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The Effectiveness of Traditional Korean Medicine for Treating Postoperative Ileus in Gastric Cancer Patients: A Systematic Review and Meta-Analysis

이남헌|김은지|서현식|배혜리
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2022.09|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제43권 제4호|pp. 625-642|DOI https://doi.org/10.22246/jikm.2022.43.4.625

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키워드

메타분석meta-analysis위암traditional Korean medicine한의학적 치료위절제술gastric cancergastrectomypostoperative ileus수술 후 장마비
주제분류한의학

초록

Objectives: Postoperative ileus (POI) is a common impairment of gastrointestinal motility and causes a delay in postoperative recovery, as well as an increased length of hospital stay, but no single strategy has a significant recuperative effect on POI. Studies of traditional Korean medicine (TKM) have reported improvements in bowel function after surgery. The aim of this systematic review was to assess the effectiveness of TKM on postoperative ileus in gastric cancer patients. Methods: We used six databases to search for studies published from January 1, 2007, until May 11, 2022. The included studies were those reporting gastric cancer patients who received TKM treatment after gastrectomy through indicators related to POI. Results: The search identified 27 RCTs that used herbal medicine (Daegeonjung-tang and Gami-leejoongtang), herbal medicine combined with acupuncture (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, acupuncture and moxibustion, electroacupuncture, warm needling, transcutaneous electroacupuncture (TEA), low-frequency electrical acupoint stimulation (LEAS), moxibustion, auricular acupressure, and ST-36 acupoint injection with neostigmine as treatments for POI. The time to first flatus was shortened by herbal medicine combined with warm needling (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, electroacupuncture, warm needling, TEA, moxibustion, auricular acupressure, and ​ST-36 acupoint injection with neostigmine (p<0.00001). The time to the first defecation decreased significantly in response to the herbal medicine combined with warm needling (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, electroacupuncture, warm needling, TEA, moxibustion, auricular acupressure, and ST-36 acupoint injection with neostigmine (p<0.00001). No serious adverse events occurred. Conclusions: TKM could be a promising option for preventing and resolving POI in gastric cancer patients after gastrectomy.

Abstract

Objectives: Postoperative ileus (POI) is a common impairment of gastrointestinal motility and causes a delay in postoperative recovery, as well as an increased length of hospital stay, but no single strategy has a significant recuperative effect on POI. Studies of traditional Korean medicine (TKM) have reported improvements in bowel function after surgery. The aim of this systematic review was to assess the effectiveness of TKM on postoperative ileus in gastric cancer patients. Methods: We used six databases to search for studies published from January 1, 2007, until May 11, 2022. The included studies were those reporting gastric cancer patients who received TKM treatment after gastrectomy through indicators related to POI. Results: The search identified 27 RCTs that used herbal medicine (Daegeonjung-tang and Gami-leejoongtang), herbal medicine combined with acupuncture (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, acupuncture and moxibustion, electroacupuncture, warm needling, transcutaneous electroacupuncture (TEA), low-frequency electrical acupoint stimulation (LEAS), moxibustion, auricular acupressure, and ST-36 acupoint injection with neostigmine as treatments for POI. The time to first flatus was shortened by herbal medicine combined with warm needling (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, electroacupuncture, warm needling, TEA, moxibustion, auricular acupressure, and ​ST-36 acupoint injection with neostigmine (p<0.00001). The time to the first defecation decreased significantly in response to the herbal medicine combined with warm needling (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, electroacupuncture, warm needling, TEA, moxibustion, auricular acupressure, and ST-36 acupoint injection with neostigmine (p<0.00001). No serious adverse events occurred. Conclusions: TKM could be a promising option for preventing and resolving POI in gastric cancer patients after gastrectomy.

