본문 바로가기
KERD
논문KCI 등재후보

Renal Sodium Transporters and Water Channels

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Hypertension is closely related to salt and water retention. The kidney plays an important role in the blood pressure regulation primarily to modulating tubular sodium and water reabsorption. The regulation of the salt and water balance depends upon an array of solute and water channels in the renal tubules. An altered regulation of sodium and water channels in the kidney may be related to various pathological conditions associated with altered salt and water retention. This review will discuss renal handling of sodium and water, with particular emphasis on aquaporins and renal sodium transporters and channels.

Abstract

Hypertension is closely related to salt and water retention. The kidney plays an important role in the blood pressure regulation primarily to modulating tubular sodium and water reabsorption. The regulation of the salt and water balance depends upon an array of solute and water channels in the renal tubules. An altered regulation of sodium and water channels in the kidney may be related to various pathological conditions associated with altered salt and water retention. This review will discuss renal handling of sodium and water, with particular emphasis on aquaporins and renal sodium transporters and channels.

참고문헌 (34)

  1. Greger R, "Physiology of renal sodium transport", Am J Med Sci, 319, pp.51~62 (2000)
  2. Esteva-Font C, "Molecular biology of water and salt regulation in the kidney", Cell Mol Life Sci, 69, pp.683~695 (2012)
  3. Verkman AS, "Aquaporins: translating bench research to human disease", J Exp Biol, 212(Pt 11), pp.1707~1715 (2009)
  4. McDonough AA, "Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure", Am J Physiol Regul Integr Comp Physiol, 298, pp.R851~R861 (2010)
  5. Wang X, "The regulation of proximal tubular salt transport in hypertension: an update", Curr Opin Nephrol Hypertens, 18, pp.412~420 (2009)
  6. Magyar CE, "Proximal tubule Na transporter responses are the same during acute and chronic hypertension", Am J Physiol Renal Physiol, 279, pp.F358~F369 (2000)
  7. Hoorn EJ, "The WNK kinase network regulating sodium, potassium, and blood pressure", J Am Soc Nephrol, 22, pp.605~614 (2011)
  8. Starremans PG, "Mutations in the human Na-K-2Cl cotransporter (NKCC2) identified in Bartter syndrome type I consistently result in nonfunctional transporters", J Am Soc Nephrol, 14, pp.1419~1426 (2003)
  9. Glover M, "SPAK and WNK kinases: a new target for blood pressure treatment?", Curr Opin Nephrol Hypertens, 20, pp.16~22 (2011)
  10. Yang SS, "SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction", J Am Soc Nephrol, 21, pp.1868~1877 (2010)
  11. Gamba G, "Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension", Am J Physiol Renal Physiol, 288, pp.F245~F252 (2005)
  12. Masilamani S, "Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney", J Clin Invest, 104, pp.R19~R23 (1999)
  13. Hamm LL, "Regulation of sodium transport by ENaC in the kidney", Curr Opin Nephrol Hypertens, 19, pp.98~105 (2010)
  14. Pearce D, "The role of SGK1 in hormone-regulated sodium transport", Trends Endocrinol Metab, 12, pp.341~347 (2001)
  15. Yun CC, "Glucocorticoid activation of Na(+)", H(+)exchanger isoform-3 roles of SGK1 and NHERF2, 2002, pp.277, 7676~7683
  16. Naray-Fejes-Toth A, "The sgk, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channel", Kidney Int, 57, pp.1290~1294 (2000)
  17. Farjah M, "Dietary salt regulates renal SGK1 abundance : relevance to salt sensitivity in the Dahl rat", Hypertension, 41, pp.874~878 (2003)
  18. Snyder PM, "Mechanism by which Liddle’s syndrome mutations increase activity of a human epithelial Na+ channel", Cell, 83, pp.969~978 (1995)
  19. Sun Y, "Role of the epithelial sodium channel in salt-sensitive hypertension", Acta Pharmacol Sin, 32, pp.789~797 (2011)
  20. King LS, "Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1", N Engl J Med, 345, pp.175~179 (2001)
  21. Hara-Chikuma M, "Aquaporin-1 facilitates epithelial cell migration in kidney proximal tubule", J Am Soc Nephrol, 17, pp.39~45 (2006)
  22. Boone M, "Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption", Pflugers Arch, 456, pp.1005~1024 (2008)
  23. Yasui M, "Adenylate cyclase- coupled vasopressin receptor activates AQP2 promoter via a dual effect on CRE and AP1 elements", Am J Physiol, 272, pp.F443~F450 (1997)
  24. Hasler U, "Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cells", J Biol Chem, 283, pp.6643~6661 (2008)
  25. Loonen AJ, "Aquaporin 2 mutations in nephrogenic diabetes insipidus", Semin Nephrol, 28, pp.252~265 (2008)
  26. Marples D, "Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla", J Clin Invest, 95, pp.1838~1845 (1995)
  27. Marples D, "Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex", J Clin Invest, 97, pp.1960~1968 (1996)
  28. Earm JH, "Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats", J Am Soc Nephrol, 9, pp.2181~2193 (1998)
  29. Pedersen RS, "Urinary aquaporin-2 in healthy humans and patients with liver cirrhosis and chronic heart failure during baseline conditions and after acute water load", Kidney Int, 63, pp.417~425 (2003)
  30. Apostol E, "Reduced renal medullary water channel expression in puromycin aminonucleoside-induced nephrotic syndrome", J Am Soc Nephrol, 8, pp.15~24 (1997)
  31. Ma SK, "Altered regulation of sodium-transport hormones in the kidney of rats with glycyrrhizic acid-induced hypertension", J Korean Soc Hypertens, 10, pp.35~41 (2004)
  32. Kim SW, "Increased expression of ENaC subunits and increased apical targeting of AQP2 in the kidneys of spontaneously hypertensive rats", Am J Physiol Renal Physiol, 289, pp.F957~F968 (2005)
  33. Graffe CC, "Abnormal increase in urinary aquaporin-2 excretion in response to hypertonic saline in essential hypertension", BMC Nephrol, 13, pp.15~ (2012)
  34. Bankir L, "Vasopressin V2 receptors, ENaC, and sodium reabsorption: a risk factor for hypertension?", Am J Physiol Renal Physiol, 299, pp.F917~F928 (2010)

관련 논문AI추천

이 간행물의 다른 논문 (3건)