Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study
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Background: To explore the familial aggregation and heritability of hypertension in Han in Shanghai China. Methods: According to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension. Results: The prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second- degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first- degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%. Conclusion: The distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.
Abstract
Background: To explore the familial aggregation and heritability of hypertension in Han in Shanghai China. Methods: According to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension. Results: The prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second- degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first- degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%. Conclusion: The distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.
참고문헌 (30)
- Aune D, "Body mass index, abdominal fatness, and heart failure incidence and mortality : a systematic review and doseresponse meta-analysis of prospective studies", Circulation, 133(7), pp.639~649 (2016)
- Modesti PA, "Cardiovascular risk assessment in low-resource settings : a consensus document of the European Society of Hypertension Working Group on hypertension and cardiovascular risk in low resource settings", J Hypertens, 32(5), pp.951~960 (2014)
- Kotchen TA, "Obesity-related hypertension : epidemiology, pathophysiology, and clinical management", Am J Hypertens, 23(11), pp.1170~1178 (2010)
- Biino G, "Environmental and genetic contribution to hypertension prevalence : data from an epidemiological survey on Sardinian genetic isolates", PLoS One, 8, pp.e59612~ (2013)[DOI]
- Echouffo-Tcheugui JB, "Risk models to predict hypertension : a systematic review", PLoS One, 8, pp.e67370~ (2013)[DOI]
- Gu D, "Prevalence, awareness, treatment, and control of hypertension in China", Hypertension, 40, pp.920~927 (2002)
- Izawa H, "Prediction of genetic risk for hypertension", Hypertension, 41, pp.1035~1040 (2003)
- Whelton PK, "Primary prevention of hypertension : clinical and public health advisory from the National High Blood Pressure Education Program", JAMA, 288(15), pp.1882~1888 (2002)
- Kingsbury MA, "Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding", Nat Neurosci, 6, pp.1292~1299 (2003)
- Zaw KK, "Prevalence of hypertension and its associated factors in the adult population in Yangon division, Myanmar", Asia Pac J Public Health, 23(4), pp.496~506 (2011)
- Contos JJ, "Requirement for the lpa1 lysophosphatidic acid receptor gene in normal suckling behavior", Proc Natl Acad Sci U S A, 97, pp.13384~13389 (2000)
- Rafiq S, "Genome-wide association studies of hypertension: have they been fruitful?", Cardiovasc Transl Res, 3(3), pp.189~196 (2010)
- International Consortium for Blood Pressure Genome-Wide Association Studies, "Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk", Nature, 478(7367), pp.103~109 (2011)
- Levy D, "Genome-wide association study of blood pressure and hypertension", Nat Genet, 41(6), pp.677~687 (2009)
- Newton-Cheh C, "Genome-wide association study identifies eight loci associated with blood pressure", Nat Genet, 41(6), pp.666~676 (2009)
- Kato N, "Meta—analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians", Nat Genet, 43(6), pp.53~ (2011)[DOI]
- Debomoy K. Lahiri, "Genes are not our destiny: the somatic epitype bridges between the genotype and the phenotype", Nature Reviews Neuroscience, 7(12), pp.976~976 (2006), Island Press[DOI]
- Uher R, "Ne implications of gene-environmem interactions in depression:will cause inform cure?", MoI Psychiatry, 13(12), pp.1070~1078 (2008)
- EhreI GB, "Genome-wide association studies:contribution of genomic to understanding blood pressure and essential hypertension", Curr Hypertens Rep, 12, pp.17~25 (2010)
- Jeanemaitre X, "Emery and rimoin’s principles and practice of medical genetics e-dition principles of medic H genetics", pp.283~330 (2007), Churchill Livingstone Elsevier
- Yoshiji Yamada, "Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study", Int J Mol Med, 35(5), pp.1189~1198 (2015)
- Zhao Z., "Epidemiological Research Methods and Applications", pp.230~ (2005), Science Press
- Li A-l, "The effect of body mass index and its interaction with family history on hypertension : a case–control study", Clin Hypertens, 25(6), pp.1~8 (2019)
- Sham P, "Genetic epidemiology", Br Med Bull, 52, pp.408~433 (1996)
- Sundquist K, "Familial risk of ischemie and hemorrhagic stroke : a large-scale study ofthe Swedish population", Stroke, 37, pp.1668~1673 (2006)
- Zhao Z, "Epidemiological Research Methods and Applications", pp.8~ (2000), Science Press
- Dronmatsering, "Genetic basis of essential hypertension in Tibetan", Natl Med J China, 82(15), pp.1009~1012 (2002)
- Salfati E, "Direct estimates of the genomic contributions to blood pressure heritability within a populationbased cohort(ARIC)", PLoS One, 10, pp.1371~1393 (2015)
- Meng Y, "An exploration of genegene interactions and their effects on hypertension", Int J Genomics, 2017, pp.318~327 (2017)
- Waken RJ, "A review of the genetics of hypertension with a focus on gene-environment interactions", Curr Hypertens Rep, 19(3), pp.23~45 (2017)
