천식환자 허실변증별 혈액 싸이토카인 및 임상적 특성에 관한 단면적 연구
A Cross-sectional Study of Deficiency-Excess Pattern Identification with Blood Cytokines and Characteristics of Patients with Asthma
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Objective: The aims of this study were to analyze deficiency-excess pattern identification and to compare the blood cytokines in patients with asthma. Methods: A total of 112 patients with asthma who met the inclusion and exclusion criteria were divided into deficiency syndrome and excess syndrome groups. Blood was examined for eotaxin, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), a Visual Analogue Scale (VAS), and heart rate variability (HRV) tests were administered to both groups. Results: Pattern identification divided the 112 patients into two categories: a deficiency syndrome group (N=52) and an excess syndrome group (N=60). Analysis of blood cytokines showed higher levels of IL-4, IL-5, and IL-13 in the deficient pattern than in the excess pattern group, but the difference was not statistically significant. Analysis of the HRV revealed a significantly higher mean value for the very-low-frequency (VLF) and high-frequency (HF) bands in the deficiency than in the excess syndrome group. The morbidity duration was longer in the deficiency than in the excess syndrome group, but the difference was not statistically significant. Analysis of the QLQAKA and VAS scores showed a negative correlation, whereas BMI and VAS showed a positive correlation. Conclusions: Levels of blood cytokines, including eotaxin, IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α, did not differ statistically between the deficiency and excess syndrome groups. The development of a more accurate asthma-specific pattern identification tool would be useful in asthma control.
Abstract
Objective: The aims of this study were to analyze deficiency-excess pattern identification and to compare the blood cytokines in patients with asthma. Methods: A total of 112 patients with asthma who met the inclusion and exclusion criteria were divided into deficiency syndrome and excess syndrome groups. Blood was examined for eotaxin, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), a Visual Analogue Scale (VAS), and heart rate variability (HRV) tests were administered to both groups. Results: Pattern identification divided the 112 patients into two categories: a deficiency syndrome group (N=52) and an excess syndrome group (N=60). Analysis of blood cytokines showed higher levels of IL-4, IL-5, and IL-13 in the deficient pattern than in the excess pattern group, but the difference was not statistically significant. Analysis of the HRV revealed a significantly higher mean value for the very-low-frequency (VLF) and high-frequency (HF) bands in the deficiency than in the excess syndrome group. The morbidity duration was longer in the deficiency than in the excess syndrome group, but the difference was not statistically significant. Analysis of the QLQAKA and VAS scores showed a negative correlation, whereas BMI and VAS showed a positive correlation. Conclusions: Levels of blood cytokines, including eotaxin, IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α, did not differ statistically between the deficiency and excess syndrome groups. The development of a more accurate asthma-specific pattern identification tool would be useful in asthma control.
참고문헌 (26)
- Fanta CH, "Asthma", N Engl J Med, 360(10), pp.1002~1014 (2009)
- "Korean guideline for asthma" (2015)[URL]
- 김성렬, "정밀한 천식 치료를 위한 생물학적 제제", Allergy Asthma & Respiratory Disease, 7(1), pp.3~12 (2019), 대한 소아알레르기 호흡기학회[DOI]
- Shergis JL, "Herbal medicine for adults with asthma:A systematic review", J Asthma, 53(6), pp.650~659 (2016)
- Brinkhaus B, "Acupuncture in Patients with Allergic Asthma:A Randomized Pragmatic Trial", J Altern Complement Med, 23(4), pp.268~277 (2017)
- An KS, "The System of Symptom Differentiation and Contents in Oriental Medicine", J Korean Oriental Medical Pathology, 2(1), pp.6~11 (1987)
- 유현희, "허실 변증 설문지 개발 가능성에 대한 고찰", 동의생리병리학회지, 23(3), pp.534~539 (2009), 한의병리학회
- Gan HJ, "Studies on Relationship Between Cold-heat Asthma at Stage of Attack of Bronchial Asthma and ET-1 and ANF", J of Shaanxi College of Traditional Chinese Medicine, 26(5), pp.64~66 (2003)
- Cao YX, "Biomarkers and inflammatory characteristics for microcosmic syndrome differentiation of cold-phlegm syndrome and heat-phlegm syndrome in patients with bronchial asthma", Zhongguo Zhong Xi Yi Jie He Za Zhi, 30(8), pp.828~832 (2010)
- 방연희, "喘息 환자의 虛實寒熱辨證과 특성 비교 분석", 대한한방내과학회지, 38(6), pp.955~970 (2017), 대한한방내과학회
- 도하윤, "천식환자 허실변증과 객담 cytokine 및 특성 비교분석", 대한한방내과학회지, 40(4), pp.582~596 (2019), 대한한방내과학회[DOI]
- "Note for guidance on the clinical investigation of medicinal products for treatment of asthma", KFDA, ~ (2007)
- Park JW, "Multi - center study for the utilization of quality of life questionnaire for adult Korean asthmatics (QLQAKA)", J Asthma Allergy Clin Immunol, 20(3), pp.467~479 (2000)
- Gil YS, "Review of Literatures on Allergic Asthma", J Korean Med, 11(1), pp.39~70 (1990)
- 장은수, "한방 건강검진에서 허실 변증 진단 설문지 개발-신뢰도와 구성 타당도를 중심으로-", 동의생리병리학회지, 32(3), pp.171~177 (2018), 한의병리학회[DOI]
- 이인선, "한방진단시스템 DSOM의 진단결과에 따른 월경통 환자의 진단에 대한 연구", Journal of Pharmacopuncture, 10(1), pp.137~156 (2007), 대한약침학회
- 이상엽, "천식의 면역학적 기전", Tuberculosis and Respiratory Diseases, 60(4), pp.379~390 (2006), 대한결핵및호흡기학회
- 유광하, "감염과 천식 발생에 관한 역학적 연구 가설", Tuberculosis and Respiratory Diseases, 65(1), pp.1~6 (2008), 대한결핵및호흡기학회
- 김민혜, "중증천식의 생물학적 제제 치료", 대한내과학회지, 93(2), pp.172~180 (2018), 대한내과학회
- Dunican EM, "The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations", Ann Am Thorac Soc, 12(Suppl 2), pp.S144~S149 (2015)
- 이현중, "중풍 환자의 입원 후 허실변증별 심박변이도 변화 특성에 대한 고찰", Korean Journal of Acupuncture, 33(4), pp.176~182 (2016), 경락경혈학회[DOI]
- Xhyheri B, "Heart rate variability today", Progress in Cardiovascular Diseases, 55(3), pp.321~331 (2012)
- Beuther DA, "Overweight, obesity, and incident asthma:a meta-analysis of prospective epidemiologic studies", Am J Respir Crit Care Med, 175(7), pp.661~666 (2007)
- Taylor B, "Body mass index and asthma severity in the National Asthma Survey", Thorax, 63(1), pp.14~20 (2008)
- Mosen DM, "The relationship between obesity and asthma severity and control in adults", J Allergy Clin Immunol, 122(3), pp.507~511 (2008)
- Peters U, "Obesity and asthma", J Allergy Clin Immunol, 141(4), pp.1169~1179 (2018)