본문 바로가기
KERD
논문KCI 등재

기능성 소화불량에서 초음파 위배출능 측정간격에 대한 임상연구

Clinical Study on Measurement Intervals in the Ultrasonographic Gastric Emptying Test for Functional Dyspepsia

고석재|박재우|전혜진|김금지
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2020.12|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제41권 제6호|pp. 1030-1051|DOI https://doi.org/10.22246/jikm.2020.41.6.1030

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

abdominal examinationquestionnaireultrasonographyfunctional dyspepsiagastric emptying
주제분류한의학

초록

Objective: This study investigated the measurement interval in the ultrasonographic gastric emptying test for patients with functional dyspepsia (FD) and the correlation between gastric emptying and the findings of various questionnaires. Methods: In total, 119 patients (59 patients with FD and 60 healthy controls) were recruited from July 2018 to June 2020. Gastric volume (GV) and gastric emptying half-time (T1/2) were measured by ultrasonography at fasting and again at 0, 5, 10, 15, 30, 45, 60, 90, and 120 min after meals (apple juice, 500 mL, 224 kcal), and the average half-time (average T1/2) was calculated. Questionnaires on food retention (FRQ), phlegm pattern e (PPQ), cold and heat (CHQ), deficiency and excess (DEQ), and spleen-qi deficiency (SQDQ), stomach qi deficiency pattern (SSDQ), visual analogue scale (VAS), and Nepean dyspepsia index-Korean version (NDI-K) were completed by all participants. The differences in GV and T1/2 were analyzed in participants whose maximal GV occurred at 0 min versus after 0 min. The correlation of the average T1/2 with the questionnaire scores was also analyzed after excluding erroneous data. Results: Patients with FD who took a certain amount of time to reach maximal GV after meals had a greater gastric volume up to about 30 minutes after meals, and the PPQ, DEQ, and NDI-K scores, especially for upper gastrointestinal symptoms and general weakness-related symptoms, showed statistically significant correlations with average T1/2. Conclusions: Ultrasonography can be a quantitative evaluation tool for FD. However, further studies on measurement methods based on FD physiopathology are required.

Abstract

Objective: This study investigated the measurement interval in the ultrasonographic gastric emptying test for patients with functional dyspepsia (FD) and the correlation between gastric emptying and the findings of various questionnaires. Methods: In total, 119 patients (59 patients with FD and 60 healthy controls) were recruited from July 2018 to June 2020. Gastric volume (GV) and gastric emptying half-time (T1/2) were measured by ultrasonography at fasting and again at 0, 5, 10, 15, 30, 45, 60, 90, and 120 min after meals (apple juice, 500 mL, 224 kcal), and the average half-time (average T1/2) was calculated. Questionnaires on food retention (FRQ), phlegm pattern e (PPQ), cold and heat (CHQ), deficiency and excess (DEQ), and spleen-qi deficiency (SQDQ), stomach qi deficiency pattern (SSDQ), visual analogue scale (VAS), and Nepean dyspepsia index-Korean version (NDI-K) were completed by all participants. The differences in GV and T1/2 were analyzed in participants whose maximal GV occurred at 0 min versus after 0 min. The correlation of the average T1/2 with the questionnaire scores was also analyzed after excluding erroneous data. Results: Patients with FD who took a certain amount of time to reach maximal GV after meals had a greater gastric volume up to about 30 minutes after meals, and the PPQ, DEQ, and NDI-K scores, especially for upper gastrointestinal symptoms and general weakness-related symptoms, showed statistically significant correlations with average T1/2. Conclusions: Ultrasonography can be a quantitative evaluation tool for FD. However, further studies on measurement methods based on FD physiopathology are required.

