Association between Alcohol Consumption and Hypertension
1
조회
0
다운로드
1
인용
0
참고문헌
초록
Background: Heavy alcohol consumption increases the risk of hypertension, but the effect of light to moderate alcohol consumption on the risk of hypertension remains controversial. In this cross-sectional study we aimed to identify the association between alcohol consumption and hypertension, and verify whether this association is influenced by age. Methods:Study participants were 498 men and 610 women, aged 23 to 88 years, who underwent periodic health examinations at one institute in Incheon, Korea. Results: Compared with nondrinkers, multivariate-adjusted odds ratio (OR) (95% confidence interval, CI) for hypertension according to the number of standard drinks consumed weekly was as follows: 1 to 3 drinks, OR = 1.13 (95% CI, 0.56–2.29); 4 to 10 drinks, OR = 0.51 (95% CI, 0.27–0.97); 11 to 18 drinks, OR = 1.11 (95% CI, 0.55–2.20); ≥ 19drinks per week, OR = 1.97 (95% CI, 1.18–3.29). A positive association between the prevalence of hypertension and alcohol consumption of ≥ 19 drinks per week was found for patients aged ≥ 60 years (OR = 2.47; 95% CI, 1.21–5.05), but not in patients aged < 60 years (OR = 1.54; 95% CI, 0.72–3.32). Light to moderate alcohol consumption from 4 to 10 drinks per week was significantly associated with a decreased risk of hypertension in subjects aged < 60 years (OR = 0.32; 95% CI, 0.11–0.97), but not in subjects aged ≥ 60 years (OR = 0.70; 95% CI, 0.31–1.58). Conclusions: Light to moderate alcohol consumption can decrease the risk of hypertension, whereas heavy alcohol intake is associated with an increased risk of hypertension. The association between alcohol consumption and hypertension may be changed by age.
Abstract
Background: Heavy alcohol consumption increases the risk of hypertension, but the effect of light to moderate alcohol consumption on the risk of hypertension remains controversial. In this cross-sectional study we aimed to identify the association between alcohol consumption and hypertension, and verify whether this association is influenced by age. Methods:Study participants were 498 men and 610 women, aged 23 to 88 years, who underwent periodic health examinations at one institute in Incheon, Korea. Results: Compared with nondrinkers, multivariate-adjusted odds ratio (OR) (95% confidence interval, CI) for hypertension according to the number of standard drinks consumed weekly was as follows: 1 to 3 drinks, OR = 1.13 (95% CI, 0.56–2.29); 4 to 10 drinks, OR = 0.51 (95% CI, 0.27–0.97); 11 to 18 drinks, OR = 1.11 (95% CI, 0.55–2.20); ≥ 19drinks per week, OR = 1.97 (95% CI, 1.18–3.29). A positive association between the prevalence of hypertension and alcohol consumption of ≥ 19 drinks per week was found for patients aged ≥ 60 years (OR = 2.47; 95% CI, 1.21–5.05), but not in patients aged < 60 years (OR = 1.54; 95% CI, 0.72–3.32). Light to moderate alcohol consumption from 4 to 10 drinks per week was significantly associated with a decreased risk of hypertension in subjects aged < 60 years (OR = 0.32; 95% CI, 0.11–0.97), but not in subjects aged ≥ 60 years (OR = 0.70; 95% CI, 0.31–1.58). Conclusions: Light to moderate alcohol consumption can decrease the risk of hypertension, whereas heavy alcohol intake is associated with an increased risk of hypertension. The association between alcohol consumption and hypertension may be changed by age.
