加味玉女煎이 高血壓白鼠의 血壓 有關因子 변화에 미치는 影響
The Effect of Gamioknyeo-jeon on Spontaneously Hypertensive Rats
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Objective : This study was done to investigate the effect of Gamioknyeo-jeon (GOJ) on spontaneously hypertensive rats. Methods : Spontaneously hypertensive rats were sensitized and challenged with GOJ for 4 weeks. the experimental group was treated with 56.7mg/kg/day of GOJ orally while the control group was treated with 56.7mg/kg/day of normal saline instead. Results :1. GOJ significantly showed safety against cytotoxicity and toxicity in the liver. 2. GOJ significantly decreased the heart rate and the blood pressure in Spontaneously hypertensive rats. 3. GOJ significantly decreased the levels of aldosterone in Spontaneously hypertensive rats. 4. GOJ significantly decreased the levels of dopamine and norepinephrine in Spontaneously hypertensive rats. 5. GOJ significantly decreased the levels of potassium and chloride in Spontaneously hypertensive rats. 6. GOJ significantly decreased the levels of uric acid, BUN and creatinine in Spontaneously hypertensive rats. Conclusion : These results suggest that GOJ might be useful in treatment of hypertension.
Abstract
Objective : This study was done to investigate the effect of Gamioknyeo-jeon (GOJ) on spontaneously hypertensive rats. Methods : Spontaneously hypertensive rats were sensitized and challenged with GOJ for 4 weeks. the experimental group was treated with 56.7mg/kg/day of GOJ orally while the control group was treated with 56.7mg/kg/day of normal saline instead. Results :1. GOJ significantly showed safety against cytotoxicity and toxicity in the liver. 2. GOJ significantly decreased the heart rate and the blood pressure in Spontaneously hypertensive rats. 3. GOJ significantly decreased the levels of aldosterone in Spontaneously hypertensive rats. 4. GOJ significantly decreased the levels of dopamine and norepinephrine in Spontaneously hypertensive rats. 5. GOJ significantly decreased the levels of potassium and chloride in Spontaneously hypertensive rats. 6. GOJ significantly decreased the levels of uric acid, BUN and creatinine in Spontaneously hypertensive rats. Conclusion : These results suggest that GOJ might be useful in treatment of hypertension.
참고문헌 (18)
- 전국한의과대학심계내과학교실, "심계내과학", pp.154~ (2006), 군자출판사
- 보건복지가족부 질병관리본부, "2007 국민건강통계", 58~ (2008)
- 조명찬, "고혈압의 새로운 치료방법", 대한내과학회지, 76(4), pp.409~415 (2009), 대한내과학회
- JNC, "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure", Hypertension, 42, pp.1206~ (2003)
- 조현경, "導痰湯이 腦損傷 및 高血壓에 미치는 영향", 대한한방내과학회지, 22(4), pp.503~512 (2001)
- 유병찬, "加味鷄血藤湯이 高血壓에 미치는 影響", 대한한방내과학회지, 25(4), pp.52~64 (2004), 대한한방내과학회
- 신황수, "加味導赤散이 고혈압에 미치는 영향", 동의생리병리학회지, 18(6), pp.1710~1713 (2004), 대한동의병리학회
- 김종원, "고cholesterol 식이 자발성 고혈압 白鼠에서의 加味防風通聖散이 고혈압에 미치는 영향", 대한한방내과학회지, 27(3), pp.617~628 (2006), 대한한방내과학회
- 백경민, "加味滋陰降火湯이 SHR의 혈압에 미치는 영향", 대한한방내과학회지, 27(1), pp.1~15 (2006), 대한한방내과학회
- 조봉현, "加味四物湯이 고혈압에 미치는 영향", 동의생리병리학회지, 20(1), pp.131~137 (2006), 대한동의병리학회
- 김은혜, "天麻鉤藤飮加味方이 고혈압에 미치는 영향", 동의생리병리학회지, 21(5), pp.1176~1184 (2007), 대한동의병리학회
- 박경호, "청열도담탕이 고혈압에 미치는 영향", 동의생리병리학회지, 21(3), pp.626~633 (2007), 대한동의병리학회
- 백혜기, "加味淸熱導痰湯이 DOCA-salt로 유발된 고혈압 백서에 미치는 영향", 대한한방내과학회지, 29(3), pp.641~656 (2008), 대한한방내과학회
- 장개빈, "현토주역 경악전서", pp.972~ (2007), 법인문화사
- 대한내과학회 해리슨내과학 편집위원회, "HARRISON'S 내과학 제2권", pp.1596~1614 (2006), 도서출판 MIP
- 의학계열 교수 27인, "의학생리학", pp.173~ (2002), 도서출판정담
- 이귀녕, "임상병리파일", pp.95~ (2003), 의학문화사
- 전국한의과대학 본초학교수, "본초학", pp.160~ (2000), 영림사