참고문헌 (59)

  1. Sung HA, "Global Cancer Statistics 2020 : globocan estimates of incidence and mortality worldwide for 36 cancers in 185countries", CA Cancer J Clin, 71(3), pp.209~249 (2021)
  2. Korenaga D, "Results of Resection of Gastric Cancer Extending to Adjacent Organs", Br J Surg, 75(1), pp.12~15 (1988)
  3. Martin R, "Achieving RO Resection for Locally Advanced Gastric Cancer : is it worth the risk of multiorgan resection?", J Am Coll Surg, 194(5), pp.568~577 (2002)
  4. Liedman B, "Symptoms after Total Gastrectomy on Food Intake, Body Composition, Bone Metabolism, and Quality of Life in Gastric Cancer Patients—Is Reconstruction with a Reservoir Worthwhile?", Nutrition, 15(9), pp.677~682 (1999)
  5. Waldhausen JHT, "Gastrointestinal Myoelectric and Clinical Patterns of Recovery after Laparotomy", Ann Surg, 211(6), pp.777~785 (1990)
  6. Artinyan A, "Prolonged Postoperative Ileus-Definition, Risk factors, and Predictors after Surgery", World J Surg, 32(7), pp.1495~1500 (2008)
  7. Vather R, "Defining Postoperative Ileus : Results of a Systematic Review and Global Survey", J Gastrointest Surg, 17(5), pp.962~972 (2013)
  8. Mortensen K, "Consensus Guidelines for Enhanced Recovery after Gastrectomy : enhanced recovery after surgery(ERAS®)society recommendations", Br J Surg, 101(10), pp.1209~1229 (2014)
  9. Iyer S, "Economic Burden of Postoperative Ileus Associated", J Manag Care Pharm, 15(6), pp.485~494 (2009)
  10. Kehlet H, "Fast-track colorectal surgery", Lancet, 371(9615), pp.791~793 (2008)
  11. Miedema BW, "Methods for Decreasing Postoperative Gut Dysmotility", Lancet Oncol, 4(6), pp.365~372 (2003)
  12. Wattchow D, "Postoperative Ileus—An Ongoing Conundrum", Neurogastroenterol Motil, 33(5), pp.1~11 (2021)
  13. Fang JF, "Electroacupuncture Treatment Partly Promotes the Recovery Time of Postoperative Ileus by Activating the Vagus Nerve but Not Regulating Local Inflammation", Sci Rep, 7, pp.39801~ (2017)
  14. Ishizuka M, "Perioperative Administration of Traditional Japanese Herbal Medicine Daikenchuto Relieves Postoperative Ileus in Patients Undergoing Surgery for Gastrointestinal Cancer : a systematic review and meta-analysis", Anticancer Res, 37(11), pp.5967~5974 (2017)
  15. Liu Y, "Acupuncture and Related Therapies for Treatment of Postoperative Ileus in Colorectal Cancer : a systematic review and meta-analysis of randomized controlled trials", Evidence-based Complement Altern Med, 22, pp.1~18 (2018)
  16. You X, "Zusanli(ST36)Acupoint Injection with Neostigmine for Paralytic Postoperative Ileus Following Radical Gastrectomy for Gastric Cancer : a randomized clinical trial", J Cancer, 9(13), pp.2266~2274 (2018)
  17. Chen KB, "Transcutaneous Electroacupuncture Alleviates Postoperative Ileus after Gastrectomy : a randomized clinical trial", World J Gastrointest Surg, 10(2), pp.13~ (2018)
  18. Phase P, "Effect of Daikenchuto, a Traditional Japanese Herbal Medicine, after Total Gastrectomy for Gastric Cancer : a multicenter, randomized, double-blind, placebo-controlled, phase II trial", Journal of the American College of Surgeons, 221(2), pp.571~578 (2015)
  19. 정세윤, "Effect of Acupuncture on Postoperative Ileus after Distal Gastrectomy for Gastric Cancer", Journal of Gastric Cancer, 17(1), pp.11~20 (2017), 대한위암학회[DOI]
  20. Akamaru Y, "Effects of Daikenchuto, a Japanese Herb, on Intestinal Motility After Total Gastrectomy : a prospective randomized trial", J Gastrointest Surg, 19(3), pp.467~472 (2015)
