Left ventricular hypertrophy and diastolic function in children and adolescents with essential hypertension
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Introduction: Left ventricular hypertrophy and diastolic dysfunction in children and adolescents with essential hypertension tend to be underdiagnosed. The aims of this study were to investigate left ventricular hypertrophy and diastolic dysfunction in the subjects with essential hypertension defined by ambulatory blood pressure monitoring. Methods: A total of 38 Korean subjects aged 9–19 years without secondary causes of hypertension were reviewed. Ambulatory blood pressure monitoring was done in the 38 subjects to diagnose hypertension and gain the information of blood pressure pattern. The subjects were divided into two groups: a group with elevated blood pressure (BP) index (n = 29) and a group with normal BP index (n = 9). Two-dimensional ultrasound with M-mode imaging and tissue Doppler imaging were performed to measure left ventricular mass index and to assess the left ventricular diastolic dysfunction. Results: Left ventricular mass index(g/m2.7) was significantly higher in the group with elevated BP index than the group with normal BP index, but there were no differences in left ventricular diastolic dysfunction evaluated by E/A ratio and E/E’ ratio. Left ventricular mass index was related only with body mass index, while any of the ambulatory blood pressure monitoring parameters did not predict left ventricular hypertrophy. In terms of diastolic dysfunction in essential hypertension, E/E’ ratio in the subjects with left ventricular hypertrophy was higher than that in the other subjects without left ventricular hypertrophy. Discussion: Left ventricular mass index is significantly correlated with body mass index in children and adolescents with essential hypertension, and the diastolic dysfunction could be in higher risk in subjects with left ventricular hypertrophy.
Abstract
Introduction: Left ventricular hypertrophy and diastolic dysfunction in children and adolescents with essential hypertension tend to be underdiagnosed. The aims of this study were to investigate left ventricular hypertrophy and diastolic dysfunction in the subjects with essential hypertension defined by ambulatory blood pressure monitoring. Methods: A total of 38 Korean subjects aged 9–19 years without secondary causes of hypertension were reviewed. Ambulatory blood pressure monitoring was done in the 38 subjects to diagnose hypertension and gain the information of blood pressure pattern. The subjects were divided into two groups: a group with elevated blood pressure (BP) index (n = 29) and a group with normal BP index (n = 9). Two-dimensional ultrasound with M-mode imaging and tissue Doppler imaging were performed to measure left ventricular mass index and to assess the left ventricular diastolic dysfunction. Results: Left ventricular mass index(g/m2.7) was significantly higher in the group with elevated BP index than the group with normal BP index, but there were no differences in left ventricular diastolic dysfunction evaluated by E/A ratio and E/E’ ratio. Left ventricular mass index was related only with body mass index, while any of the ambulatory blood pressure monitoring parameters did not predict left ventricular hypertrophy. In terms of diastolic dysfunction in essential hypertension, E/E’ ratio in the subjects with left ventricular hypertrophy was higher than that in the other subjects without left ventricular hypertrophy. Discussion: Left ventricular mass index is significantly correlated with body mass index in children and adolescents with essential hypertension, and the diastolic dysfunction could be in higher risk in subjects with left ventricular hypertrophy.
참고문헌 (19)
- Lande MB., "Pediatric hypertension : the year in review", Clin Pediatr(Phila), 53, pp.315~319 (2014)
- Yoon EY., "Use of diagnostic tests in adolescents with essential hypertension", Arch Pediatr Adolesc Med, 166, pp.857~862 (2012)
- Pall D., "Importance of ambulatory blood pressure monitoring in adolescent hypertension", Kidney Blood Press Res, 35, pp.129~134 (2012)
- Wuhl E., "Distribution of 24-h ambulatory blood pressure in children : normalized reference values and role of body dimensions", J Hypertens, 20, pp.1995~2007 (2002)
- Daniels SR., "Indexing left ventricular mass to account for differences in body size in children and adolescents without cardiovascular disease", Am J Cardiol, 76, pp.699~701 (1995)
- 이종국, "한국 소아 청소년 정상 혈압 참고치", Korean Journal of Pediatrics, 51(1), pp.33~41 (2008), 대한소아과학회
- Franklin SS., "White-coat hypertension : new insights from recent studies", Hypertension, 62, pp.982~987 (2013)
- Cuspidi C., "Indexation of left ventricular mass to body surface area and height to allometric power of 2. 7 : is the difference limited to obese hypertensives?", J Hum Hypertens, 23, pp.728~734 (2009)
- Alpert MA., "Obesity cardiomyopathy : pathophysiology and evolution of the clinical syndrome", Am J Med Sci, 321, pp.225~236 (2001)
- Porcar-Almela M., "Left ventricular diastolic function and cardiometabolic factors in obese normotensive children", Nutr Metab Cardiovasc Dis, 25, pp.108~115 (2015)
- Agu NC., "Detection of early diastolic alterations by tissue Doppler imaging in untreated childhood-onset essential hypertension", J Am Soc Hypertens, 8, pp.303~311 (2014)
- Zamojska J., "Myocardial dysfunction measured by tissue Doppler echocardiography in children with primary arterial hypertension", Kardiol Pol, 73, pp.194~200 (2015)
- Wang M., "Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value", J Am Coll Cardiol, 41, pp.820~826 (2003)
- Pall D., "Assessment of target-organ damage in adolescent white-coat and sustained hypertensives", J Hypertens, 28, pp.2139~2144 (2010)
- 김현정, "Correlation between the morning hypertension on ambulatory blood pressure monitoring and the left ventricular mass in children", Korean Journal of Pediatrics, 57(9), pp.403~409 (2014), 대한소아과학회
- Dusan P., "Left ventricular mass and diastolic function in obese children and adolescents", Pediatr Nephrol, 30, pp.645~652 (2015)
- King-Schultz L., "Correlation of blood pressure readings from 6-hour intervals with the daytime period of 24-hour ambulatory blood pressure monitoring in pediatric patients", J Clin Hypertens(Greenwich), 14, pp.396~400 (2012)
- Suarez C., "Ambulatory blood pressure monitoring : is the daytime period enough for making clinical decisions?", Blood Press Monit, 8, pp.267~270 (2003)
- Henskens LH., "Subjective sleep disturbance increases the nocturnal blood pressure level and attenuates the correlation with target-organ damage", J Hypertens, 29, pp.242~250 (2011)