참고문헌 (43)
- MacMahon S, "Alcohol consumption and hypertension", Hypertension, 9, pp.111~121 (1987)
- Thadhani R, "Prospective study of moderate alcohol consumption and risk of hypertension in young women", Archives of Internal Medicine, 162, pp.569~574 (2002)
- Klatsky AL, "Sequelae of systemic hypertension in alcohol abstainers, light drinkers, and heavy drinkers", American Journal of Cardiology, 98, pp.1063~1068 (2006)
- Fuchs FD, "Alcohol consumption and the incidence of hypertension: The Atherosclerosis Risk in Communities Study", Hypertension, 37, pp.1242~1250 (2001)
- Klatsky AL, "Alcohol and hypertension", Clinica Chimica Acta, 246, pp.91~105 (1996)
- Marmot MG, "Alcohol and blood pressure: the INTERSALT study", BMJ, 308, pp.1263~1267 (1994)
- Witteman JC, "Relation of moderate alcohol consumption and risk of systemic hypertension in women", American Journal of Cardiology, 65, pp.633~637 (1990)
- Xin X, "Effects of alcohol reduction on blood pressure: a meta-analysis of randomized controlled trials", Hypertension, 38, pp.1112~1117 (2001)
- Gillman MW, "Relationship of alcohol intake with blood pressure in young adults", Hypertension, 25, pp.1106~1110 (1995)
- Ohmori S, "Alcohol intake and future incidence of hypertension in a general Japanese population: the Hisayama study", Alcoholism: Clinical & Experimental Research, 26, pp.1010~1016 (2002)
- Wakabayashi I, "Influences of gender and age on relationships between alcohol drinking and atherosclerotic risk factors", Alcoholism: Clinical & Experimental Research, 34(1), pp.54~60 (2010)
- Canonico V, "Vigorito C, Forgione L, Tedeschi C, Guarini P, et al. Differences in blood pressure profile between young and elderly hypertensive patients", Journal of Human Hypertension, 4, pp.405~409 (1990)
- Chobanian AV, "Treatment of the elderly hypertensive patient", American Journal of Medicine, 77, pp.22~27 (1984)
- Folkow B, "Pathophysiology of hypertension: differences between young and elderly", Journal of hypertension. Supplement, 11, pp.21~24 (1993)
- Furmaga EM, "Isolated systolic hypertension in older patients", Journal of Clinical Pharmacology, 12, pp.347~358 (1993)
- Fortmann SP, "The association of blood pressure and dietary alcohol: differences by age, sex, and estrogen use", American Journal of Epidemiology, 118, pp.497~507 (1983)
- Wakabayashi I, "Effects of age on the relationship between drinking and atherosclerotic risk factors", Gerontology, 48, pp.151~156 (2002)
- Criqui MH, "Alcohol and hypertension: new insights from population studies", European Heart Journal, 8, pp.19~26 (1987)
- Potter JF, "Pressor effect of alcohol in hypertension", Lancet, 1, pp.119~122 (1984)
- Potter JF, "The pressor and metabolic effects of alcohol in normotensive subjects", Hypertension, 8, pp.625~631 (1986)
- Arkwright PD, "Plasma calcium and cortisol as predisposing factors to alcohol related blood pressure elevation", Journal of Hypertension, 2, pp.387~392 (1984)
- Abe H, "Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients", Circulation, 89, pp.2626~2633 (1994)
- Markovitz JH, "Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension", JAMA, 270, pp.2439~2443 (1993)
- Beilin LJ, "Alcohol and hypertension--kill or cure", Journal of Human Hypertension, 10(12), pp.1~5 (1996)
- Britton A, "Different measures of alcohol consumption and risk of coronary heart disease and all-cause mortality: 11-year follow-up of the Whitehall II Cohort Study", Addiction, 99, pp.109~116 (2004)
- Palmer AJ, "Alcohol intake and cardiovascular mortality in hypertensive patients: report from the Department of Health Hypertension Care Computing Project", Journal of Hypertension, 13, pp.957~964 (1995)
- Cleophas TJ, "Wine, beer and spirits and the risk of myocardial infarction: a systematic review", Biomedicine & Pharmacotherapy, 53, pp.417~423 (1999)
- Rimm EB, "Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits", BMJ, 312, pp.731~736 (1996)
- Stampfer MJ, "A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women", The New England Journal of Medicine, 319, pp.267~273 (1988)
- Hansen AS, "Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease", European Journal of Clinical Nutrition, 59, pp.449~455 (2005)
- Langer RD, "Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease", Circulation, 85, pp.910~915 (1992)
- Naissides M, "The effect of chronic consumption of red wine on cardiovascular disease risk factors in postmenopausal women", Atherosclerosis, 185, pp.438~445 (2006)
- Rimm EB, "Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors", BMJ, 319, pp.1523~1528 (1999)
- Leighton F, "A central role of eNOS in the protective effect of wine against metabolic syndrome", Cell Biochemistry & Function, 24, pp.291~298 (2006)
- Leikert JF, "Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells", Circulation, 106, pp.1614~1617 (2002)
- Bulpitt CJ, "How many alcoholic drinks might benefit an older person with hypertension", Journal of Hypertension, 23, pp.1947~1951 (2005)
- Fuchs CS, "Alcohol consumption and mortality among women", The New England Journal of Medicine, 332, pp.1245~1250 (1995)
- Jackson R, "Alcohol consumption guidelines: relative safety vs absolute risks and benefits", Lancet, 346, pp.716~ (1995)
- Hart CL, "Alcohol consumption and mortality from all causes, coronary heart disease, and stroke: results from a prospective cohort study of scottish men with 21 years of follow up", BMJ, 318, pp.1725~1729 (1999)
- McKee M, "The positive relationship between alcohol and heart disease in eastern Europe: potential physiological mechanisms", Journal of the Royal Society of Medicine, 91, pp.402~407 (1998)
- Stranges S, "Relationship of alcohol drinking pattern to risk of hypertension: a population-based study", Hypertension, 44, pp.813~819 (2004)
- Schulze MB, "Differences of blood pressure estimates between consecutive measurements on one occasion: implications for inter-study comparability of epidemiologic studies", European Journal of Epidemiology, 16, pp.891~898 (2000)
- Ahn JH, "Prevalence and associated factors of elevated blood pressure in Yonchon county", Journal of the Korean Society of Hypertension, 3, pp.77~83 (1997)