성조숙 증상을 보이는 여아들의 HRV의 특성 연구
A Study of the Characteristics of the HRV of the Girl Showing a Precocious Puberty
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
목적: 이 연구의 목적은 성조숙 증상을 보이는 여아들의 자율신경계의 특징을 알아보는 것이다. 방법: 2013년 1월 1일부터 2015년 12월 31일까지 OO 한방병원에 내원한 87명의 여아들 중 8세 미만인 14명을 대상으로 하였다. 2명의 성조숙군과 12명의 비성조숙군으로 나누었다. SPSS 22.0 으로 Independent samples T-test를 이용하여 두 군간의 심박변이도 차이를 연구하였다. 결과: SDNN, RMSSD는 성조숙군이 비성조숙군보다 낮았지만 통계적으로 유의하지는 않았다. TP, VLF, HF, LF는 성조숙군이 비성조숙군보다 낮았지만 통계적으로 유의하지는 않았다. LF/HF 비는 성조숙군이 비성조숙군보다 통계적으로 유의하게 높았다. HF norm는 성조숙군이 비성조숙군보다 낮았지만 통계적으로 유의하지는 않았다. LF norm는 성조숙군이 비성조숙군보다 높았지만 통계적으로 유의하지는 않았다. 결론: 성조숙증상을 보이는 여아들에게서 교감신경과 부교감신경의 불균형이 보이는 것을 알 수 있다.
Abstract
Objectives: The aim of the study was to compare the characteristics of the autonomic innervation of the heart in Precocious Puberty(PP) Girls. Methods: We studied 87 girls visiting Dongshin University Suncheon Oriental Medicine hospital from first Januarty 2013 to 31th December 2015. Among the 87 girls who were selected 14 people under the age of 8. The subjects were categorized in two groups, 2 PP girls and 12 healthy controls. We studied the difference of Heart rate variability(HRV) between two groups by Independent samples T-test using SPSS for windows(version 22.0). Results: The Standard deviation of all normal R-R intervals (SDNN), The spuare root of the sum of the spuare of difference between adjacent normal R-R intervals (RMS-SD) of PP group was non-significantly lower than non-PP group. Total power(TP), Very low frequency power(VLF), High frequency power(HF), Low frequency power(LF) of PP group was non-significantly lower than non-PP group, LF/HF ratio of PP group was significantly higher than non-PP group. Normalized high frequency power (HF norm) of PP group was non-significantly lower than non-PP group. Normalized low frequency power(LF norm) of PP was non-signficantly higher than non-PP group. Conclusion: The results suggest that imbalance of sympathetic and parasympathetic nervous system from girls of precocious puberty can be seen.
참고문헌 (39)
- Berberoğlu M, "Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management", Journal of Clinical Research in Pediatric Endocrinology, 1, pp.164~174 (2009)
- Marshall WA, "Variations in the pattern of pubertal changes in girls", Archives of Disease Childhood, 44, pp.291~303 (1969)
- The Korean Society of Pediatric Endocrin, "The Korean Society of Pediatric Endocrinolgy’s C’linical Guidelines", UihakMunhwasa, 1~23 (2011)
- "Health Insurance Review & Assessment Service"[URL]
- 이민정, "性早熟證에 관한 연구의 최근 동향 -최근 중의 잡지를 중심으로-", 대한한방소아과학회지, 22(1), pp.163~187 (2008), 대한한방소아과학회
- 김지은, "調胃升淸湯을 투여한 성조숙 증상을 주소로 한 여아의 한방치료 2례", 대한한방부인과학회지, 26(2), pp.178~187 (2013), 대한한방부인과학회
- 임영권, "성조숙증으로 진단된 여자 환아에서 호르몬 수치가 개선된 치험 1례", 대한한방소아과학회지, 28(4), pp.64~70 (2014), 대한한방소아과학회
- Sun Y, "Effect of nourishing “Yin”-removing “Fire” Chinese herbal mixture on hypothalamic kisspeptin expression in female precocious rats", J Ethnopharmacol, 127(2), pp.274~279 (2010)
- Yu CH, "Traditional Chinese medicine for idiopathicprecocious puberty: A hospital-basedretrospective observational study", Complementary Therapies in Medicine, 22, pp.258~265 (2014)
- Naoto SM, "Assessment of Measurement of Children's Bone Age Ultrasonically with Sunlight BonAge", Clinical Pediatric Endocrinology, 14, pp.17~20 (2005)
- Hong CH, "The sexual maturity rating of adolescent boys and girls in Korea", Korean Journal of Pediatrics, 37, pp.193~198 (1994)
- The Korean Society of Gynecologic Endocrinology, "Gynecologic Endocrinology", pp.211~225 (2012), Koonja publisher
