중풍환자에서 대사증후군과 적혈구변형능의 관련성
The Relationship between Metabolic Syndrome and the Erythrocyte Deformability in Small Vessel Disease Stroke Patients
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives : The aim of this study was to assess the relationship between Metabolic Syndrome and Erythrocyte Deformability in acute stroke patients. Methods : Among 88 of the recruited patients, 52 were diagnosed as Metabolic syndrome. We assessed their general characteristics, risk factors. We compared the assessed variables between Metabolic syndrome and control group. We analyzed the relationship between Metabolic Syndrome and erythrocyte deformability. we analyzed relationship between cardiovascular risk factors and erythrocyte deformability. Results : On the General Characteristics waist and hip circumference, waist/hip ratio were higher in Metabolic Syndrome Group. Metabolic Syndrome Group diagnosed HTN, DM, hyperlipidemia more than control group. In blood test metabolic syndrome group showed higher Triglyceride, Total Lipid, Fasting blood sugar, 2 hours postprandial plasma glucose level and lower HDL than control group. There were more patients diagnosed Dampness-Phlegm in metabolic syndrome group. There were more patients showed lower erythrocyte deformability in metabolic syndrome group. The Plasma homocysteine level was negatively correlated with erythrocyte deformability. Conclusion : The results reconfirmed that the risk factors are more in Metabolic syndrome group. The results indicated that the metabolic syndrome lead to a lower erythrocyte deformability in small vessel disease stroke patients. The Plasma homocysteine level was negatively correlated with erythrocyte deformability
Abstract
Objectives : The aim of this study was to assess the relationship between Metabolic Syndrome and Erythrocyte Deformability in acute stroke patients. Methods : Among 88 of the recruited patients, 52 were diagnosed as Metabolic syndrome. We assessed their general characteristics, risk factors. We compared the assessed variables between Metabolic syndrome and control group. We analyzed the relationship between Metabolic Syndrome and erythrocyte deformability. we analyzed relationship between cardiovascular risk factors and erythrocyte deformability. Results : On the General Characteristics waist and hip circumference, waist/hip ratio were higher in Metabolic Syndrome Group. Metabolic Syndrome Group diagnosed HTN, DM, hyperlipidemia more than control group. In blood test metabolic syndrome group showed higher Triglyceride, Total Lipid, Fasting blood sugar, 2 hours postprandial plasma glucose level and lower HDL than control group. There were more patients diagnosed Dampness-Phlegm in metabolic syndrome group. There were more patients showed lower erythrocyte deformability in metabolic syndrome group. The Plasma homocysteine level was negatively correlated with erythrocyte deformability. Conclusion : The results reconfirmed that the risk factors are more in Metabolic syndrome group. The results indicated that the metabolic syndrome lead to a lower erythrocyte deformability in small vessel disease stroke patients. The Plasma homocysteine level was negatively correlated with erythrocyte deformability
참고문헌 (30)
- Adams HP Jr, "Guidelines for the early management of adults with ischemic stroke", Circulation, 115(20), pp.478~534 (2007)
- 박종호, "허혈성 뇌졸중 환자에서 대사증후군과 호모시스테인의 관계", 대한신경과학회지, 23(1), pp.9~14 (2005), 대한신경과학회
