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문제적 과잉 성 행동자의 휴지기 상태 시 집행 통제 회로의 기능적 연결성 변화

Altered functional connectivity of the executive control network during resting state among males with problematic hypersexual behavior

석지우
한국감성과학회 (The Korean Society For Emotion & Sensibility)|2019.03|감성과학 (Science of Emotion & Sensibility)|제22권 제1호|pp. 35-44|DOI https://doi.org/10.14695/KJSOS.2018.22.1.35

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참고문헌

키워드

functional connectivity기능적 연결성functional magnetic resonance imaging문제적 과잉 성 행동자휴지기 자기공명영상집행 통제 회로상/중 전두회problematic hypersexual behaviorexecutive control networksuperior/middle frontal gyrus
주제분류감성과학

초록

문제적 과잉 성 행동은 성 충동과 각성을 통제하지 못하는 것과 관련이 있으며, 억제 기능을 담당하는 뇌 영역의 구조적, 기능적 변화와 관련이 있음이 밝혀졌다. 그러나 아직까지 문제적 과잉 성 행동의 휴지기 상태 시 뇌의 기능적 연결성에 관한 연구는 거의 없다. 따라서 본 연구에서는 자기공명영상장치를 사용하여 휴지기 상태 시 문제적 과잉 성 행동자의 집행 통제 회로(RECN, LECN)의 기능적 연결성의 결함을 규명하고자 하였다. 이를 위해 17명의 문제적 과잉 성 행동자와 인구통계학적 특성이 유사한 20명의 정상대조군을 대상으로 휴지기 상태 시 자기공명영상데이터가 획득하였다. 실행기능 제어 회로(LECN, RECN)와 관련된 영역을 관심 뇌 영역으로 선정하였으며, 이들 영역간 시계열 신호와의 상관계수를 기능 연결성 정도로 가정하고 집단 간 비교 검증을 하였다. 그 결과, 정상대조군과 문제적 과잉 성행동군의 집행 통제회로의 기능적 연결 강도에 유의한 차이가 나타났다. 즉, 정상대조군에 비해 문제적 과잉 성행동군은 상/중전두회와 미상핵, 상/중전두회와 두정회의 기능적 연결성이 저하된 것으로 나타났다. 또한, 이 영역간 기능적 연결강도는 과잉 성 행동 지수와 부적상관이 있는 것으로 나타났다. 본 연구 결과는 문제적 과잉 성행동자들이 성 충동과 각성을 제어하지 못하는 것이 집행 통제회로의 기능적 연결성 저하와 관련이 있음을 시사한다.

Abstract

Individuals with Problematic hypersexual behavior (PHB) has shown the in the inability to control sexual impulses and arousal. The previous studies identified these characteristics are related to the structural and functional changes of the brain region responsible for inhibitory functions. However, very little research has been done on functional connectivities among the brain areas during the resting state in Individuals with Problematic hypersexual behavior. Therefore, the purpose of this study is to identify the deficit of the functional connectivity in the executive control network during resting state using functional magnetic resonance imaging devices among Individuals with Problematic hypersexual behavior. For this study, magnetic resonance imaging data were obtained for 16 individuals with PHB and 19 normal controls with similar demographic characteristics. The areas related to the executive control network (LECN, RECN) were selected as the region of interest, and the correlation coefficient with time series signals between these areas was measured to identify the functional connectivity, and between groups analysis was used. The results showed a significant difference in the functional connectivity strength of executive control network between two groups. In other words, there are the decreased functional connectivities between superior/middle frontal gyrus and caudate, and between superior/middle frontal gyrus and superior parietal gyrus/angular gyrus in the individuals with PHB. In addition, these functional connectivities were related to the severity of hypersexual behavior. The results of this study suggest that the inability to control sexual impulses and arousal in individuals with PHB might be related to the reduced functional connectivity of executive control circuits.

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