수영과 저출력 레이저 치료가 류마티스 관절염 흰쥐의 혈청 인터루킨-6 농도에 미치는 영향
The Effects of Swimming and Low Power Laser on the Concentration of Interleukin-6 for Rheumatoid Arthritic Rats
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This study was designed to determine the effects of swimming and low power laser on rheumatoid arthritis in Sprague-Dawley rats. Rheumatoid arthritis was induced in 36 rats among 48 Sprague-Dawley rats by the subcutaneous injection of .05 ㎖ Freund's Complete Adjuvant into the right hind paw and .05 ㎖ Freund's Complete Adjuvant into the right hind knee joint capsule. A second injection was performed by the same method using .1 ㎖ Freund's Complete Adjuvant per a rat. Arthritic rats were divided into 8 groups: each 1 week and 2 weeks of arthritic swimming, arthritic laser, arthritic case control and normal group. In this study, several experimental tests were performed to determine the concentration of Interleukin-6, the space of the knee joint and the thickness of the hind paw. The concentration of Interleukin-6 and hind paw thickness decreased in the swimming group and laser group as compared to the control group. The space of the knee joint increased significantly after the swimming exercise. Swimming and low power laser therapy positively affect rheumatoid arthritis in rats affect by decreasing the concentration of Interleukin-6 and hind paw thickness, and increasing the space of the knee joint.
Abstract
This study was designed to determine the effects of swimming and low power laser on rheumatoid arthritis in Sprague-Dawley rats. Rheumatoid arthritis was induced in 36 rats among 48 Sprague-Dawley rats by the subcutaneous injection of .05 ㎖ Freund's Complete Adjuvant into the right hind paw and .05 ㎖ Freund's Complete Adjuvant into the right hind knee joint capsule. A second injection was performed by the same method using .1 ㎖ Freund's Complete Adjuvant per a rat. Arthritic rats were divided into 8 groups: each 1 week and 2 weeks of arthritic swimming, arthritic laser, arthritic case control and normal group. In this study, several experimental tests were performed to determine the concentration of Interleukin-6, the space of the knee joint and the thickness of the hind paw. The concentration of Interleukin-6 and hind paw thickness decreased in the swimming group and laser group as compared to the control group. The space of the knee joint increased significantly after the swimming exercise. Swimming and low power laser therapy positively affect rheumatoid arthritis in rats affect by decreasing the concentration of Interleukin-6 and hind paw thickness, and increasing the space of the knee joint.
참고문헌 (31)
- 김세종, "고려의학", pp.219~ (1994)
- 김재영, "흰쥐의 화농성 슬관절염 치유에 He-Ne IR레이저 처치의 효과", 대한의생명과학회지, 6(3), pp.223~228 (2000)
- 김영경, "수영이 척수손상을 입은 흰쥐의 운동기능 회복에 미치는 영향", 석사, pp.2001
- 박시복, "류마티스 관절염의 재활치료", 한양의대학술지, 18(1), pp.33~42 (1998)
- 송인광, "전갈약침이 adjuvant 유발 흰쥐의 관절활액막내 cytokine과 prostaglandin E2에 미치는 영향", 대한침구학회지, 19(2), pp.177~188 (2002), 대한침구학회
- 이동진, "Adjuvant로 유발된 관절염의 흰 쥐에서 초음파의 임상반응", 한국전문물리치료학회지, 10(2), pp.45~59 (2003), 한국전문물리치료학회
- 조성도, "류마토이드 관절염 환자에서 Interleukin-6 측정의 임상적 의의", 대한정형외과학회지, 34(2), pp.327~331 (1999)
- Andreakos ET, "Cytokines and anti-cytokine biologicals in autoimmunity: Present and future", Cytokine Growth Factor Rev, 13(4-5), pp.299~313 (2002)