  21. Zhou X, "Effects of Transcutaneous Electrical Acupoint Stimulation(TEAS)on Postoperative Recovery in Patients with Gastric Cancer : a randomized controlled trial", Cancer Manag Res, 13, pp.1449~1458 (2021)
  22. He Dan, "Effect of Low-frequency Electrical Acupoint Stimulation on Gastrointestinal Motility Function Following Radical Gastrectomy in Patients with Gastric Cancer", Acupunct Res Jan, 45(1), pp.51~56 (2020)
  23. Chen QQ, "Effect of Simotang Oral Liquid and Warm Acupuncture on Gastrointestinal Function and Peripheral Blood Leukocyte after Operation in Patients with Gastric Cancer", J Qiqihar Med Univ, 3(April), pp.49~58 (2015)
  24. Cheng CH, "Effect of Jiuwei Chengqi Oral Liquid Combined with Warm Acupuncture and Moxibustion on Gastrointestinal Function and Peripheral Leukocytes in Middle－aged and Elderly Patients with Gastric Cancer after Total Gastrectomy", CJGMCM Novemb, 34(21), pp.3279~3281 (2019)
  25. Huang WJ, "The Effectiveness of Auricular Pressure on Gastrointestinal Function Recovery of Postoperative Patients with Gastric Cancer", J Nurs Adm, 14(11), pp.827~829 (2014)
  26. Nan N, "Effect of Auricular Acupressure on Gastrointestinal Function and Serum Gastrointestinal Hormone after Radical Gastrectomy", China Mod Dr, 56(32), pp.92~94 (2018)
  27. Qian CL, "Clinical Study on Acupuncture at Lower He-Sea Point for Promoting Functional Recovery after Stomach Cancer Surgery", Shanghai J Acupunct Moxibustion, 36(9), pp.1044~1048 (2017)
  28. Ren D, "Clinical Effect of Moxibustion on Abdominal Distension after Gastric Cancer Operation", J new Chinese Med Novemb, 48(11), pp.184~185 (2016)
  29. Tan P, "Influence of Ear Acupoint Pressing Beans on Gastrointestinal Function in Elderly Patients after Gastric Cancer Operation", Chinese Nurs Res December, 31(35), pp.4562~4564 (2017)
  30. Wang AJ, "Effect of Warm Needling on Gastrointestinal Function Recovery after Gastrointestinal Cancer Operation", Med Equipment, 31(4), pp.125~126 (2018)
  31. Xu R, "Clinical Study on Moxibustion and Ligitongfufang Footbath for Promoting Gastrointestinal Functional Recovery of Postoperative Gastric Cancer Patients", Jiangsu J Tradit Chinese Med, 49(12), pp.62~64 (2017)
  32. Ye GD, "The Value of Auricular Acupressure in Promoting the Rapid Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Surgery", China Mod Dr Novemb, 56(33), pp.153~156 (2018)
  33. Yin SH, "Clinical Study on Acupuncture Combined with Medication in Restoration of Gastrointestinal Functions for Postoperative Patients with Gastric Cancer", Chinese Acupunct Moxibustion, 29(6), pp.459~462 (2009)
  34. Zhang YW, "Effect of Moxibustion on Recovery of Gastrointestinal Motility Function after Gastric Cancer Operation", Nurs Rehabil J, 8, pp.795~796 (2014)
  35. Yang L, "Effect of Acupuncture for Regulating Qi and Unblocking Fu-Organs on Postoperative Gastrointestinal Function Recovery of Patients After Radical Gastrectomy for Gastric Cancer", New Chinese, 54(9), pp.143~147 (2022)
  36. Zhang LJ, "Effect of Timing Moxibustion on Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Operation", Chinese and Foreign Medical Research, 19(30), pp.166~168 (2021)
  37. Kang WZ, "Evaluation of acupoint acupuncture and moxibustion for promotion of recovery of gastrointestinal function after laparoscopic radical gastrectomy for gastric cancer", Chin J Clin Oncol Ｒehabil, 28(10), pp.1158~1161 (2021)
  38. Li XS, "Efficacy of Dachengqi decoction combined with acupuncture for recovery of gastrointestinal function and function of the immune system after surgery for gastric cancer", Chin J Clin Oncol Ｒehabil, 28(11), pp.1367~1370 (2021)
