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전자소자를 이용한 인간 감성지표 코티졸 검출에 관한 기초연구

A pilot study on measuring the human cortisol using an electronic device

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참고문헌

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주제분류감성과학

초록

The precise measurement of human emotion is of pivotal importance in the field of emotion science. Based on the perspective of psychoneuroimmunoendocrinology, human emotion is now considered to be measurable by body fluid. The biological molecule cortisol, which is known for the stress hormone, has been widely investigated to help researchers to estimate the stress loaded on human body. Until now, several measurement techniques such as High Performance Liquid Chromatography (HPLC), fluorometric assay, and reverse phase chromatography have been developed. However, since these measurements are expensive, take relatively long time for an operation, and they are not portable, they are not appropriate for POCT (point of care testing). In this paper we demonstrate the performance of a miniaturized-microwave resonant device in the measurement of cortisol. Our method has many advantages in that it requires a small volume of sample, has fast response time, is easy to operate and needs no labeling process. Besides, it will shed a light on the measurement techniques for emotion science.

Abstract

The precise measurement of human emotion is of pivotal importance in the field of emotion science. Based on the perspective of psychoneuroimmunoendocrinology, human emotion is now considered to be measurable by body fluid. The biological molecule cortisol, which is known for the stress hormone, has been widely investigated to help researchers to estimate the stress loaded on human body. Until now, several measurement techniques such as High Performance Liquid Chromatography (HPLC), fluorometric assay, and reverse phase chromatography have been developed. However, since these measurements are expensive, take relatively long time for an operation, and they are not portable, they are not appropriate for POCT (point of care testing). In this paper we demonstrate the performance of a miniaturized-microwave resonant device in the measurement of cortisol. Our method has many advantages in that it requires a small volume of sample, has fast response time, is easy to operate and needs no labeling process. Besides, it will shed a light on the measurement techniques for emotion science.

참고문헌 (14)

  1. Appel, D, "A fluorimetric assay for cortisol", Analytical and Bioanalytical Chemistry, 383(2), pp.182~186 (2005)
  2. Dalmay, C, "RF biosensor based on microwave filter for biological cell characterization", Proceeding of the 30th European Microwave Conference, pp.41~44 (2009)
  3. Gatti, R, "Urinary high performance reverse phase chromatography cortisol and cortisone analyses before and at the end of a race in elite cyclists", Journal of Chromatography B, 824(1), pp.51~56 (2005)
  4. Hauer, D, "Traumatic memories, post-traumatic stress disorder and serum cortisol levels in long-term survivors of the acute respiratory distress syndrome", Brain Research, 1293(1), pp.114~120 (2009)
  5. 정효일, "감성 진단칩 (Emotion-on-a-chip, EOC) : 인간 감성측정을 위한 바이오칩기술의 진화", 감성과학, 14(1), pp.157~164 (2011), 한국감성과학회
  6. Lee, H. J, "Biosensing using split-ring resonators at microwave regime", Applied Physics Letters, 92(25), pp.0~0 (2008), American Institute of Physics Inc.
  7. Lee, H. J, "DNA sensing using split-ring resonator alone at microwave regime", JOURNAL OF APPLIED PHYSICS, 108(1), pp.014908~014908 (2010), American Institute of Physics
  8. Lee, J. H, "Immunoassay of prostate-specific antigen (PSA) using resonant frequency shift of piezoelectric nanomechanical microcantilever", Biosensors and Bioelectronics, 20(10), pp.2157~2162 (2005)
  9. Lee, J. M, "Direct immobilization of protein G variants with various numbers of cysteine residues on a gold surface", ANALYTICAL CHEMISTRY, 79(7), pp.2680~2687 (2007), AMER CHEMICAL SOC
  10. Leung, W, "One-step quantitative cortisol dipstick with proportional reading", Journal of Immunological Methods, 281(1), pp.190~118 (2003)
  11. Lindley, S. E, "Basal and Dexamethasone Suppressed Salivary Cortisol Concentrations in a Community Sample of Patients with Posttraumatic Stress Disorder", Biological Psychiatry, 55(9), pp.940~945 (2004)
  12. Oka, K, "Liquid Chromatography and Radloimmunoassay Compared for Determination of Cortisol and Corticosterone in Plasma after a Dexamethasone Suppression Test", Clinical Chemistry, 33(9), pp.1639~1642 (1987)
  13. Stevens, R. C, "Detection of Cortisol in Saliva with a Flow-Filtered, Portable Surface Plasmon Resonance Biosensor System", Chemistry, 80(17), pp.6747~6751 (2008)
  14. Zhang, L, "A strategy for the development of biomarker tests for PTSD", Medical Hypotheses, 73(3), pp.404~409 (2009)

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