- Bartels EM, "Danneskiold-Samsoe B. Pool exercise therapy of rheumatoid arthritis", Ugeskr Laeger, 163(40), pp.5507~5513 (2001)
- Bilberg A, "Moderately intensive exercise in a temperate pool for patients with rheumatoid arthritis: A randomized controlled study", Rheumatology Oxford, 44(4), pp.502~508 (2005)
- Brosseau L, "Low level laser therapy (Classes I, II and III) for treating rheumatoid arthritis", Cochrane Database Syst Rev, 19(4), pp.CD002049~ (2005)
- Campana VR, "Laser therapy on arthritis induced by urate crystals", Photomed Laser Surg, 22(6), pp.499~503 (2004)
- Castano AP, "Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time", Lasers Surg Med, 39(6), pp.543~550 (2007)
- Chang YH, "Incorporation of quantitative measurements of humoral and cellular immune response", J Pharmacol Exp Ther, 201(1), pp.1~7 (1977)
- Choy E, "Clinical experience with inhibition of interleukin-6", Rheum Dis Clin North Am, 30(2), pp.405~415 (2004)
- Christodoulou C, "Joint inflammation and cytokine inhibition in rheumatoid arthritis", Clin Exp Med, 6(1), pp.13~19 (2006)
- Cochrane T, "Randomised controlled trial of the cost-effectiveness of water-based therapy for lower limb osteoarthritis", Health Technol Assess, 9(31), pp.1~114 (2005)
- Cutolo M, "Serum cytokines and steroidal hormones in polymyalgic rheumatica and elderly-onset rheumatoid arthritis", Ann Rheum Dis, 65(11), pp.1438~1443 (2006)
- Hall J, "A randomized and controlled trial of hydrotherapy in rheumatoid arthritis", Arthritis Care Res, 9(3), pp.206~215 (1996)
- Hansen HJ, "Low power laser biostimulation of chronic oro-facial pain. A double-blind placebo controlled cross-over study in 40 patients", Pain, 43(2), pp.169~179 (1990)
- Kana JS, "Effect of low-power density laser radiation on healing of open skin wounds in rats", Arch Surg, 116(3), pp.293~296 (1981)
- Klareskog L, "What can we learn about rheumatoid arthritis from animal models?", Springer Semin Immunopathol, 11(3), pp.315~333 (1989)
- Liu SH, "Increased monocyte chemoattractant protein-1 in knee joints of rats with adjuvant -induced arthritis: In vivo microdialysis", J Rheumatol, 32(11), pp.2205~2211 (2005)
- Luo H, "Effect of bee venom on adjuvant induced arthritis in rats", Zhong Nan Da Xue Xue Bao Yi Xue Ban, 31(6), pp.948~951 (2006)
- Nishimoto N, "Inhibition of IL-6 for the treatment of inflammatory disease", Curr Opin Pharmacol, 4(4), pp.386~391 (2004)
- Schorlemmer HU, "Immunosupressive activity of 15-deoxyspergualin (15-DOS) on various models of rheumatoid arthritis", Drugs Exp Clin Res, 17(10-11), pp.471~484 (1991)
- Trentham DE, "Autoimmunity to type Ⅱ collagen an experimental model of arthritis", J Exp Med, 146(3), pp.857~868 (1977)
- Vermeirsch H, "Evaluation of pain behavior and bone destruction in two arthritic models in guinea pig and rat", Pharmacol Biochem Behav, 87(3), pp.349~359 (2007)
- Whitehouse MW, "Freund's adjuvants: Relationship of arthritogenicity and adjuvanticity in rats to vehicle composition", Immunology, 27(2), pp.311~330 (1974)
- Yu Y, "In vivo evaluation of early disease progression by X-ray phase-contrast imaging in the adjuvant-induced arthritic rat", Skeletal Radiol, 35(3), pp.156~164 (2006)
- Yu YC, "Two variables that can be used as pain indices in experimental animal models of arthritis", J Neurosci Methods, 115(1), pp.107~113 (2002)