Statement on chronotherapy for the treatment of hypertension: consensus document from the Korean society of hypertension
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving non dipping and rising patterns to dipping patterns, and improving cardiovascular prognosis. However, criticism and concerns have been raised regarding the design of these studies, such as the Hygia study, and the implausible clinical benefits in cardiovascular outcomes considering the degree of BP lowering from bedtime dosing. Studies have shown that there is no consistent evidence to suggest that routine administration of antihypertensive medications at bedtime can improve nocturnal BP and early morning BP control. However, in some cases of uncontrolled nocturnal hypertension and morning hypertension, such as in those with diabetes mellitus, chronic kidney disease, and obstructive sleep apnea, bedtime dosing has shown efficacy in reducing evening and early morning BP. The recently published the Treatment in Morning versus Evening (TIME) study failed to demonstrate benefit of bedtime dosing in reducing cardiovascular outcomes in patients with hypertension. With issues of the Hygia study and negative results from the TIME study, it is unclear at this time whether routine bedtime dosing is beneficial for reducing cardiovascular outcomes.
Abstract
Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving non dipping and rising patterns to dipping patterns, and improving cardiovascular prognosis. However, criticism and concerns have been raised regarding the design of these studies, such as the Hygia study, and the implausible clinical benefits in cardiovascular outcomes considering the degree of BP lowering from bedtime dosing. Studies have shown that there is no consistent evidence to suggest that routine administration of antihypertensive medications at bedtime can improve nocturnal BP and early morning BP control. However, in some cases of uncontrolled nocturnal hypertension and morning hypertension, such as in those with diabetes mellitus, chronic kidney disease, and obstructive sleep apnea, bedtime dosing has shown efficacy in reducing evening and early morning BP. The recently published the Treatment in Morning versus Evening (TIME) study failed to demonstrate benefit of bedtime dosing in reducing cardiovascular outcomes in patients with hypertension. With issues of the Hygia study and negative results from the TIME study, it is unclear at this time whether routine bedtime dosing is beneficial for reducing cardiovascular outcomes.
참고문헌 (34)
- Dolan E, "Superiority of ambulatory over clinic blood pressure measurement in predicting mortality : the Dublin outcome study", Hypertension, 46(1), pp.156~161 (2005)
- Salles GF, "Prognostic effect of the nocturnal blood pressure fall in hypertensive patients : the ambulatory blood pressure collaboration in patients with hypertension(ABC-H)meta-analysis", Hypertension, 67(4), pp.693~700 (2016)
- Kario K, "Nighttime blood pressure phenotype and cardiovascular prognosis : practitioner-based nationwide JAMP study", Circulation, 142(19), pp.1810~1820 (2020)
- Svensson P, "Comparative effects of ramipril on ambulatory and office blood pressures : a HOPE substudy", Hypertension, 38(6), pp.E28~E32 (2001)
- Hermida RC, "Influence of circadian time of hypertension treatment on cardiovascular risk : results of the MAPEC study", Chronobiol Int, 27(8), pp.1629~1651 (2010)
- Hermida RC, "Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes", Diabetes Care, 34(6), pp.1270~1276 (2011)
- Hermida RC, "Bedtime hypertension treatment improves cardiovascular risk reduction : the Hygia Chronotherapy Trial", Eur Heart J, 41(48), pp.4565~4576 (2020)
- Brunström M, "Missing verification of source data in hypertension research : the HYGIA PROJECT in perspective", Hypertension, 78(2), pp.555~558 (2021)
- Stergiou G, "Bedtime dosing of antihypertensive medications : systematic review and consensus statement : International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension", J Hypertens, 40(10), pp.1847~1858 (2022)
