黃連阿膠湯이 Free Cholesterol에 의한 혈관내피세포 손상에 미치는 영향
The Effect of Hwangryunagyotang water extract on Endothelial cells by Free cholesterol
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Abstract
An Hwangryunagyotang is supposed to have significant effects on some sorts of cardiovascular diseases like atherosclerosis. Especially in this study, ACAT inhibitor is put in LDLR -/- mice to derive free cholesterol from it. This is to examine how effective the Hwangryunagyotang on its protecting and recovering function with endothelial cells which is damaged by free cholesterol through experimental ways. And the result is like below.The Hwangryunagyotang has suppressed the crystallization of reactive oxygen species in macrophages and the numbers of free cholesterol crystal plate structured and reduced fragmentation of nucleus in ECV 304 cell strain by ACAT inhibitor significantly. And also it shows that the Hwangryunagyotang suppress the necrosis of tissue in LDLR -/- mice's (treated with ACAT inhibitor) inflammatory portion which is adjacent to aortic root, proximal aorta and carotid artery by immunohistochemistry and fluorescence microscopy.As a whole, the Hwangryunagyotang suppress the necrosis of endothelial cells and especially it's effcetive for the necrosis of para-myocardial tissues by free cholesterol. With this result, I suggest that the Hwangryunagyotang might have protective and recovery effects on atherosclerosis, so we need to carry on this study henceforth clinically and experimentally as well.
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