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Nonalcoholic fatty liver disease and non-liver comorbidities

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Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excess fat accumulation in the liver. It is closely associated with metabolic syndrome, and patients with NAFLD often have comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia. In addition to liver-related complications, NAFLD has been associated with a range of non-liver comorbidities, including cardiovascular disease, chronic kidney disease, and sleep apnea. Cardiovascular disease is the most common cause of mortality in patients with NAFLD, and patients with NAFLD have a higher risk of developing cardiovascular disease than the general population. Chronic kidney disease is also more common in patients with NAFLD, and the severity of NAFLD is associated with a higher risk of developing chronic kidney disease. Sleep apnea, a disorder characterized by breathing interruptions during sleep, is also more common in patients with NAFLD and is associated with the severity of NAFLD. The presence of non-liver comorbidities in patients with NAFLD has important implications for the management of this disease. Treatment of comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia may improve liver-related outcomes in patients with NAFLD. Moreover, treatment of non-liver comorbidities may also improve overall health outcomes in patients with NAFLD. Therefore, clinicians should be aware of the potential for non-liver comorbidities in patients with NAFLD and should consider the management of these comorbidities as part of the overall management of this disease.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by excess fat accumulation in the liver. It is closely associated with metabolic syndrome, and patients with NAFLD often have comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia. In addition to liver-related complications, NAFLD has been associated with a range of non-liver comorbidities, including cardiovascular disease, chronic kidney disease, and sleep apnea. Cardiovascular disease is the most common cause of mortality in patients with NAFLD, and patients with NAFLD have a higher risk of developing cardiovascular disease than the general population. Chronic kidney disease is also more common in patients with NAFLD, and the severity of NAFLD is associated with a higher risk of developing chronic kidney disease. Sleep apnea, a disorder characterized by breathing interruptions during sleep, is also more common in patients with NAFLD and is associated with the severity of NAFLD. The presence of non-liver comorbidities in patients with NAFLD has important implications for the management of this disease. Treatment of comorbidities such as obesity, type 2 diabetes mellitus, and dyslipidemia may improve liver-related outcomes in patients with NAFLD. Moreover, treatment of non-liver comorbidities may also improve overall health outcomes in patients with NAFLD. Therefore, clinicians should be aware of the potential for non-liver comorbidities in patients with NAFLD and should consider the management of these comorbidities as part of the overall management of this disease.

참고문헌 (113)

  1. Ye Q, "Global prevalence, incidence, and outcomes of non-obese or lean nonalcoholic fatty liver disease : a systematic review and metaanalysis", Lancet Gastroenterol Hepatol, 5, pp.739~752 (2020)
  2. Zou B, "Prevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999-2016", J Intern Med, 288, pp.139~151 (2020)
  3. Li J, "Meta-analysis : global prevalence, trend and forecasting of non-alcoholic fatty liver disease in children and adolescents, 2000-2021", Aliment Pharmacol Ther, 56, pp.396~406 (2022)
  4. Yu EL, "Prevalence of nonalcoholic fatty liver disease in children with obesity", J Pediatr, 207, pp.64~70 (2019)
  5. Newton KP, "Incidence of type 2 diabetes in children with nonalcoholic fatty liver disease", Clin Gastroenterol Hepatol (2022)[DOI]
  6. Younossi Z, "Global burden of NAFLD and NASH : trends, predictions, risk factors and prevention", Nat Rev Gastroenterol Hepatol, 15, pp.11~20 (2018)
  7. Paik JM, "Changes in the global burden of chronic liver diseases from 2012 to 2017 : the growing impact of NAFLD", Hepatology, 72, pp.1605~1616 (2020)