- Turgeon RD, "Lowering nighttime blood pressure with bedtime dosing of antihypertensive medications : controversies in hypertension-con side of the argument", Hypertension, 78(3), pp.871~878 (2021)
- Gumz ML, "Toward precision medicine : circadian rhythm of blood pressure and chronotherapy for hypertension – 2021 NHLBI Workshop Report", Hypertension, 80(3), pp.503~522 (2023)
- Mackenzie IS, "Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK(TIME study) : a prospective, randomised, open-label, blinded-endpoint clinical trial", Lancet, 400(10361), pp.1417~1425 (2022)
- El Jamal N, "The circadian biology of heart failure", Circ Res, 132(2), pp.223~237 (2023)
- Lecarpentier Y, "Molecular mechanisms underlying the circadian rhythm of blood pressure in normotensive subjects", Curr Hypertens Rep, 22(7), pp.50~ (2020)
- Goncharuk VD, "Neuropeptide changes in the suprachiasmatic nucleus in primary hypertension indicate functional impairment of the biological clock", J Comp Neurol, 431(3), pp.320~330 (2001)
- Scheer FA, "Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension", Hypertension, 43(2), pp.192~197 (2004)
- Parati G, "Effects of aging on 24-h dynamic baroreceptor control of heart rate in ambulant subjects", Am J Physiol, 268(4 Pt 2), pp.H1606~H1612 (1995)
- Grassi G, "Diurnal blood pressure variation and sympathetic activity", Hypertens Res, 33(5), pp.381~385 (2010)
- Kimura G, "Salt sensitivity and circadian rhythm of blood pressure : the keys to connect CKD with cardiovascular events", Hypertens Res, 33(6), pp.515~520 (2010)
- Zhao P, "Evening versus morning dosing regimen drug therapy for hypertension", Cochrane Database Syst Rev, 2011(10), pp.Cd004184~ (2011)
- Zappe DH, "Time of administration important? Morning versus evening dosing of valsartan", J Hypertens, 33(2), pp.385~392 (2015)
- Poulter NR, "Randomized crossover trial of the impact of morning or evening dosing of antihypertensive agents on 24-hour ambulatory blood pressure", Hypertension, 72(4), pp.870~873 (2018)
- White WB, "Effects of the angiotensin II receptor blockers telmisartan versus valsartan on the circadian variation of blood pressure : impact on the early morning period", Am J Hypertens, 17(4), pp.347~353 (2004)
- Burnier M, "Circadian variations in blood pressure and their implications for the administration of antihypertensive drugs : is dosing in the evening better than in the morning?", J Hypertens, 38(8), pp.1396~1406 (2020)
- Wolf J, "Non-dipping pattern of hypertension and obstructive sleep apnea syndrome", Hypertens Res, 33(9), pp.867~871 (2010)
- Yeghiazarians Y, "Obstructive sleep apnea and cardiovascular disease : a scientific statement from the American Heart Association", Circulation, 144(3), pp.e56~e67 (2021)
- Yoon M, "Prevalence and prognosis of refractory hypertension diagnosed using ambulatory blood pressure measurements", Hypertens Res, 45(8), pp.1353~1362 (2022)
- Rossen NB, "Targeting nocturnal hypertension in type 2 diabetes mellitus", Hypertension, 64(5), pp.1080~1087 (2014)
- Minutolo R, "Changing the timing of antihypertensive therapy to reduce nocturnal blood pressure in CKD : an 8-week uncontrolled trial", Am J Kidney Dis, 50(6), pp.908~917 (2007)
- Wang C, "Evening versus morning dosing regimen drug therapy for chronic kidney disease patients with hypertension in blood pressure patterns : a systematic review and meta-analysis", Intern Med J, 47(8), pp.900~906 (2017)
- Kasiakogias A, "Evening versus morning dosing of antihypertensive drugs in hypertensive patients with sleep apnoea : a cross-over study", J Hypertens, 33(2), pp.393~400 (2015)
- Mengden T, "The use of self-measured blood pressure determinations in assessing dynamics of drug compliance in a study with amlodipine once a day, morning versus evening", J Hypertens, 11(12), pp.1403~1411 (1993)
- "Editor’s Note", Eur Heart J, 41(48), pp.4564~ (2020)
- Garrison SR, "Bedtime versus morning use of antihypertensives for cardiovascular risk reduction(BedMed) : protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial", BMJ Open, 12(2), pp.e059711~ (2022)