Noninvasive serum biomarkers for liver steatosis in nonalcoholic fatty liver disease: Current and future developments
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of the population worldwide and includes nonalcoholic fatty liver, nonalcoholic steatohepatitis (NASH), and cirrhosis. Since NAFLD-associated diseases begin with steatosis, the early diagnosis of steatosis helps to prevent the progression of NASH and fibrosis. In addition, more convenient and easily diagnosable serum biomarkers are becoming crucial in disease diagnosis. In this report, we summarize the known serum biomarkers for liver steatosis and provide guidance for their application in clinical practice.
Abstract
Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of the population worldwide and includes nonalcoholic fatty liver, nonalcoholic steatohepatitis (NASH), and cirrhosis. Since NAFLD-associated diseases begin with steatosis, the early diagnosis of steatosis helps to prevent the progression of NASH and fibrosis. In addition, more convenient and easily diagnosable serum biomarkers are becoming crucial in disease diagnosis. In this report, we summarize the known serum biomarkers for liver steatosis and provide guidance for their application in clinical practice.
참고문헌 (29)
- Chalasani N, "The diagnosis and management of nonalcoholic fatty liver disease : Practice guidance from the American Association for the Study of Liver Diseases", Hepatology, 67, pp.328~357 (2018)
- Jeong-Ju Yoo, "Recent research trends and updates on nonalcoholic fatty liver disease", Clinical and Molecular Hepatology, 25(1), pp.1~11 (2019), 대한간학회
- 강성희, "KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease", Clinical and Molecular Hepatology, 27(3), pp.363~401 (2021), 대한간학회
- Lee CM, "A reappraisal of the diagnostic performance of B-mode ultrasonography for mild liver steatosis", Am J Gastroenterol (2022)[DOI]
- Hamaguchi M, "The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation", Am J Gastroenterol, 102, pp.2708~2715 (2007)
- 이준혁, "The usefulness of metabolic score for insulin resistance for the prediction of incident non-alcoholic fatty liver disease in Korean adults", Clinical and Molecular Hepatology, 28(4), pp.814~826 (2022), 대한간학회
- Michael H. Le, "Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach", Clinical and Molecular Hepatology, 28(4), pp.841~850 (2022), 대한간학회
- Nanji AA, "Serum alanine aminotransferase to aspartate aminotransferase ratio and degree of fatty liver in morbidly obese patients", Enzyme, 36, pp.266~269 (1986)
- Kunde SS, "Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women", Hepatology, 42, pp.650~656 (2005)
- Browning JD, "Prevalence of hepatic steatosis in an urban population in the United States : impact of ethnicity", Hepatology, 40, pp.1387~1395 (2004)
- Giboney PT, "Mildly elevated liver transaminase levels in the asymptomatic patient", Am Fam Physician, 71, pp.1105~1110 (2005)
- Neuschwander-Tetri BA, "Nonalcoholic steatohepatitis : summary of an AASLD Single Topic Conference", Hepatology, 37, pp.1202~1219 (2003)
- Sorrentino P, "Silent non-alcoholic fatty liver disease-a clinical-histological study", J Hepatol, 41, pp.751~757 (2004)
- Tahan V, "Serum gamma-glutamyltranspeptidase distinguishes non-alcoholic fatty liver disease at high risk", Hepatogastroenterology, 55, pp.1433~1438 (2008)
- Poynard T, "The diagnostic value of biomarkers(SteatoTest)for the prediction of liver steatosis", Comp Hepatol, 4, pp.10~ (2005)
- Poynard T, "Performance of biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in patients with severe obesity: meta analysis of individual patient data", PLoS One, 7, pp.e30325~ (2012)
- Bedogni G, "The Fatty Liver Index : a simple and accurate predictor of hepatic steatosis in the general population", BMC Gastroenterol, 6, pp.33~ (2006)
- Calori G, "Fatty liver index and mortality : the Cremona study in the 15th year of follow-up", Hepatology, 54, pp.145~152 (2011)
- Lee JH, "Hepatic steatosis index : a simple screening tool reflecting nonalcoholic fatty liver disease", Dig Liver Dis, 42, pp.503~508 (2010)
- Kotronen A, "Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors", Gastroenterology, 137, pp.865~872 (2009)
- Yip TC, "Laboratory parameter-based machine learning model for excluding non-alcoholic fatty liver disease(NAFLD)in the general population", Aliment Pharmacol Ther, 46, pp.447~456 (2017)
- Jeong S, "Development of a simple nonalcoholic fatty liver disease scoring system indicative of metabolic risks and insulin resistance", Ann Transl Med, 8, pp.1414~ (2020)
- Zhou YJ, "NAFL screening score : A basic score identifying ultrasounddiagnosed non-alcoholic fatty liver", Clin Chim Acta, 475, pp.44~50 (2017)
- Zhou YJ, "The NAFL Risk Score : A simple scoring model to predict 4-y risk for non-alcoholic fatty liver", Clin Chim Acta, 468, pp.17~24 (2017)
- Bedogni G, "A simple index of lipid overaccumulation is a good marker of liver steatosis", BMC Gastroenterol, 10, pp.98~ (2010)
- Cuthbertson DJ, "External validation of the fatty liver index and lipid accumulation product indices, using 1H-magnetic resonance spectroscopy, to identify hepatic steatosis in healthy controls and obese, insulin-resistant individuals", Eur J Endocrinol, 171, pp.561~569 (2014)
- Otgonsuren M, "Single non-invasive model to diagnose non-alcoholic fatty liver disease(NAFLD)and non-alcoholic steatohepatitis(NASH)", J Gastroenterol Hepatol, 29, pp.2006~2013 (2014)
- Jung TY, "Comparative assessment and external validation of hepatic steatosis formulae in a community-based setting", J Clin Med, 9, pp.2851~ (2020)
- Hwi Young Kim, "Recent advances in nonalcoholic fatty liver disease metabolomics", Clinical and Molecular Hepatology, 27(4), pp.553~559 (2021), 대한간학회[DOI]