- 이성민, "허혈성 뇌졸중 아형에 따른 대사성 뇌졸중 위험인자의 역할 차이", 전남의대학술지, 42(2), pp.116~123 (2006)
- 김동현, "Ektacytometer를 이용한 tert-Butyl Hydroperoxide, Verapamil 및 Ascorbate 처리 적혈구의 혈액유변학적 변형능 측정", The Korean Journal of Laboratory Medicine, 28(5), pp.325~331 (2008), 대한진단검사의학회
- Solá, E, "Erythrocyte deformability in obesity measured by ektacytometric techniques", Clinical Hemorheology and Microcirculation, 37(3), pp.219~227 (2007)
- Aloulou I, "Hemorheological disturbances correlate with the lipid profile but not with the NCEP-ATPIII score of the metabolic syndrome", Clinical Hemorheology and Microcirculation, 35(1), pp.207~212 (2006)
- 고성규, "뇌혈관질환의 한양방적인 위험요인 규명 및 진단 표준화 연구를 위한 CRF 및 SOP 개발", 대한한의학회지, 27(1), pp.204~219 (2006), 대한한의학회
- 김용재, "대사증후군과 뇌졸중", 대한신경과학회지, 23(5), pp.585~594 (2005), 대한신경과학회
- 유선미, "대사증후군과 심혈관질환", 가정의학회지, 25(11), pp.502~506 (2005)
- Executive Summary of the Third Report of the National Cholesterol Education Program (NECP), "Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)", JAMA, 285, pp.2486~2497 (2001)
- Spence JD, "Patients with atherisclerotic vascular disease: how low should plasma homocystine levels go?", Am J Cardiovasc Drugs, 1(2), pp.85~89 (2001)
- Harold P, "Design of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)", Control Clin Trials, 18, pp.358~377 (1997)
- 윤경선, "성인 남녀에서 대사증후군과 혈장 호모시스테인과의 관계", 가정의학회지, 29(7), pp.499~505 (2008), 대한가정의학회
- Grundy SM, "Diagnosis and management of the metabolic syndrome: An American Heart Association", National Heart, Lung, and Blood Institute scientific statement, 2005, pp.112(17), 2735~2752
- WHO Western Pacific Region, "The Asia-Pacific Perspective : Redifinding obesity and its treatment" (2000), Health Communications Australia Pty Ltd
- 김유경, "방사선 조사 적혈구의 유변학적 변화", 대한수혈학회지, 18(3), pp.129~137 (2007)
- Sehyun Shin, "Singh. Rheological characteristics of erythrocytes incubated in glucose media", Clinical Hemorheology and Microcirculation, 38, pp.153~161 (2008)
- Shin S, "Validation and application of a microfluidic ektacytometer (RheoScan-D) in measuring erythrocyte deformability", Clinical Hemorheology and Microcirculation, 37, pp.319~328 (2007)
- 테라사, "증례로 배우는 동서의학", pp.48~110 (2005), 군자출판사
- Sehyun Shin, "Progressive impairment of erythrocyte deformability as indicator of microangiography in type 2 diabetes mellitus", Clinical Hemorheology and Microcirculation, 36, pp.253~261 (2007)
- 민인규, "급성기 뇌경색 환자의 생활습관과 혈장 homocysteine 농도에 관한 단면적 연구", 대한한의학회지, 30(2), pp.56~62 (2009), 대한한의학회
- Aloulou I, "The hemorheological aspects of the metabolic syndrome are a combination of separate effects of insulin resistance, hyperinsulinemia and adiposity", Clinical Hemorheology and Microcirculation, 35(1-2), pp.113~119 (2006)
- 민인규, "中風환자의 濕痰辨證과 대사증후군과의 관련성 연구", 대한한의학회지, 30(1), pp.109~119 (2009), 대한한의학회
- 한숙영, "기혈수변증에 의한 기능성 소화불량환자의 변증유형 분석", 대한한방내과학회지, 25(2), pp.224~237 (2004), 대한한방내과학회
- 신세현, "당뇨병과 바이오 유체공학", 기계저널, 47(6), pp.49~55 (2007)
- 임열리, "ATP III의 진단기준에 따른 대사증후군의 유병률과 관련위험요인 분석 -일개 대학병원 건강증진센터 수진자를 대상으로-", Korean Journal of Family Medicine, 24(2), pp.135~143 (2003), 대한가정의학회
- 이인생, "당뇨병 환자에서 적혈구 변형능에 관한 연구", 당뇨병, 17(1), pp.79~87 (1993)
- 이양규, "고혈압 환자에서의 적혈구 변형능에 관한 연구", 순환기, 24(1), pp.1~7 (1994)
- Szapary L, "Hemorheological disturbances in patients with chronic cerebrovascular disease", Clinical Hemorheology and Microcirculation, 31(1), pp.1~9 (2004)
- 김상범, "뇌경색 환자에서 고호모시스테인혈증과 C677T MTHER 유전자 다형성의 상관 관계", 대한신경과학회지, 20(4), pp.346~352 (2002), 대한신경과학회