Anti-hyperlipidemia and Anti-arteriosclerosis Effects of Laminaria japonica in Sprague-Dawley Rats
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초록
The anti-hyperlipidemic effects of dietary supplementation with sea tangle Laminaria japonica were investigated using an animal model in which normal rats were fed either sea tangle, sea tangle ethanol extract (EE-ST) and sea tangle extracted residue (ER-ST). Total lipid and triglyceride levels in the serum were significantly (P < 0.05) reduced in rats fed ER-ST at a dose of 200 mg/kg body weight when compared to hyperlipidemic control rats. Significant decreases in serum total cholesterol and low density lipoprotein-cholesterol levels also occurred in rats fed ER-ST at 200 mg/kg body weight. In addition, the atherosclerosis index and superoxide dismutase in blood lipids were significantly (P < 0.05) lowered in rats fed ER-ST at 200 mg/kg body weight as compared to control rats. In conclusion, sea tangle and ER-ST exhibited beneficial anti-hyperlipidemic and anti-arteriosclerosis effects.
Abstract
The anti-hyperlipidemic effects of dietary supplementation with sea tangle Laminaria japonica were investigated using an animal model in which normal rats were fed either sea tangle, sea tangle ethanol extract (EE-ST) and sea tangle extracted residue (ER-ST). Total lipid and triglyceride levels in the serum were significantly (P < 0.05) reduced in rats fed ER-ST at a dose of 200 mg/kg body weight when compared to hyperlipidemic control rats. Significant decreases in serum total cholesterol and low density lipoprotein-cholesterol levels also occurred in rats fed ER-ST at 200 mg/kg body weight. In addition, the atherosclerosis index and superoxide dismutase in blood lipids were significantly (P < 0.05) lowered in rats fed ER-ST at 200 mg/kg body weight as compared to control rats. In conclusion, sea tangle and ER-ST exhibited beneficial anti-hyperlipidemic and anti-arteriosclerosis effects.
참고문헌 (33)
- Akiba Y, "Effects of dietary fibers on lipid metabolism in liver and adipose tissue in chicks", J Nut, 112, pp.1577~1585 (1982)
- Bidlack WR, "Damage to microsomal membrane by lipid peroxidation", Lipids, 8, pp.177~182 (1973)
- Celik S, "Influence of vitamin E on the levels of fatty acids and MDA in some tissues of diabetic rats", Cell Biochem Funct, 20, pp.67~71 (2002)
- Chen WJ, "Effects of guar gum and wheat bran on lipid metabolism in rats", J Nutr, 109, pp.1028~1034 (1979)
- 조영자, "미역첨가 식이가 당뇨 유발쥐의 혈청지질과 혈당 및 항산화 효소에 미치는 영향", 한국식품영양과학회지, 33(6), pp.987~994 (2004), 한국식품영양과학회
- Choi JH, "Effects of sea tangle(Laminaria japonica)and fucoidan components on chronic degenerative diseases", Korean J Life Sci, 9, pp.430~438 (1999)
- Connor WE, "The interrelated effects of dietary cholesterol and fat upon human serum lipid levels", J Clin Invest, 43, pp.1691~1696 (1964)
- Folch J, "A simple method for the isolation and purification of total lipides from animal tissues", J Biol Chem, 226, pp.497~509 (1957)
- Friedwald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma,without use of the preparative ultracentrifuge", Clin Chem, 18, pp.499~502 (1972)
- Frings CS, "The colorimetric method for determination of total serum lipids based on the sulfo-phospho-vanillin reaction", Am J Clin Pathol, 53, pp.89~91 (1970)
- Goode GK, "Hyperlipidemia,hypertension,and coronary heart disease", Lancet, 345, pp.362~364 (1995)
- Hill JO, "Development of dietary obesity in rats:influence of amount and composition of dietary fat", Int J Obes Relat Metab Disord, 16, pp.321~333 (1992)
- Hsueh WA, "Hypertension,the endothelial cell,and the vascular complications of diabetic mellitus", Hypertension, 20, pp.253~263 (1992)
- Kang JY, "Anti-inflammatory activities of Undaria pinnatifida and Laminaria japonica(Phaeophyta)", 석사, pp.2008
- Kobatake Y, "Influence of fish consumption on serum lipid and lipid peroxide concentrations in middle aged subjects", J Jpn Soc Nutr Food Sci, 40, pp.103~110 (1987)
- Lahaye M, "Marine algae as sources of fibres:determination of soluble and insoluble dietary fibre contents in some ‘sea vegetables’", J Sci Food Agric, 54, pp.587~594 (1991)
- Lee HK, "Recent progress in obesity research:diseases associated with obesity", Korean J Nutr, 23, pp.341~346 (1990)
- Lehtonen A, "High-density lipoprotein cholesterol levels of very old people in the diagnosis of dementia", Age Ageing, 15, pp.267~270 (1986)
- Lowry OH, "Protein measurement with the folin phenol reagent", J Biol Chem, 193, pp.265~275 (1951)
- McGowan MW, "A peroxidase-coupled method for the colorimetric determination of serum triglycerides", Clin Chem, 29, pp.538~542 (1983)
- Ministry of Maritime Affairs and Fisheries, "Statistical Year Book of Maritime Affairs and Fisheries", pp.1092~1093 (1999), Ministry of Maritime Affairs and Fisheries
- Annual Report on the Cause of Death Statistics 2008, "National Statistical Office of Korea", ~ (2010)
- Nishide E, "Effects of alginates on the ingestion and excretion of cholesterol in the rat", J Appl Phycol, 5, pp.207~211 (1993)
- Nishino T, "The relationship between the molecular weight and the anticoagulant and activity of two types of fucan sulfates from the brown seaweed Ecklonia kurome", Agric Biol Chem, 55, pp.791~797 (1991)
- Oyanagui Y, "Reevaluation of assay methods and establishment of kit for superoxide dismutase activity", Anal Biochem, 142, pp.290~296 (1984)
- Park SH, "The effect of dietary fiber feeding on gastrointestinal functions and lipid and glucose metabolism in streptozotocin-induced diabetic rats", Korean J Nutr, 27, pp.311~322 (1994)
- Richmond W, "Use of cholesterol oxidase for assay of total and free cholesterol in serum by continuous-flow analysis", Clin Chem, 22, pp.1579~1588 (1976)
- Vahouny GV, "Dietary fibers.III.Effects of cholesterol absorption and metabolism in the rat", Am J Chin Nutr, 33, pp.2182~2191 (1980)
- Valko M, "Free radicals and antioxidants in normal physiological functions and human disease", Int J Biochem Cell Biol, 39, pp.44~84 (2007)
- Velthuis-te Wierik EJ, "Consumption of reduced-fat products:effects on parameters of anti-oxidative capacity", Eur J Clin Nutr, 50, pp.214~219 (1996)
- Yagi K, "Lipid peroxides and human diseases", Chem Phys Lipids, 45, pp.337~351 (1987)
- Yang JL, "Effects of dietary fibers on cholesterol metabolism in cholesterol-fed rats", J Korean Soc Food Nutr, 25, pp.392~398 (1996)
- Yim MJ, "Antiatherosclerosis animal study and the ket funtional compound Identification of the alginate extracted residue of sea tangle", 석사, pp.2007