  8. Golabi P, "Burden of non-alcoholic fatty liver disease in Asia, the Middle East and North Africa : Data from Global Burden of Disease 2009-2019", J Hepatol, 75, pp.795~809 (2021)
  9. Younossi ZM, "The global epidemiology of NAFLD and NASH in patients with type 2 diabetes : A systematic review and meta-analysis", J Hepatol, 71, pp.793~801 (2019)
  10. Golabi P, "Mortality of NAFLD according to the body composition and presence of metabolic abnormalities", Hepatol Commun, 4, pp.1136~1148 (2020)
  11. Loomba R, "Mechanisms and disease consequences of nonalcoholic fatty liver disease", Cell, 184, pp.2537~2564 (2021)
  12. Sanyal AJ, "Prospective study of outcomes in adults with nonalcoholic fatty liver disease", N Engl J Med, 385, pp.1559~1569 (2021)
  13. Hagström H, "Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD", J Hepatol, 67, pp.1265~1273 (2017)
  14. Kleiner DE, "Association of histologic disease activity with progression of nonalcoholic fatty liver disease", JAMA Netw Open, 2, pp.e1912565~ (2019)
  15. Reddy YK, "Natural history of non-alcoholic fatty liver disease : a study with paired liver biopsies", J Clin Exp Hepatol, 10, pp.245~254 (2020)
  16. Wong VW, "Disease progression of non-alcoholic fatty liver disease : a prospective study with paired liver biopsies at 3 years", Gut, 59, pp.969~974 (2010)
  17. McPherson S, "Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies : implications for prognosis and clinical management", J Hepatol, 62, pp.1148~1155 (2015)
  18. Singh S, "Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis : a systematic review and meta-analysis of paired-biopsy studies", Clin Gastroenterol Hepatol, 13, pp.643~654 (2015)
  19. Adams LA, "The histological course of nonalcoholic fatty liver disease : a longitudinal study of 103 patients with sequential liver biopsies", J Hepatol, 42, pp.132~138 (2005)
  20. Park J, "NASH", Liver fibrosis prevalence and incidence of nonliver comorbidities among people with NAFLD and incidence of NAFLD by metabolic comorbidities : lessons from South Korea, 2021, pp.39, 634~645
  21. Targher G, "NAFLD and increased risk of cardiovascular disease : clinical associations, pathophysiological mechanisms and pharmacological implications", Gut, 69, pp.1691~1705 (2020)
  22. Targher G, "Nonalcoholic fatty liver disease and risk of incident cardiovascular disease : A meta-analysis", J Hepatol, 65, pp.589~600 (2016)
  23. Kasper P, "NAFLD and cardiovascular diseases : a clinical review", Clin Res Cardiol, 110, pp.921~937 (2021)
  24. Oni E, "Life’s simple 7 and nonalcoholic fatty liver disease : the multiethnic study of atherosclerosis", Am J Med, 134, pp.519~525 (2021)
  25. Plaz Torres MC, "Mediterranean diet and NAFLD : what we know and questions that still need to be answered", Nutrients, 11, pp.2971~ (2019)
  26. Lloyd-Jones DM, "Life’s essential 8: updating and enhancing the American Heart Association’s construct of cardiovascular health: a presidential advisory from the American Heart Association", Circulation, 146, pp.e18~e43 (2022)
  27. Younossi ZM, "The impact of fatigue on mortality of patients with nonalcoholic fatty liver disease : Data from National Health and nutrition examination survey 2005-2010 and 2017-2018", Liver Int, 42, pp.2646~2661 (2022)
  28. Lazarus JV, "Defining comprehensive models of care for NAFLD", Nat Rev Gastroenterol Hepatol, 18, pp.717~729 (2021)
  29. Kanwal F, "Clinical care pathway for the risk stratification and management of patients with nonalcoholic fatty liver disease", Gastroenterology, 161, pp.1657~1669 (2021)
  30. Wong VWS, "Management of NAFLD in primary care settings", Liver Int, 42, pp.2377~2389 (2022)
  31. Cusi K, "American Association of Clinical Endocrinology Clinical Practice Guideline for the diagnosis and management of nonalcoholic fatty liver disease in primary care and endocrinology clinical settings : co-sponsored by the American Association for the Study of Liver Diseases(AASLD)", Endocr Pract, 28, pp.528~562 (2022)
  32. Younossi ZM, "Clinical assessment for high-risk patients with non-alcoholic fatty liver disease in primary care and diabetology practices", Aliment Pharmacol Ther, 52, pp.513~526 (2020)
