작약감초탕의 항염증효과
Anti-inflammatory Effect of Jakyakgamcho-tang
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The present study investigated the anti-inflammatory effect of Jakyakgamcho-tang in lipopolysaccharide-exposed rats. The plasma concentration of IL-1β, IL-6 and TNF-α peaked at 5hrs after LPS injection, and these values of the 300 ㎎/㎏ Jakyakgamcho-tang group were lower than those of the control group. The plasma concentration of IL-10 peaked at 5hrs after LPS injection and the values of the Jakyakgamcho-tang groups were higher than those of the control group. In the liver cytokines measurement was done at 5hrs after LPS injection. The concentrations of liver IL-1β and IL-6 in the 300 ㎎/㎏ Jakyakgamcho-tang were lower than that of the control group. The concentrations of liver TNF-α, and IL-10 showed no significant differences among all the treatment groups. These results indicate that the Jakyakgamcho-tang has anti-inflammatory activities.
Abstract
The present study investigated the anti-inflammatory effect of Jakyakgamcho-tang in lipopolysaccharide-exposed rats. The plasma concentration of IL-1β, IL-6 and TNF-α peaked at 5hrs after LPS injection, and these values of the 300 ㎎/㎏ Jakyakgamcho-tang group were lower than those of the control group. The plasma concentration of IL-10 peaked at 5hrs after LPS injection and the values of the Jakyakgamcho-tang groups were higher than those of the control group. In the liver cytokines measurement was done at 5hrs after LPS injection. The concentrations of liver IL-1β and IL-6 in the 300 ㎎/㎏ Jakyakgamcho-tang were lower than that of the control group. The concentrations of liver TNF-α, and IL-10 showed no significant differences among all the treatment groups. These results indicate that the Jakyakgamcho-tang has anti-inflammatory activities.
참고문헌 (24)
- 張仲景, "仲景全書", pp.120~121 (1975), 醫道韓國社
- 吳儀洛, "本草從新", pp.6~ (1972), 杏林書院
- 汪昻, "本草備要", pp.2~ (1974), 高文社
- 龍野一雄, "新擇類聚方", pp.63~65 (1959), 漢方醫學大系刊行會
- 失數道明, "漢方處方解說", pp.234~240 (1966), 創元社
- 孟華燮, "黃今湯 및 黃今加半夏生薑湯의 治療例", 大韓韓醫學會報, 1(7), pp.16~18 (1963)
- 이윤석, "작약감초탕의 효능에 관한 연구", 동의생리병리학회지, 17(2), pp.493~498 (2003), 대한동의병리학회
- 山田光隀, "漢方處方應用の實際", pp.185~ (1967), 南山堂
- 和田正系, "漢方治療堤要", pp.65~66 (1964), 醫道の日本社
- 江田昭英, "Glycyrrhizinの藥理應用", 日藥理誌, 61, pp.130~ (1965)
- 坂口 弘, "甘草の解毒作用につけて", 日藥理誌, 55, pp.152~ (1959)
- 梶本義衛, "甘草成分の藥理學的硏究", 日藥理誌, 55, pp.153~ (1959)
- 高木敬次郞, "芍藥の藥理學的硏究 べオニフリンの中樞作用および甘草 成分 FM100 との 倂用効", 日藥誌, 89, pp.879~ (1969)
- 채인식, "傷寒論譯詮", pp.498~ (2006), 高文社
- Marriot, J. B, "CC-3052: a water-soluble analog of thalidomide and potent inhibitor of activation-induced TNF-α production", J Immunol., 161, pp.4236~4243 (1998)
- Mathiak, G, "Capase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses", Br J Pharmacol, 131, pp.383~386 (2000)
- Eduard FM, "Immunomodulatory effects of thalidomide analogs on LPS-induced plasma and hepatic cytokines in the rat", Biochemical pharmacology, 68, pp.1321~1329 (2004)
- Sang, H, "Expression of cytokines and activation of transcription factors in lipopolysaccharide -administered rats and their inhibition by phenyl N-tert-butylnitrone(PBN)", Arch Biochem Biophys., 363, pp.341~348 (1999)
- Chamulitrat, W, "Tumor necrosis factor-α and nitric oxide production in endotoxin -primed rats administered carbon tetrachloride", Life Sci, 24, pp.2273~2280 (1995)
- Harbrecht, B. G, "Tumor necrosis factor-α regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia", Hepatology, 20, pp.1055~1060 (1994)
- Hamada, E, "Activation of Kupffer cells and caspases-3 involved in rat hepatocyte apoptosis induced by endotoxin", J. Hepatol, 30, pp.807~818 (1999)
- Thompson, K. C, "Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro", Hepatology, 28, pp.1518~1524 (1998)
- Moreira, A. L, "Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation", J Exp Med, 177, pp.1675~1680 (1993)
- Simpson KJ, "Colletti L, Strieter RM, Kunkel SL. Cytokines and the liver", J Hepatol, 27, pp.1120~1132 (1997)