옻나무추출물 위주의 한방치료로 국소 진행된 비소세포폐암 환자의 잔존 종양의 관해와 생존기간이 연장된 사례
Case Study: Regression of a Residual Tumor and Prolongation of Overall Survival with Allergen-removed Rhus verniciflua Stokes after Chemoradiotherapy in Locally Advanced Non-small Cell Lung Cancer
1
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Objectives: The purpose of this study is to report the possibility of treatment of locally advanced non-small cell lung cancer with Traditional Korean Medicine based allergen-removed Rhus verniciflua Stokes (ARVS) following chemoradiotherapy. Methods: A patient with locally advanced non-small cell lung cancer (stage IIIB) felt chest discomfort, fatigue, and anxiety after chemoradiotherapy. To prevent recurrence, he opted to receive Traditional Korean Medicine. Results: After treatment with ARVS, the size of the residual primary cancer and a metastatic lymph node decreased, without new cancerous regions. The patient has maintained good performance and has shown prolonged overall survival. Conclusions: This report suggests that ARVS may play a therapeutic role in the treatment of locally advanced non-small cell lung cancer after chemoradiotherapy. Further studies will be needed to determine the effect of ARVS on locally-advanced unresectable non-small cell lung cancer.
Abstract
Objectives: The purpose of this study is to report the possibility of treatment of locally advanced non-small cell lung cancer with Traditional Korean Medicine based allergen-removed Rhus verniciflua Stokes (ARVS) following chemoradiotherapy. Methods: A patient with locally advanced non-small cell lung cancer (stage IIIB) felt chest discomfort, fatigue, and anxiety after chemoradiotherapy. To prevent recurrence, he opted to receive Traditional Korean Medicine. Results: After treatment with ARVS, the size of the residual primary cancer and a metastatic lymph node decreased, without new cancerous regions. The patient has maintained good performance and has shown prolonged overall survival. Conclusions: This report suggests that ARVS may play a therapeutic role in the treatment of locally advanced non-small cell lung cancer after chemoradiotherapy. Further studies will be needed to determine the effect of ARVS on locally-advanced unresectable non-small cell lung cancer.
참고문헌 (22)
- 사망원인통계 2012, "통계청 국가통계포털", ~
- Petrovich Z, "Radiotherapy in the management of locally advanced lung cancer of all cell types: final report of randomized trial", Cancer, 48, pp.1335~1340 (1981)
- Furuse K, "Phase Ⅲ study of concurrent versus sequential thoracic radiotherapy in combination with mytomycin, vindesine, and cisplatin in unresectable stage Ⅲ non-small-cell lung cancer", J clin Oncol, 17, pp.2692~2699 (1999)
- Sause W, "Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer: Radiation Therapy Oncology Group, Easten Cooperative Oncology Group, and Southwest Oncology Group", Chest, 117, pp.358~364 (2000)
- 배기채, "폐암의 변증과 치방에 관한 문헌적 고찰", 대전대학교 한의학연구소 논문집, pp.243~264 (1997)
- 엄석기, "옻의 主治·效能·修治法에 關한 小考 - 11종 한약서를 중심으로 -", 대한한의학원전학회지, 21(2), pp.29~38 (2008), 대한한의학원전학회
- Choi W, "Rhus verniciflua stokes against advanced cancer: a perspective from the Korean Integrative Cancer Center", J Biomed Biotechnol, pp.874276~ (2012)
- The World Health Report, "The World Health Organization", ~ (2003)
- Perez CA, "Long-term observations of the pattern of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy: report by the Radiation Therapy Oncology Group", Cancer, 59, pp.1874~1881 (1987)
- Fournel P, "Randomized phase Ⅲ trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Français de Pneumo-Cancérologie NPC 95-01Study", J Clin Oncol, 23(25), pp.5910~5917 (2005)
- Bejak A, "Definitive and Adjuvant Radiotherapy in Locally Advanced Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline", J Clin Oncol, 33(18), pp.2100~2105 (2015)
- Sang-JaAhn, "Outcomes after Radiotherapy in Inoperable Patients with Squamous Cell Lung Center", Radiation oncology journal, 19(3), pp.216~223 (2001), 대한방사선종양학회
- 이희관, "국소적으로 진행된 비소세포폐암의 치료성적", Radiation oncology journal, 24(4), pp.237~242 (2006), 대한방사선종양학회
- 전국한의과대학 본초학교실, "본초학", pp.439~ (1991), 영림사
- Jang HS, "Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells", Biochim Biophys Acta, 1726(3), pp.309~316 (2005)
- Kim JH, "Inhibition of cell cycle progression via p27Kip1 upregulation and apoptosis induction by an ethanol extract of Rhus verniciflua stokes in AGS gastric cancer cells", Int J Mol Med, 18(1), pp.201~208 (2006)
- Lee JD, "Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models", Int Immunopharmacol, 9(3), pp.268~276 (2009)
- 정의민, "감마나이프 시술 후 옻나무 추출물 투여로 전이성 뇌종양 소퇴 및 생존기간이 연장된 환자 1례", 대한한의학회지, 30(5), pp.157~162 (2009), 대한한의학회
- Lee SH, "Successful outcome of advanced pulmonary adenocarcinoma with malignant pleural effusion by the standardized rhus verniciflua stokes extract: a case study", Explore, 5(4), pp.242~244 (2009)
- 이진수, "항암화학요법과의 순차적, 그리고 병행적 요법으로서의 aRVS 투여로 장기 생존과 좋은 삶의 질을 유지한 전이성 비소세포폐암 증례보고", 대한한방내과학회지, 32(1), pp.129~135 (2011), 대한한방내과학회
- Cheon SH, "Efficacy and safety of Rhus verniciflua stokes extracts in patients with previously treated advanced non-small cell lung cancer", Forsch Komplementmed, 18(2), pp.77~83 (2011)
- Lee J, "The efficacy and safety of standardized allergen-removed Rhus verniciflua extract as maintenance therapy after first-line chemotherapy in patients with advanced non-small cell lung cancer", Am J Chin Med, 41(4), pp.773~787 (2013)