Factors associated with medication adherence of hypertensive patients in the Philippines: a systematic review
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Diseases of the heart and vascular system are the leading cause of mortality in the Philippines. Hypertension, the most important modifiable risk factor, has a prevalence rate of 28% and a control rate of 20%. Despite the proven efficacy of pharmacologic treatment, medication adherence is reported to be as low as 66%. While there are publications that reported factors that affect adherence in Filipinos, there are no existing research that evaluated them systematically. This review is conducted to present and synthesize findings of published literatures.Databases—PubMed, Scopus, Wiley Online library, Science Direct, JSTOR, Web of Science, SAGE journals, and Cochrane—were used to search for articles published from 2000 to 2020 that studied medication adherence in adult Filipino hypertensive population. Out of the initial 1514 articles, 15 articles met the criteria and were included in the analysis. The evidence from the included studies was summarized and discussed in a narrative review using the World Health Organization framework for adherence to long-term therapies as the framework.The factors that were positively associated with adherence were health care system-related factors: good patient-health provider relationship, accessibility of health services, use of specialty clinics and programs for hypertension, and health insurance. The factors found to be negatively associated with adherence are (1) social economic factors: younger age, single civil status, low educational attainment, and unemployment; (2) patient-related factors: low in health literacy and awareness, knowledge on hypertension, attitude towards hypertension, self-efficacy, and social support; (3) therapy-related factors: inconsistent drug regimen schedule, use of Thiazide and complementary and alternative medicines; (4) condition-related factors: low illness perception, and absence of comorbidities.Findings should be interpreted with caution because of methodological limitations. Despite this, given that health systems related factors are modifiable, they can be the focus of interventions and future researches to increase medication adherence. Clinicians may also want to screen their Filipino hypertensive patients for factors that are associated to low adherence in order to provide a tailored advice. Longitudinal research studies with heterogeneous samples of hypertensive Filipinos are imperative so that targeted interventions can be developed for the population.
Abstract
Diseases of the heart and vascular system are the leading cause of mortality in the Philippines. Hypertension, the most important modifiable risk factor, has a prevalence rate of 28% and a control rate of 20%. Despite the proven efficacy of pharmacologic treatment, medication adherence is reported to be as low as 66%. While there are publications that reported factors that affect adherence in Filipinos, there are no existing research that evaluated them systematically. This review is conducted to present and synthesize findings of published literatures.Databases—PubMed, Scopus, Wiley Online library, Science Direct, JSTOR, Web of Science, SAGE journals, and Cochrane—were used to search for articles published from 2000 to 2020 that studied medication adherence in adult Filipino hypertensive population. Out of the initial 1514 articles, 15 articles met the criteria and were included in the analysis. The evidence from the included studies was summarized and discussed in a narrative review using the World Health Organization framework for adherence to long-term therapies as the framework.The factors that were positively associated with adherence were health care system-related factors: good patient-health provider relationship, accessibility of health services, use of specialty clinics and programs for hypertension, and health insurance. The factors found to be negatively associated with adherence are (1) social economic factors: younger age, single civil status, low educational attainment, and unemployment; (2) patient-related factors: low in health literacy and awareness, knowledge on hypertension, attitude towards hypertension, self-efficacy, and social support; (3) therapy-related factors: inconsistent drug regimen schedule, use of Thiazide and complementary and alternative medicines; (4) condition-related factors: low illness perception, and absence of comorbidities.Findings should be interpreted with caution because of methodological limitations. Despite this, given that health systems related factors are modifiable, they can be the focus of interventions and future researches to increase medication adherence. Clinicians may also want to screen their Filipino hypertensive patients for factors that are associated to low adherence in order to provide a tailored advice. Longitudinal research studies with heterogeneous samples of hypertensive Filipinos are imperative so that targeted interventions can be developed for the population.