참고문헌 (33)

  1. Tack J, "Functional Gastroduodenal Disorders", Gastroenterology, 130(5), pp.1466~1479 (2006)
  2. Brun R, "Functional Dyspepsia", Therapeutic Advances in Gastroenterology, 3(3), pp.145~164 (2010)
  3. Mahadeva S, "Epidemiology of Functional Dyspepsia : A Global Perspective", World Journal of Gastroenterology, 12(17), pp.2661~2666 (2006)
  4. 박재명, "Functional Gastrointestinal Disorders Diagnosed by Rome III Questionnaire in Korea", Journal of Neurogastroenterology and Motility (JNM), 17(3), pp.279~286 (2011), 대한소화기 기능성질환∙운동학회
  5. Vanheel H, "Changes in Gastrointestinal Tract Function and Structure in Functional Dyspepsia", Nat Rev Gastroenterol Hepatol, 10(3), pp.142~149 (2013)
  6. 조수호, "초음파 위배출 측정과 한의설문 간의 상관성 분석", 대한한방내과학회지, 39(4), pp.570~591 (2018), 대한한방내과학회
  7. Mechanisms, Physiology, and Recent Research Progress of Gastric Emptying, "Liu W", Critical Reviews in Food Science and Nutrition, 1~14 (2020)
  8. Haruma K, "Real-time Assessment of Gastroduodenal Motility by Ultrasonography", Digestion, 77(SUPPL. 1), pp.48~51 (2008)
  9. Committee of Digestive Diesease, "National Korean Medicine College", pp.13~19 (2008), Koonja
  10. 백승환, "기능성 소화불량 환자에서 초음파로 측정한 위 배출능과 脾氣虛證 간의 상관성 분석", 대한한방내과학회지, 36(4), pp.527~546 (2015), 대한한방내과학회
  11. 남성욱, "기능성소화불량에서 胃氣虛證과 복부초음파로 측정한 위 배출능과의 상관성 분석", 대한한방내과학회지, 39(3), pp.405~425 (2018), 대한한방내과학회
  12. Van De Putte P, "Ultrasound Assessment of Gastric Content and Volume", Br J Anaesth, 113(1), pp.12~22 (2014)
  13. Lee HW, "Ultrasonographic Gastric Emptying in Patients with Functional Dyspepsia", Korean J Gastroenterol, 31(1), pp.1~8 (1998)
  14. Park YJ, "Development of a Valid and Reliable Food Retention Questionnaire", Eur J Integr Med, 5(5), pp.432~437 (2013)
  15. Park YJ, "Development of a Valid and Reliable Phlegm Pattern Questionnaire", J Altern Complement Med, 17(9), pp.851~858 (2011)
  16. 유현희, "한열 변증 설문지 개발에 관한 연구", 동의생리병리학회지, 22(6), pp.1410~1415 (2008), 한의병리학회
  17. 여민경, "건강 증진을 위한 평소 증상 기반의 한열변증 설문지 개발 – 신뢰도를 중심으로", 동의생리병리학회지, 30(2), pp.116~123 (2016), 한의병리학회[DOI]
  18. 최산호, "중풍 후 우울증의 변증안에 대한 전문가 델파이 조사", 동의생리병리학회지, 26(3), pp.367~375 (2012), 한의병리학회[DOI]
  19. 오혜원, "脾氣虛證 진단평가도구 개발 연구", 대한한의학회지, 35(1), pp.157~170 (2014), 대한한의학회
  20. Lee JH, "Development and Validation of a New Pattern Identification Scale for Stomach Qi Deficiency", Eur J Integr Med, 17, pp.56~63 (2018)
  21. Talley NJ, "Development of a new dyspepsia impact scale : The Nepean Dyspepsia Index", Aliment Pharmacol Ther, 13(2), pp.225~235 (1999)
  22. Lee SY, "Validation of the Nepean Dyspepsia Index-Korean version", Kor J Neurogastroenterol Motil, 9, pp.48~ (2003)
  23. Tack J, "Role of Impaired Gastric Accommodation to a Meal in Functional Dyspepsia", Gastroenterology, 115(6), pp.1346~1352 (1998)
  24. Haruki Asano, "Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia", Journal of Neurogastroenterology and Motility (JNM), 23(3), pp.392~399 (2017), 대한소화기 기능성질환∙운동학회[DOI]
  25. Stanghellini V, "Gastroduodenal Disorders", Gastroenterology, 150(6), pp.1380~1392 (2016)
  26. Tack J, "Gastric motor disorders", Best Pract Res Clin Gastroenterol, 21(4), pp.633~644 (2007)
  27. Kindt S, "Impaired Gastric Accommodation and its Role in Dyspepsia", Gut, 55(12), pp.1685~1691 (2006)
  28. Miwa H, "Current understanding of pathogenesis of functional dyspepsia", J Gastroenterol Hepatol, 26(SUPPL.3), pp.53~60 (2011)
  29. Gilja OH, "Impaired Accommodation of Proximal Stomach to a Meal in Functional Dyspepsia", Dig Dis Sci, 41(4), pp.689~696 (1996)
  30. Steinsvik EK, "The Ultrasound Meal Accommodation Test in 509 Patients with Functional Gastrointestinal Disorders", Scand J Gastroenterol, 51(7), pp.788~794 (2016)
  31. Kusunoki H, "Efficacy of Mosapride Citrate in Proximal Gastric Accommodation and Gastrointestinal Motility in Healthy Volunteers : A Double-Blind Placebo-Controlled Ultrasonographic Study", J Gastroenterol, 45(12), pp.1228~1234 (2010)
  32. Hong Sub Lee, "Can Ultrasonographic Measurements of Gastric Motility Identify Pathophysiological Abnormalities of Functional Dyspepsia and Irritable Bowel Syndrome?", Journal of Neurogastroenterology and Motility (JNM), 26(1), pp.1~3 (2020), 대한소화기 기능성질환∙운동학회[DOI]
  33. 백소영, "기능성소화불량에 대한 담음 변증설문지 개발과 신뢰도 및 타당도 검정", 대한한방내과학회지, 41(4), pp.563~582 (2020), 대한한방내과학회[DOI]