  33. Srivastava A, "Prospective evaluation of a primary care referral pathway for patients with non-alcoholic fatty liver disease", J Hepatol, 71, pp.371~378 (2019)
  34. Long MT, "AGA clinical practice update : diagnosis and management of nonalcoholic fatty liver disease in lean individuals : expert review", Gastroenterology, 163, pp.764~774 (2022)
  35. Younossi ZM, "AGA clinical practice update on lifestyle modification using diet and exercise to achieve weight loss in the management of nonalcoholic fatty liver disease : expert review", Gastroenterology, 160, pp.912~918 (2021)
  36. Simon TG, "Non-alcoholic fatty liver disease and incident major adverse cardiovascular events : results from a nationwide histology cohort", Gut, 71, pp.1867~1875 (2022)
  37. Perseghin G, "Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver", Hepatology, 47, pp.51~58 (2008)
  38. Rijzewijk LJ, "Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus", J Am Coll Cardiol, 52, pp.1793~1799 (2008)
  39. Trovato FM, "Echocardiography and NAFLD(non-alcoholic fatty liver disease)", Int J Cardiol, 221, pp.275~279 (2016)
  40. Zhang Z, "Chronic heart failure in patients with nonalcoholic fatty liver disease : prevalence, clinical features, and relevance", J Int Med Res, 46, pp.3959~3969 (2018)
  41. Valbusa F, "Non-alcoholic fatty liver disease and increased risk of all-cause mortality in elderly patients admitted for acute heart failure", Int J Cardiol, 265, pp.162~168 (2018)
  42. Mantovani A, "Heart valve calcification in patients with type 2 diabetes and nonalcoholic fatty liver disease", Metabolism, 64, pp.879~887 (2015)
  43. Bonapace S, "Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus", PLoS One, 9, pp.e88371~ (2014)
  44. Wen X, "Required warfarin dose and time in therapeutic range in patients with diagnosed Nonalcoholic Fatty Liver Disease(NAFLD)or Nonalcoholic Steatohepatitis(NASH)", PLoS One, 16, pp.e0251665~ (2021)
  45. Moshayedi H, "Association between non-alcoholic fatty liver disease and ischemic stroke", Iran J Neurol, 13, pp.144~148 (2014)
  46. Tziomalos K, "Association between nonalcoholic fatty liver disease and acute ischemic stroke severity and outcome", World J Hepatol, 5, pp.621~626 (2013)
  47. Ansel Shao Pin Tang, "Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals", Clinical and Molecular Hepatology, 28(3), pp.483~496 (2022), 대한간학회[DOI]
  48. Kim SU, "Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke", Atherosclerosis, 260, pp.156~162 (2017)
  49. Hu J, "Increased risk of cerebrovascular accident related to non-alcoholic fatty liver disease : a meta-analysis", Oncotarget, 9, pp.2752~2760 (2017)
  50. Mori T, "Non-alcoholic fatty liver disease frequency and associated factors at admission of acute stroke", Hepatol Int, 16, pp.81~88 (2022)
  51. Wu M, "Non-alcoholic fatty liver disease and stroke : A Mendelian randomization study", Eur J Neurol, 29, pp.1534~1537 (2022)
  52. Li H, "Non-alcoholic fatty liver disease is associated with stroke severity and progression of brainstem infarctions", Eur J Neurol, 25, pp.577~ (2018)
  53. Käräjämäki AJ, "Non-alcoholic fatty liver disease as a predictor of atrial fibrillation in middle-aged population(OPERA Study)", PLoS One, 10, pp.e0142937~ (2015)
  54. Mantovani A, "Nonalcoholic fatty liver disease(NAFLD)and risk of cardiac arrhythmias : a new aspect of the liver-heart axis", J Clin Transl Hepatol, 5, pp.134~141 (2017)
  55. Chen Z, "Nonalcoholic fatty liver disease : an emerging driver of cardiac arrhythmia", Circ Res, 128, pp.1747~1765 (2021)
  56. Straus SM, "Prolonged QTc interval and risk of sudden cardiac death in a population of older adults", J Am Coll Cardiol, 47, pp.362~367 (2006)
  57. Hung CS, "Nonalcoholic fatty liver disease is associated with QT prolongation in the general population", J Am Heart Assoc, 4, pp.e001820~ (2015)
  58. Mantovani A, "Cardiovascular disease and myocardial abnormalities in nonalcoholic fatty liver disease", Dig Dis Sci, 61, pp.1246~1267 (2016)
  59. Mantovani A, "Nonalcoholic fatty liver disease is associated with ventricular arrhythmias in patients with type 2 diabetes referred for clinically indicated 24-hour Holter monitoring", Diabetes Care, 39, pp.1416~1423 (2016)
