Well-Managed Myelodysplastic Syndrome Patients Treated with Traditional Korean Medicine; Report of Two Cases
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초록
Myelodysplastic syndrome (MDS) is a typical myeloid malignancy characterized by cell dysplasia in bone marrow. Currently, there is no therapeutic treatment for MDS. The only available therapies either relieve symptoms or prevent the development of acute myeloid leukemia (AML). This study aimed to report the effects of traditional Korean medicine (TKM) on MDS by presenting two case reports. The patient in Case 1 was diagnosed with primary MDS and regularly received acupuncture treatments and herbal medicine. In Case 2, a patient with ovarian cancer was diagnosed with secondary MDS, which resulted from an adverse reaction to chemotherapy. This patient took herbal medicine for four years and was hospitalized three times. In order to have their condition evaluated, both patients underwent regular blood tests. The patient in Case 1, who showed blood transfusion dependency, received only two blood transfusions after TKM treatment, and the person’s health condition was stable as of January 2016 without any signs of AML development. The patient in Case 2 also has stable health condition. TKM treatment effectively treated their MDS symptoms and improved their general health conditions without any adverse effects. It also prevented the rapid development of AML and maximized the effects of conservative therapy.
Abstract
Myelodysplastic syndrome (MDS) is a typical myeloid malignancy characterized by cell dysplasia in bone marrow. Currently, there is no therapeutic treatment for MDS. The only available therapies either relieve symptoms or prevent the development of acute myeloid leukemia (AML). This study aimed to report the effects of traditional Korean medicine (TKM) on MDS by presenting two case reports. The patient in Case 1 was diagnosed with primary MDS and regularly received acupuncture treatments and herbal medicine. In Case 2, a patient with ovarian cancer was diagnosed with secondary MDS, which resulted from an adverse reaction to chemotherapy. This patient took herbal medicine for four years and was hospitalized three times. In order to have their condition evaluated, both patients underwent regular blood tests. The patient in Case 1, who showed blood transfusion dependency, received only two blood transfusions after TKM treatment, and the person’s health condition was stable as of January 2016 without any signs of AML development. The patient in Case 2 also has stable health condition. TKM treatment effectively treated their MDS symptoms and improved their general health conditions without any adverse effects. It also prevented the rapid development of AML and maximized the effects of conservative therapy.
참고문헌 (18)
- Disperati P, "Progression of myelodysplasia to acute lymphoblastic leukaemia: implications for disease biology", Leuk Res, 30(2), pp.233~239 (2006)
- Cazzola M, "Myelodysplastic syndromescoping with ineffective hematopoiesis", N Engl J Med, 352(6), pp.536~538 (2005)
- Eun-Hye Park, "Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012", Blood Research, 50(4), pp.204~217 (2015), 대한혈액학회
- Aul C, "Age-related incidence and other epidemiological aspects of myelodysplastic syndromes", Br J Haematol, 82(2), pp.358~367 (1992)
- Tricot GJ, "Prognostic factors in the myelodysplastic syndromes", Leuk Res, 16(1), pp.109~115 (1992)
- Rollison DE, "Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs", Blood, 112(1), pp.45~52 (2008)
- Padron E, "The clinical management of chronic myelomonocytic leukemia", Clin Adv Hematol Oncol, 12(3), pp.172~178 (2014)
- García-Delgado R, "Effectiveness and safety of different azacitidine dosage regimens in patients with myelodysplastic syndromes or acute myeloid leukemia", Leuk Res, 38(7), pp.744~750 (2014)
- Kim JD, "A case of myelodysplastic syndrome", J Int Korean Med, 20(1), pp.274~279 (1999)
- 김병수, "삼원적 구조로 본 상수역학 체계- 四象？五行？六氣를 중심으로 -", 동의생리병리학회지, 21(5), pp.1065~1071 (2007), 한의병리학회
- Song HW, "Literature review on practical use of Sibjeondaebo-tang", J Herb Formula Sci, 4(1), pp.153~172 (1996)
- Lee MH, "Experimental studies on the hematopoietic effects of Cervi pantotrichum Cornu", pp.2001
- 이남헌, "항암단으로 치료한 암환자 100례의 혈청 VFGF, bEGF 및 platelet 수치 변화", 대한한방내과학회지, 26(4), pp.753~760 (2005), 대한한방내과학회
- Sekeres MA, "Characteristics of US patients with myelodysplastic syndromes:results of six cross-sectional physician surveys", J Natl Cancer Inst, 100(21), pp.1542~1551 (2008)
- Komrokji RS, "Prognostic factors and risk models in myelodysplastic syndromes", Clin Lymphoma Myeloma Leuk, 13(Suppl 2), pp.S295~S299 (2013)
- Klepin HD, "Acute Myeloid Leukemia and Myelodysplastic Syndromes in Older Adults", J Clin Oncol, 32(24), pp.2541~2552 (2014)
- Malcovati L, "Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes", J Clin Oncol, 25(23), pp.3503~3510 (2007)
- Malcovati L, "Predicting survival and leukemic evolution in patients with myelodysplastic syndrome", Haematologica, 91(12), pp.1588~1590 (2006)