관련 논문AI추천

초음파 위배출 측정과 한의설문 간의 상관성 분석고석재, 김진성, 박재우, 이재홍, 조수호대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제4호기능성 소화불량 환자에서 초음파로 측정한 위 배출능과 脾氣虛證 간의 상관성 분석김진성, 백승환대한한방내과학회 · 대한한방내과학회지2015 · 제36권 제4호기능성소화불량에서 胃氣虛證과 복부초음파로 측정한 위 배출능과의 상관성 분석김진성, 남성욱, 박재우대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제3호기능성 소화불량 환자의 한방치료 전후의 주관적 평가지표와 Electrogastrography Parameters를 이용한 객관적 지표의 변화 관찰김진성, 류봉하, 한가진대한한방내과학회 · 대한한방내과학회지2011 · 제32권 제4호식적으로 진단된 기능성소화불량 환자의 임상적 특성금창열, 김진성, 이하늘, 이현진, 정해인, 조윤재, 하나연, 한아람대한한방내과학회 · 대한한방내과학회지2021 · 제42권 제6호기능성 소화불량증 환자의 위장관 부교감 신경, 위 유문부의 기능 및 임상양상에 대한 조사 (한방병원 내원 환자를 중심으로)윤상협, 홍인아대한한방내과학회 · 대한한방내과학회지2008 · 제29권 제3호

이 간행물의 다른 논문 (30건)

한약복용이 간기능에 미치는 영향 : 국내 문헌에 대한 체계적 고찰제유란, 박상은, 김경림, 하다정pp. 933-946파킨슨병 환자의 통증에 대한 한의치료의 효과 : 후향적 연구김서영, 박성욱, 권승원, 정혜선, 임태빈, 정우상, 박정미, 조승연, 문상관, 진철, 고창남, 김하리pp. 947-958한약 임상시험의 특성 : 질병관리본부 임상연구정보서비스(CRIS)를 중심으로전선우, 조희근, 정창운pp. 959-966오가피청혈플러스가 NF-κB 및 MAPKs 신호전달체계와 혈관부착인자 등에 미치는 영향배지은, 유호룡, 김윤식, 최규철, 설인찬, 이지원pp. 967-983임상한의학 실시간 비대면교육의 평가를 위한 설문조사 연구양승보pp. 984-992
원문 보기