  60. Shahab O, "Among patients with NAFLD, treatment of dyslipidemia does not reduce cardiovascular mortality", Hepatol Commun, 2, pp.1227~1234 (2018)
  61. Harrison SA, "Resmetirom(MGL-3196)for the treatment of non-alcoholic steatohepatitis : a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial", Lancet, 394, pp.2012~2024 (2019)
  62. Harrison SA, "A 52-week phase 3 clinical trial of resmetirom in 180 patients with well-compensated NASH cirrhosis", Hepatology, 76, pp.S90~S92 (2022)
  63. Dongiovanni P, "PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients", J Lipid Res, 60, pp.1144~1153 (2019)
  64. Kawashiri MA, "Can PCSK7 be a new pharmaceutical target?", J Atheroscler Thromb, 29, pp.1265~1267 (2022)
  65. Mantovani A, "Nonalcoholic fatty liver disease increases risk of incident chronic kidney disease : A systematic review and metaanalysis", Metabolism, 79, pp.64~76 (2018)
  66. Ciardullo S, "Liver stiffness, albuminuria and chronic kidney disease in patients with NAFLD : a systematic review and meta-analysis", Biomolecules, 12, pp.105~ (2022)
  67. Ahmed MH, "Obstructive sleep apnea syndrome and fatty liver : association or causal link?", World J Gastroenterol, 16, pp.4243~4252 (2010)
  68. Chin K, "Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients", Am J Med, 114, pp.370~376 (2003)
  69. Koo SH, "Nonalcoholic fatty liver disease : molecular mechanisms for the hepatic steatosis", Clin Mol Hepatol, 19, pp.210~215 (2013)
  70. Tilg H, "NAFLD and diabetes mellitus", Nat Rev Gastroenterol Hepatol, 14, pp.32~42 (2017)
  71. 강성희, "KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease", Clinical and Molecular Hepatology, 27(3), pp.363~401 (2021), 대한간학회
  72. Vassilatou E, "Nonalcoholic fatty liver disease and polycystic ovary syndrome", World J Gastroenterol, 20, pp.8351~8363 (2014)
  73. Paschou SA, "Nonalcoholic fatty liver disease in women with polycystic ovary syndrome", Endocrine, 67, pp.1~8 (2020)
  74. Kim JJ, "Polycystic ovary syndrome with hyperandrogenism as a risk factor for non-obese non-alcoholic fatty liver disease", Aliment Pharmacol Ther, 45, pp.1403~1412 (2017)
  75. Liu SH, "Oral contraceptive pill use is associated with reduced odds of nonalcoholic fatty liver disease in menstruating women : results from NHANES III", J Gastroenterol, 48, pp.1151~1159 (2013)
  76. Yang JD, "Patient sex, reproductive status, and synthetic hormone use associate with histologic severity of nonalcoholic steatohepatitis", Clin Gastroenterol Hepatol, 15, pp.127~131 (2017)
  77. Frøssing S, "Effect of liraglutide on ectopic fat in polycystic ovary syndrome : A randomized clinical trial", Diabetes Obes Metab, 20, pp.215~218 (2018)
  78. Sinha RA, "Direct effects of thyroid hormones on hepatic lipid metabolism", Nat Rev Endocrinol, 14, pp.259~269 (2018)
  79. Liangpunsakul S, "Is hypothyroidism a risk factor for non-alcoholic steatohepatitis?", J Clin Gastroenterol, 37, pp.340~343 (2003)
  80. Pagadala MR, "Prevalence of hypothyroidism in nonalcoholic fatty liver disease", Dig Dis Sci, 57, pp.528~534 (2012)
  81. Kim D, "Subclinical hypothyroidism and low-normal thyroid function are associated with nonalcoholic steatohepatitis and fibrosis", Clin Gastroenterol Hepatol, 16, pp.123~131 (2018)
  82. Hassan MM, "Association between hypothyroidism and hepatocellular carcinoma : a case-control study in the United States", Hepatology, 49, pp.1563~1570 (2009)
  83. Tanase DM, "Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease(HIN) : mechanisms and emerging therapeutic options", Int J Mol Sci, 21, pp.5927~ (2020)
  84. Takano S, "Effect of growth hormone on fatty liver in panhypopituitarism", Arch Dis Child, 76, pp.537~538 (1997)
  85. Hazem A, "Body composition and quality of life in adults treated with GH therapy : a systematic review and meta-analysis", Eur J Endocrinol, 166, pp.13~20 (2012)
  86. Pan CS, "Effect of recombinant human growth hormone on liver fat content in young adults with nonalcoholic fatty liver disease", Clin Endocrinol(Oxf), 94, pp.183~192 (2021)
  87. Allen AM, "The risk of incident extrahepatic cancers is higher in non-alcoholic fatty liver disease than obesity-A longitudinal cohort study", J Hepatol, 71, pp.1229~1236 (2019)
