fasting and obesity-related health outcomes : an umbrella review of meta-analyses of randomized clinical trials", JAMA Netw Open, 4, pp.e2139558~ (2021)
- Cai H, "Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease : a randomised controlled trial", BMC Gastroenterol, 19, pp.219~ (2019)
- Kord Varkaneh H, "Effects of the 5 : 2intermittent fasting diet on non-alcoholic fatty liver disease : a randomized controlled trial", Front Nutr, 9, pp.948655~ (2022)
- Xiao Y, "Effect of 5 : 2 fasting diet on liver fat content in patients with type 2 diabetic with nonalcoholic fatty liver disease", Metab Syndr Relat Disord, 20, pp.459~465 (2022)
- Aliasghari F, "The effects of Ramadan fasting on body composition, blood pressure, glucose metabolism, and markers of inflammation in NAFLD patients : an observational trial", J Am Coll Nutr, 36, pp.640~645 (2017)
- Mari A, "The impact of Ramadan fasting on fatty liver disease severity : a retrospective case control study from Israel", Isr Med Assoc J, 23, pp.94~98 (2021)
- Madkour MI, "Ramadan diurnal intermittent fasting is associated with attenuated FTO gene expression in subjects with overweight and obesity : a prospective cohort study", Front Nutr, 8, pp.741811~ (2022)
- Peng S, "FTO gene polymorphisms and obesity risk : a meta-analysis", BMC Med, 9, pp.71~ (2011)
- Livingstone KM, "Associations between FTO genotype and total energy and macronutrient intake in adults : a systematic review and meta-analysis", Obes Rev, 16, pp.666~678 (2015)
- Alhamdan BA, "Alternate-day versus daily energy restriction diets : which is more effective for weight loss? A systematic review and meta-analysis", Obes Sci Pract, 2, pp.293~302 (2016)
- Trepanowski JF, "Effect of alternate-day fasting on weight loss, weight maintenance, and cardioprotection among metabolically healthy obese adults : a randomized clinical trial", JAMA Intern Med, 177, pp.930~938 (2017)
- Gu L, "Effects of intermittent fasting in human compared to a non-intervention diet and caloric restriction : a meta-analysis of randomized controlled trials", Front Nutr, 9, pp.871682~ (2022)
- Lowe DA, "Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity: the TREAT randomized clinical trial", JAMA Intern Med, 180, pp.1491~1499 (2020)
- Carter S, "Effect of intermittent compared with continuous energy restricted diet on glycemic control in patients with type 2 diabetes : a randomized noninferiority trial", JAMA Netw Open, 1, pp.e180756~ (2018)
- Corley BT, "Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia : a randomized controlled trial", Diabet Med, 35, pp.588~594 (2018)
- Tinsley GM, "Time-restricted eating and age-related muscle loss", Aging(Albany NY), 11, pp.8741~8742 (2019)
- Laurens C, "Is muscle and protein loss relevant in long-term fasting in healthy men? A prospective trial on physiological adaptations", J Cachexia Sarcopenia Muscle, 12, pp.1690~1703 (2021)
- Williamson E, "A muscle-centric perspective on intermittent fasting : a suboptimal dietary strategy for supporting muscle protein remodeling and muscle mass?", Front Nutr, 8, pp.640621~ (2021)
- Mooli RGR, "Emerging role of hepatic ketogenesis in fatty liver disease", Front Physiol, 13, pp.946474~ (2022)
- Puchalska P, "Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics", Cell Metab, 25, pp.262~284 (2017)
- Diraison F, "Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease", Diabetes Metab, 29, pp.478~485 (2003)
- Fletcher JA, "Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver", JCI Insight, 5, pp.e127737~ (2019)
- Miller VJ, "Nutritional ketosis and mitohormesis : potential implications for mitochondrial function and human health", J Nutr Metab, 2018, pp.5157645~ (2018)
- Newman JC, "β-Hydroxybutyrate : a signaling metabolite", Annu Rev Nutr, 37, pp.51~76 (2017)
- d’Avignon DA, "Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome", JCI Insight, 3, pp.e99762~ (2018)
- Liu X, "Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα", Fgf21 signaling, 2022, pp.49, 3113~3122
- Grabacka M, "Regulation of ketone body metabolism and the role of PPARα", Int J Mol Sci, 17, pp.2093~ (2016)
- Hwi Young Kim, "Recent advances in nonalcoholic fatty liver disease metabolomics", Clinical and Molecular Hepatology, 27(4), pp.553~559 (2021), 대한간학회[DOI]
- 2020-2030 Strategic plan for NIH nutrition research - a report of the NIH Nutrition Research Task Force, "National Institutes of Health", National Institutes of Health, ~ (2020)
- Silvia Sookoian, "Precision medicine in nonalcoholic fatty liver disease: New therapeutic insights from genetics and systems biology", Clinical and Molecular Hepatology, 26(4), pp.461~475 (2020), 대한간학회[DOI]
- Zeevi D, "Personalized nutrition by prediction of glycemic responses", Cell, 163, pp.1079~1094 (2015)
- Korem T, "Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses", Cell Metab, 25, pp.1243~1253 (2017)
- Berry SE, "Human postprandial responses to food and potential for precision nutrition", Nat Med, 26, pp.964~973 (2020)
- Du F, "Resveratrol improves liver steatosis and insulin resistance in non-alcoholic fatty liver disease in association with the gut microbiota", Front Microbiol, 12, pp.611323~ (2021)
- Meroni M, "Nutrition and genetics in NAFLD : the perfect binomium", Int J Mol Sci, 21, pp.2986~ (2020)
- Davis JN, "Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption", Am J Clin Nutr, 92, pp.1522~1527 (2010)
- Sevastianova K, "Genetic variation in PNPLA3(adiponutrin)confers sensitivity to weight loss-induced decrease in liver fat in humans", Am J Clin Nutr, 94, pp.104~111 (2011)
- Shen J, "PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease", J Gastroenterol Hepatol, 30, pp.139~146 (2015)
- Van Name MA, "A low ω-6 to ω-3 PUFA ratio(n-6 : n-3PUFA)diet to treat fatty liver disease in obese youth", J Nutr, 150, pp.2314~2321 (2020)
- Santoro N, "Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6", omega3 PUFA intake, 2012, pp.7, e37827~
- Vilar-Gomez E, "Impact of the association between PNPLA3 genetic variation and dietary intake on the risk of significant fibrosis in patients with NAFLD", Am J Gastroenterol, 116, pp.994~1006 (2021)
- Rankinen T, "Genetics of food intake and eating behavior phenotypes in humans", Annu Rev Nutr, 26, pp.413~434 (2006)
- Søberg S, "FGF21 is a sugar-induced hormone associated with sweet intake and preference in humans", Cell Metab, 25, pp.1045~1053 (2017)
- Chu AY, "Novel locus including FGF21 is associated with dietary macronutrient intake", Hum Mol Genet, 22, pp.1895~1902 (2013)
- Tanaka T, "Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake", Am J Clin Nutr, 97, pp.1395~1402 (2013)
- Qi Q, "FTO genetic variants, dietary intake and body mass index : insights from 177, 330 individuals", Hum Mol Genet, 23, pp.6961~6972 (2014)
- Livingstone KM, "FTO genotype and weight loss:systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials", BMJ, 354, pp.i4707~ (2016)
- Xiang L, "FTO genotype and weight loss in diet and lifestyle interventions : a systematic review and meta-analysis", Am J Clin Nutr, 103, pp.1162~1170 (2016)
