자원지황탕을 활용한 당뇨병 혈당 관리 치료 76례에 대한 관찰 연구
Management of Blood Glucose in Diabetes Mellitus Using Modified Jawonjihwang-tang: A Retrospective Case Series of 76 Patients
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: The purpose of this study was to evaluate the effectiveness of the management of blood glucose in diabetes mellitus using modified Jawonjihwang-tang in a Korean medical clinic, retrospectively. Methods: From 2006 to 2018, 150 patients diagnosed with diabetes who visited a Korean medical clinic were treated with Korean medicine. Then, 81 of them were prescribed Jawonjihwang-tang. Five cases who changed the formula during the procedure were excluded; therefore, 76 cases were finally selected. Their therapeutic effects were evaluated by the variance in glycated hemoglobin (HbA1c). Results: After administration of Jawonjihwang-tang, most patients exhibited a decreased level of HbA1c, and 24 patients had normalized the level of HbA1c. The HbA1c level of all patients decreased from 9.1±2.2 to 7.8±2.2 significantly (p<0.001). Conclusions: It is concluded that Jawonjihwang-tang may control blood glucose in diabetes patients. However, more prospective randomized clinical trials are warranted to verify this conclusion.
Abstract
Objectives: The purpose of this study was to evaluate the effectiveness of the management of blood glucose in diabetes mellitus using modified Jawonjihwang-tang in a Korean medical clinic, retrospectively. Methods: From 2006 to 2018, 150 patients diagnosed with diabetes who visited a Korean medical clinic were treated with Korean medicine. Then, 81 of them were prescribed Jawonjihwang-tang. Five cases who changed the formula during the procedure were excluded; therefore, 76 cases were finally selected. Their therapeutic effects were evaluated by the variance in glycated hemoglobin (HbA1c). Results: After administration of Jawonjihwang-tang, most patients exhibited a decreased level of HbA1c, and 24 patients had normalized the level of HbA1c. The HbA1c level of all patients decreased from 9.1±2.2 to 7.8±2.2 significantly (p<0.001). Conclusions: It is concluded that Jawonjihwang-tang may control blood glucose in diabetes patients. However, more prospective randomized clinical trials are warranted to verify this conclusion.
참고문헌 (24)
- "Diabetes fact sheet in Korea 2018" (2018)[URL]
- 통계청 인구동향과, "Cause-of-death statistics in 2016 in the Republic of Korea", 대한의사협회지, 61(9), pp.573~584 (2018), 대한의사협회[DOI]
- 김도형, "당뇨병의 한의학적 치료에 대한 최신 연구 동향 - 2008년부터 2013년까지 국내 학술논문을 중심으로 -", 대한한방내과학회지, 34(3), pp.240~255 (2013), 대한한방내과학회
- Gallagher EJ, "Review of hemoglobin A(1c)in the management of diabetes", J Diabetes, 1(1), pp.9~17 (2009)
- Diabetes guideline committee, "Treatment guideline for diabetes 2019", Korean diabetes association, 1~86 (2019)
- UKPDS Group, "UK prospective diabetes study 7:response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients", Metabolism, 39(9), pp.905~912 (1990)
- 박태선, "특집", 당뇨병 관리의 일반적 원칙, 2008, pp.51(9), 806~812[DOI]
- 전자영, "당뇨병환자에서 혈당조절의 목표", 대한의사협회지, 60(11), pp.889~892 (2017), 대한의사협회[DOI]
- Murata GH, "Intensified blood glucose monitoring improves glycemic control in stable, insulin-treated veterans with type 2 diabetes : the diabetes outcomes in veterans study(DOVES)", Diabetes care, 26(6), pp.1759~1822 (2003)
- Duckworth WC, "The duration of diabetes affects the response to intensive glucose control in type 2 subjects : the VA diabetes trial", J Diabetes Complications, 25(6), pp.355~361 (2011)
- Kim GY, "Short-term Glycemic control and the related factor in association with compliance in diabetic patient", Journal of Preventive Medicine and Public Health, 33(3), pp.349~363 (2000)
- 김상아, "우리나라 당뇨병의 유병률과 관리 상태", 대한내과학회지, 68(1), pp.10~17 (2005), 대한내과학회
- Cho NH, "Prevalence of diabetes and management status in Korean population", Korean J Med, 68(1), pp.1~3 (2005)
- Pu R, "Liuwei dihuang pills(六味地黄丸)enhance the effect of western medicine in treating type 2 diabetes : a meta-analysis of randomized controlled trials", Chin J Integr Med, 19(10), pp.783~874 (2013)
- Lin L, "Therapeutic efficacy evaluation by a randomized controlled clinical research on traditional Chinese medical formulas, with herb modification according to syndrome differentiation in the treatment of 200 type 2 diabetic patients", Journal of Medical Research, 42(2), pp.102~107 (2013)
- Xie W, "Traditional Chinese medicines in treatment of patients with type 2 diabetes mellitus", Evid Based Complement Alternat Med, 2011, pp.726723~ (2011)
- 박성하, "最近 糖尿病에 있어서 中醫의 辨證變化에 관한 硏究 - 2003~2010년 발표된 中醫論文을 중심으로 -", 동의생리병리학회지, 25(2), pp.176~184 (2011), 한의병리학회
- Kim YH, "Cheongganguigam", pp.339~ (2001), Seongbosa
- Mugabo Y, "Identification of a mammalian glycerol-3-phosphate phosphatase : Role in metabolism and signaling in pancreatic beta-cells and hepatocytes", Proc Natl Acad Sci USA, 113(4), pp.430~439 (2016)
- Zhao S, "Alpha", beta-hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes, 2016, pp.14(12), 2872~2888
- Ying B, "Catalpol in diabetes and its complications : a review of pharmacology, pharmacokinetics, and safety", Molecules, 24(18), pp.3302~ (2019)
- 최경순, "산약 추출물의 리포좀 처리가 Streptozotocin으로 유발된 당뇨 마우스의 혈당 강하 효과와 혈장 인슐린 및 지질에 미치는 영향", 한국식품영양학회지, 26(2), pp.310~317 (2013), 한국식품영양학회[DOI]
- 김옥경, "산수유 추출물이 Streptozotocin으로 유발된 흰쥐의 항당뇨 및 항산화 작용에 미치는 효과", 한국응용과학기술학회지, 22(2), pp.157~167 (2005), 한국응용과학기술학회
- Huang YQ, "Long-term clinical effect of Tangyiping granules on patients with impaired glucose tolerance", Chin J Integr Med, 22(9), pp.653~659 (2016)