  39. Guo JH, "The Effect of Renshen Decoction Combined with Acupuncture on the Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Operation", Chinese Med Mod Distance Educ China, 19(16), pp.120~122 (2021)
  40. Wu J, "Effects of Warm Acupuncture Combined with Acupoint Massage on Serum Gastrin Motilin Level and Gastrointestinal Function in Patients with Gastric Cancer after Operation", Chin J Clin Res, 34(2), pp.232~235 (2021)
  41. Huang YB, "Curative Effect of Modified Lizhong Tang for Gastrointestinal Dysfunction after Operation for Gastric Cancer and its Effect on Early Recovery of Gastrointestinal Function", J New Chinese Med, 54(1), pp.150~153 (2022)
  42. Ding YQ, "Electroacupuncture treatment in gastric cancer patients : a RCT research for enhanced recovery after surgery", Journal of Baotou Medical College, 37(3), pp.107~110 (2021)
  43. Luckey A, "Mechanisms and Treatment of Postoperative Ileus", Arch Surg, 138(2), pp.206~214 (2003)
  44. Khawaja ZH, "Prevention and Management of Postoperative Ileus : a review of current practice", Cureus, 14(2), pp.e22652~ (2022)
  45. Bowker B, "Postoperative Ileus", Physician Assist Clin, 6(2), pp.215~227 (2021)
  46. Okada M, "Mechanism of Electroacupuncture on Postoperative Ileus Induced by Surgical Stress in Rats", Med Acupunct, 31(2), pp.109~115 (2019)
  47. Deng J, "Acupuncture Ameliorates Postoperative Ileus via IL-6-miR-19a-KIT Axis to Protect Interstitial Cells of Cajal", Am J Chin Med, 45(4), pp.737~755 (2017)
  48. Deng JJ, "Acupuncture Protects the Interstitial Cells of Cajal by Regulating miR-222 in a Rat Model of Post-operative Ileus", Acupunct Med, 37(2), pp.125~132 (2019)
  49. Hulzinga JD, "W", kit gene Required for Interstitial Cells of Cajal and for Intestinal Pacemaker Activity, 1995, pp.373(6512), 347~349
  50. Yang NN, "Effects of Electroacupuncture on the Intestinal Motility and Local Inflammation are Modulated by Acupoint Selection and Stimulation Frequency in Postoperative Ileus Mice", Neurogastroenterol Motil, 32(5), pp.e13808~ (2020)
  51. Muller PA, "Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility", Cell, 158(2), pp.300~313 (2014)
  52. 한가진, "가미도홍사물탕 약욕요법 이후 호전된 항암화학요법 유발 수족증후군 1례", 대한한방내과학회지, 39(2), pp.259~267 (2018), 대한한방내과학회
  53. Sakakibara R, "Dietary Herb Extract Dai-kenchu-to Ameliorates Constipation in Parkinsonian Patients(Parkinson’s disease and multiple system atrophy)", Mov Disord, 20(2), pp.261~262 (2005)
  54. Ohya T, "Effect of Dai-kenchu-to on Obstructive Bowel Disease in Children", Am J Chin Med, 31(1), pp.129~135 (2003)
  55. Iwai N, "Effects of Herbal Medicine Dai-Kenchu-To on Anorectal Function in Children with Severe Constipation", Eur J Pediatr Surg, 17(2), pp.115~118 (2007)
  56. Nakamura T, "Abatement of Morphine-Induced Slowing in Gastrointestinal Transit by Dai-kenchu-to, a Traditional Japanese Herbal Medicine", Jpn J Pharmacol, 88(2), pp.217~221 (2002)
  57. Furukawa Y, "Effects of the Chinese Herb Medicine"Dai-kenchu-to"on GI Motility and for Treatment of Bowel Obstruction", Gastroenterology, 116, pp.A811~ (1999)
  58. Satoh K, "Effect of Dai-kenchu-to(Da-Jian-Zhong-Tang)on the Delayed Intestinal Propulsion Induced by Chlorpromazine in Mice", J Ethnopharmacol, 86(1), pp.37~44 (2003)
  59. Hayakawa T, "Effects of Dai-kenchu-to on Intestinal Obstruction Following Laparotomy", J Smooth Muscle Res, 35(2), pp.47~54 (1999)

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