참고문헌 (40)
- "What are the leading causes of mortality in the Philippines?" (2020)[URL]
- Kearney PM, "Global burden of hypertension : analysis of worldwide data", Lancet, 365(9455), pp.217~223 (2005)[DOI]
- "The Philippine health system at a glance" (2016)[URL]
- "Investment in non-communicable diseases prevention and control will save lives and contribute to the Philippines saving up to 4.8% of annual GDP" (2019)[URL]
- Mobula LM, "Prevalence of hypertension among patients attending mobile medical clinics in the Philippines after Typhoon Haiyan", PLoS Curr, 8 (2016)
- Musini VM, "Pharmacotherapy for hypertension in the elderly", Cochrane Database Syst Rev, 4, pp.CD000028~ (2009)
- Lehane E, "An examination of the intentional and unintentional aspects of medication non-adherence in patients diagnosed with hypertension", J Clin Nurs, 16(4), pp.698~706 (2007)[DOI]
- World Health Organization, "Adherence to long-term therapies : evidence for action", World Health Organization, ~ (2003)
- Bramley TJ, "Relationship of blood pressure control to adherence with antihypertensive monotherapy in 13 managed care organizations", J Manag Care Pharm, 12(3), pp.239~245 (2006)[DOI]
- Sison J, "Philippine heart association-council on hypertension report on survey of hypertension and target organ damage(PRESYON 2-TOD*)a report on prevalence of hypertension, awareness, treatment profile and control rate", Philipp J Cardiol, 35, pp.1~9 (2007)
- de Guzman AB, "Developing a model of medication adherence among Filipino elderly", Educ Gerontol, 39(5), pp.298~313 (2013)[DOI]
- Zhao B, "Racial", ethnic differences in hypertension prevalence, treatment, and control for outpatients in northern California 2010-2012, 2015, pp.28(5), 631~639
- Ursua RA, "Predictors of hypertension among Filipino immigrants in the northeast US", J Community Health, 38(5), pp.847~855 (2013)[DOI]
- Juarez DT, "Factors affecting sustained medication adherence and its impact on health care utilization in patients with diabetes", J Pharm Health Serv Res, 4(2), pp.89~94 (2013)[DOI]
- Taira DA, "Copayment level and compliance with antihypertensive medication : analysis and policy implications for managed care", Am J Manag Care, 12(11), pp.678~683 (2006)
- Taira DA, "Antihypertensive adherence and drug class among Asian Pacific Americans", Ethn Health, 12(3), pp.265~281 (2007)[DOI]
- Paz-Pacheco E, "Diabetes care in the Philippines", J ASEAN Fed Endocr Soc, 30, pp.118~123 (2015)
- Ho B, "Mapping of medicine entitlement programs of the national government" (2015), World Health Organization
- Pinlac PA, "The status of non-communicable disease prevention and control in the Philippines : a systematic review", Acta Medica Philippina, 49, pp.19~26 (2015)
- Kim MT, "Development and testing of the Hill-Bone compliance to high blood pressure therapy scale", Prog Cardiovasc Nurs, 15(3), pp.90~96 (2000)[DOI]
- Coyoca GS, "Barriers to therapeutic regimen adherence of type II diabetes mellitus patients in Iligan City, Philippines", Proc Annu Int Conf Syiah Kuala Univ-Life Sci Eng Chapter, 3, pp.204~209 (2013)
- Morisky DE, "Predictive validity of a medication adherence measure in an outpatient setting", J Clin Hypertens(Greenwich), 10(5), pp.348~354 (2008)[DOI]
- Encabo JT, "Medication adherence among adult hypertensive patients in a local community in Caloocan City, Philippines", Thai J Pharm Sci, 41, pp.173~176 (2017)
- Hays RD, "The impact of patient adherence on health outcomes for patients with chronic disease in the medical outcomes study", J Behav Med, 17(4), pp.347~360 (1994)[DOI]
- Ku GM, "Knowledge, attitudes and perceptions of people with type 2 diabetes as related to self-management practices : results of a crosssectional study conducted in Luzon, Philippines", Chronic Illn, 11(2), pp.93~107 (2015)[DOI]
- Mamangon M, "Prevalence of medication nonadherence and level of health literacy among diagnosed hypertensives patients in a selected barangay in Manila, Philippines", 6th AHLA international health literacy conference: a health literate Asia and beyond (2018), Asian Health Literacy Association
- Palileo-Villanueva LM, "T-006 factors associated with adherence to anti-hypertensive medications among patients at the general medicine outpatient clinic, Philippine general hospital", J Hypertens, 29, pp.e52~ (2011)
- Fairman KA, "Evaluating medication adherence: which measure is right for your program?", J Manag Care Pharm, 6(6), pp.499~506 (2000)[DOI]
- Moher D, "Preferred reporting items for systematic review and meta-analysis protocols(PRISMA-P)2015 statement", Syst Rev, 4(1), pp.1~ (2015)[DOI]
- "SCImago Journal & Country Rank" (2021)[URL]
- Calano BJ, "Effectiveness of a community-based health programme on the blood pressure control, adherence and knowledge of adults with hypertension : a PRECEDE-PROCEED model approach", J Clin Nurs, 28(9-10), pp.1879~1888 (2019)[DOI]
- "The Joanna Briggs Institute critical appraisal tools for use in JBI systematic reviews: checklist for quasi-experimental studies (nonrandomized experimental studies)" (2017)[URL]
- Vandenbroucke JP, "Strengthening the reporting of observational studies in epidemiology(STROBE) : explanation and elaboration", Ann Intern Med, 147(8), pp.W163~94 (2007)[DOI]
- Dror DM, "Field based evidence of enhanced healthcare utilization among persons insured by micro health insurance units in Philippines", Health Policy, 73(3), pp.263~271 (2005)[DOI]
- Ea EE, "Self-care among Filipinos in the United States who have hypertension", Appl Nurs Res, 39, pp.71~76 (2018)[DOI]
- Pablo CG, "Medication adherence of hypertensive and diabetic patients taking complementary and alternative medicine : an intervention study", J Soc Health, 1, pp.20~30 (2018)
- Ursua RA, "A community health worker intervention to improve management of hypertension among Filipino Americans in New York and New Jersey : a pilot study", Ethn Dis, 24(1), pp.67~76 (2014)
- Ursua RA, "A community health worker intervention to improve blood pressure among Filipino Americans with hypertension : a randomized controlled trial", Prev Med Rep, 11, pp.42~48 (2018)[DOI]
- Altman DG, "The revised CONSORT statement for reporting randomized trials : explanation and elaboration", Ann Intern Med, 134(8), pp.663~694 (2001)[DOI]
- Hyre AD, "Prevalence and predictors of poor antihypertensive medication adherence in an urban health clinic setting", J Clin Hypertens(Greenwich), 9(3), pp.179~186 (2007)[DOI]
