흰쥐의 肝損傷에 대한 加味愈肝湯의 肝 保護效果
Protective Effects of Gami Yugan-tang on Liver Damage in Rats
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In order to investigate the protective effects of Gami Yugan-tang on liver damage in rats induced by CCl4 and d-galactosamine, the serum transaminase(ALT & AST), alkaline phosphatase(ALP), lactic dehydrogenase(LDH), superoxide dismutase(SOD), catalase, glutathione S-transferase(GST), glutathione peroxidase(GPX) for enzyme activities, and lipid peroxidation were measured. All animals were divided into 4 groups: normal group (untreated), control group (treated with 0.9% saline solution), sample Ⅰ group (treated with 740㎎/㎏ Gami Yugan-tang), and sample Ⅱ group (treated with 1,480㎎/㎏ Gami Yugan-tang).The results were as follows :1. The results of liver damage in rats induced by CCl4 : The protective effects of ALT were displayed in sample Ⅰ and sample Ⅱ, and AST, ALP, LDH, SOD, catalase, GST, GPX, and lipid peroxidation were noted in sample Ⅱ group. It showed slight necrosis of hepatic cell and pathologic changes, for example, inflammatory cells infiltration were improved in sample Ⅱ group compared to the control group. 2. The results of liver damage in rats induced by d-galactosamine : The inhibitory effects of AST, ALT, LDH, and ALP activities were noted in both sample Ⅰ and sample Ⅱ groups. The findings from this experiment suggests that Gami Yugan-tang has protective effects against liver damage in rats induced by CCl4 and d-galactosamine.
Abstract
In order to investigate the protective effects of Gami Yugan-tang on liver damage in rats induced by CCl4 and d-galactosamine, the serum transaminase(ALT & AST), alkaline phosphatase(ALP), lactic dehydrogenase(LDH), superoxide dismutase(SOD), catalase, glutathione S-transferase(GST), glutathione peroxidase(GPX) for enzyme activities, and lipid peroxidation were measured. All animals were divided into 4 groups: normal group (untreated), control group (treated with 0.9% saline solution), sample Ⅰ group (treated with 740㎎/㎏ Gami Yugan-tang), and sample Ⅱ group (treated with 1,480㎎/㎏ Gami Yugan-tang).The results were as follows :1. The results of liver damage in rats induced by CCl4 : The protective effects of ALT were displayed in sample Ⅰ and sample Ⅱ, and AST, ALP, LDH, SOD, catalase, GST, GPX, and lipid peroxidation were noted in sample Ⅱ group. It showed slight necrosis of hepatic cell and pathologic changes, for example, inflammatory cells infiltration were improved in sample Ⅱ group compared to the control group. 2. The results of liver damage in rats induced by d-galactosamine : The inhibitory effects of AST, ALT, LDH, and ALP activities were noted in both sample Ⅰ and sample Ⅱ groups. The findings from this experiment suggests that Gami Yugan-tang has protective effects against liver damage in rats induced by CCl4 and d-galactosamine.
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