- Kim SL, "Clinical and Laboratory Characteristics of Precocious Puberty in Girls", Journal of reproductive endocrinology, 1, pp.31~40 (2009)
- Tremblay L, "Precocious puberty in adolescent girls: a biomarker of later psychosocial adjustment problems", Child Psychiatry and Human Development, 36(1), pp.73~94 (2005)
- Textbook compilation committee of The Korean Association of Obstetricians and Gynecologists, "Gynecology", pp.1050~1063 (2015), Korea medical book publisher
- Bar A, "Bayley-Pinneau method of height prediction in girls with central precocious puberty: correlation with adult height", The Journal of Pediatrics, 126, pp.955~958 (1995)
- Carel JC, "Precocious puberty", The New England journal of medicine, 358(22), pp.2366~2377 (2008)
- Ranke MB, "Diagnostics of endocrine function in children and adolescents", pp.356~371 (2003), Basel
- Xhrouet-Heinrichs D, "Longitudinal study of behavioral and affective patterns in girls with central precocious puberty during long-acting triptorelin therapy", Acta Paediatrica Nurturing The Child, 86, pp.808~815 (1997)
- Carel JC, "Consensus statement on the use of gonadotropinreleasing hormone analogs in children", Pediatrics, 123, pp.752~762 (2009)
- Carel JC, "Precocious puberty and statural growth", Human Reproduction Update, 10, pp.135~147 (2004)
- Mul D, "The use of GnRH agonists in precocious puberty", European Journal of Endocrinology, 159, pp.3~8 (2008)
- Klein KO, "Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience", The Journal of Clinical Endocrinology and Metabolisom, 86, pp.4711~4716 (2001)
- Tonini G, "Side Effects of GnRH Analogue Treatment in Childhood", Journal of Pediatric Endocrinology and Metabolism, 13, pp.795~803 (2000)
- Oriental obstetrics & Gynecology, "Korean obstetrics & Gynecology(Ha)", pp.162~ (2015), EuiSeongDang publishing company
- Liu HL, "From the Liver and Kidney girls precocious puberty", Beijing Traditional Chinese Medicine, 25(2), pp.90~91 (2006)
- Gao H, "Yunpeng treatment of idiopathic precocious puberty girls experience", Hubei Journal of Traditional Chinese Medicine, 26(12), pp.13~14 (2004)
- Wang Y, "Advances in medical treatment of precocious puberty", Jilin Journal of Traditional Chinese Medicine, 27(6), pp.64~65 (2007)
- Lin YY, "A quantification model of Traditional Chinese Medicine syndromes in children with idiopathic precocious puberty and early puberty", J Tradit Chin Med, 15(33)통권 : 5, pp.630~636 (2013)
- 박미정, "한국 청소년의 성성숙 시기 및 장기간의 초경연령 추세분석", Korean Journal of Pediatrics, 49(6), pp.610~616 (2006), 대한소아과학회
- 이혜림, "심박변이도 분석을 통한 심계 허약아의 자율신경계 특성", 대한한방소아과학회지, 27(3), pp.1~11 (2013), 대한한방소아과학회
- 유은실, "계류 유산 후 한방치료 위해 내원한 환자의 Heart Rate Variability(HRV) 특성 연구", 대한한방부인과학회지, 28(3), pp.30~39 (2015), 대한한방부인과학회[DOI]
- 안지윤, "유방 섬유선종이 있는 2, 30대 여성의 HRV 특성 연구", 대한한방부인과학회지, 25(4), pp.56~65 (2012), 대한한방부인과학회
- 황재호, "산후부종과 HRV의 연관성에 관한 기초연구", 대한한방부인과학회지, 24(4), pp.186~193 (2011), 대한한방부인과학회
- 박정경, "일부 산모의 氣虛상태와 CBC 및 HRV의 관계 연구", 대한한방부인과학회지, 21(1), pp.231~241 (2008), 대한한방부인과학회
- 김민영, "전신 원적외선 조사요법(溫通療法)의 치료 효과에 대한 적외선 체열 분포와 심박변이도 검사 분석", 대한한방부인과학회지, 26(4), pp.94~106 (2013), 대한한방부인과학회
- Autonomic assessment report: a comprehensive heart rate variability analysis–interpretation guide and instructions, "Rollin M", Institue of HeartMath, 1~42 (1996)
- Aylin YD, "Heart Rate Variability in Young Women with Polycystic Ovary Syndrome", Annals of Noninvasive Electrocardiology, 11(4), pp.306~312 (2006)
- Monica BB, "Heart rate variability in adolescents with functional hypothalamic amenorrhea and anorexia nervosa", Psychiatry Research, 215(2), pp.406~409 (2014)