  88. Liu SS, "Association between nonalcoholic fatty liver disease and extrahepatic cancers : a systematic review and meta-analysis", Lipids Health Dis, 19, pp.118~ (2020)
  89. Wong VW, "High prevalence of colorectal neoplasm in patients with nonalcoholic steatohepatitis", Gut, 60, pp.829~836 (2011)
  90. Mantovani A, "Non-alcoholic fatty liver disease and increased risk of incident extrahepatic cancers : a meta-analysis of observational cohort studies", Gut, 71, pp.778~788 (2022)
  91. Ning L, "Association between Helicobacter pylori infection and nonalcoholic fatty liver disease : a systemic review and meta-analysis", Eur J Gastroenterol Hepatol, 31, pp.735~742 (2019)
  92. Abdel-Razik A, "Helicobacter pylori and non-alcoholic fatty liver disease: A new enigma?", Helicobacter, 23, pp.e12537~ (2018)
  93. Boursier J, "The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota", Hepatology, 63, pp.764~775 (2016)
  94. Sachdeva S, "NAFLD and COVID-19 : a pooled analysis", SN Compr Clin Med, 2, pp.2726~2729 (2020)
  95. Ji D, "Non-alcoholic fatty liver diseases in patients with COVID-19 : A retrospective study", J Hepatol, 73, pp.451~453 (2020)
  96. Adenote A, "NAFLD and infection, a nuanced relationship", Can J Gastroenterol Hepatol, 2021, pp.5556354~ (2021)
  97. Younossi ZM, "Reduced patient-reported outcome scores associate with level of fibrosis in patients with nonalcoholic steatohepatitis", Clin Gastroenterol Hepatol, 17, pp.2552~2560 (2019)
  98. Younossi ZM, "Fatigue and pruritus in patients with advanced fibrosis due to nonalcoholic steatohepatitis : the impact on patient-reported outcomes", Hepatol Commun, 4, pp.1637~1650 (2020)
  99. Younossi ZM, "The association of histologic and noninvasive tests with adverse clinical and patient-reported outcomes in patients with advanced fibrosis due to nonalcoholic steatohepatitis", Gastroenterology, 160, pp.1608~1619 (2021)
  100. Weinstein AA, "Depression in patients with nonalcoholic fatty liver disease and chronic viral hepatitis B and C", Psychosomatics, 52, pp.127~132 (2011)
  101. Zou B, "A nationwide study of inpatient admissions, mortality, and costs for patients with cirrhosis from 2005 to 2015 in the USA", Dig Dis Sci, 65, pp.1520~1528 (2020)
  102. Nguyen AL, "Rising inpatient encounters and economic burden for patients with nonalcoholic fatty liver disease in the USA", Dig Dis Sci, 64, pp.698~707 (2019)
  103. Younossi ZM, "Trends in outpatient resource utilizations and outcomes for Medicare beneficiaries with nonalcoholic fatty liver disease", J Clin Gastroenterol, 49, pp.222~227 (2015)
  104. Sayiner M, "Variables associated with inpatient and outpatient resource utilization among medicare beneficiaries with nonalcoholic fatty liver disease with or without cirrhosis", J Clin Gastroenterol, 51, pp.254~260 (2017)
  105. Gordon SC, "Disease severity is associated with higher healthcare utilization in nonalcoholic steatohepatitis medicare patients", Am J Gastroenterol, 115, pp.562~574 (2020)
  106. Romero-Gomez M, "Disease severity predicts higher healthcare costs among hospitalized nonalcoholic fatty liver disease", nonalcoholic steatohepatitis(NAFLD, Medicine(Baltimore), pp.2020, 99[DOI]
  107. Petta S, "Healthcare resource utilization and costs of nonalcoholic steatohepatitis patients with advanced liver disease in Italy", Nutr Metab Cardiovasc Dis, 30, pp.1014~1022 (2020)
  108. "J Hepatol", 2018, S32~
  109. Hagström H, "Health care costs of patients with biopsy-confirmed nonalcoholic fatty liver disease are nearly twice those of matched controls", Clin Gastroenterol Hepatol, 18, pp.1592~1599 (2020)
  110. Younossi ZM, "The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe", Hepatology, 64, pp.1577~1586 (2016)
  111. Younossi ZM, "Burden of illness and economic model for patients with nonalcoholic steatohepatitis in the United States", Hepatology, 69, pp.564~572 (2019)
  112. Tampi RP, "Modelling the economic and clinical burden of non-alcoholic steatohepatitis in East Asia : Data from Hong Kong", Hepatol Res, 50, pp.1024~1031 (2020)
  113. Papić N, "Nonalcoholic fatty liver disease as a risk factor for Clostridioides difficile infection", Eur J Clin Microbiol Infect Dis, 39, pp.569~574 (2020)

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