자궁난소질환에 대한 봉독(Bee Venom)을 활용한 국내외 연구 동향 분석
A Review of the Utility of Bee Venom on Gynecological Disorders
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목적: 봉독은 진통이나 관절염, 암, 피부질환들의 다양한 질병치료에 사용되어왔다. 이러한 봉독은 부인과영역에서 임상적으로 많이 사용되어 왔으나, 그에 대한 근거는 충분하지 않다. 본 논문에서는 논문 검색으로 통하여 여성에게 봉독사용에 대한 효과와 안정성을 알아보고, 앞으로의 연구 방향을 제시하고자 한다. 방법: 2000년 1월부터 2017년 8월까지의 국내외 논문을 검색하고, 연구 종류에 따라 분류하였다. 결과: 11편의 논문이 최종선택되었다. 1편은 ASCUS에 관한 증례보고였다. in vivo 연구는 4편으로 이 중 2편은 각각 자궁내막증과 다낭성난소증후군이었고, 나머지 2편은 자궁경부암에 대한 연구였다. in vitro 연구는 8편으로 4편은 난소암, 4편은 자궁경부암에 대한 연구였다. 11편의 논문 중 2편은 in vivo, in vitro 모두를 담은 논문이었다. 대부분의 연구에서 봉독이 부인과적 질환에 유용하다고 보고하고 있다. 결론: 봉독은 여성질환에 있어 좋은 치료제가 될 수 있음을 밝혔다. 하지만 많은 임상연구 및 잘 설계된 연구들이 더 많이 필요하다.
Abstract
Objectives: Bee Venom has been used to relieve pain and to treat various diseases, such as arthritis, cancer and skin disease. Although Bee Venom has used extensively in gynecological fields, we don’t have enough evidence with it. This study is to investigate efficacy and safety of Bee Venom on women by investigating papers, then we are going to suggest the direction of research. Methods: We searched for papers which had Bee Venom from Pubmed, OASIS, Journal of Korean Obstetrics & Gynecology, Journal of Korean Medicine up to August 2017, then classified according to the type of studies. Results: Eleven papers have been finally selected. One paper was a case report about atypical squamous cells of undetermined significance. Four papers were in vivo studies about 1 endometriosis and 1 polycystic ovarian syndrome and 2 human cervical cancer. Among eight papers that were in vitro studies, four papers were reported about ovarian cancer and four papers reported about human cervical cancer. Among ten papers that were experimental studies, two papers have been studied both in vivo and in vitro. Most of studies have shown that Bee Venom is useful for gynecological disorders. Conclusions: It has been identified that Bee Venom could be a good treatment for female disorder. However, more clinical reports and well-designed studies will be needed.
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