염증성 장질환 환자에서 저탄수화물 식이요법을 병행한 한약 치료의 체중 감량 효과 및 안전성 평가 : 후향적 다기관 연구
Treatment Response and Safety of Herbal Medicine Combined with a Low-Carbohydrate Diet for Weight Reduction in Patients with Inflammatory Bowel Disease: A Retrospective Multicenter Study
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Objective: This study evaluated the effects of herbal medicine combined with a low-carbohydrate diet on weight loss and disease progression in patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Methods: A retrospective analysis was conducted on 14 IBD patients (12 UC, 2 CD) who received 60 days of herbal medicine in solid form (pills, tablets, and capsules) and followed a low-carbohydrate diet (50 g/day limit). Body weight and composition were measured before and after treatment, and adverse events were recorded to assess safety. Results: Mean body weight decreased significantly, from 73.00±18.25 kg to 67.98±16.09 kg (p<0.05), with an average weight loss of 6.88%. BMI decreased from 26.84±4.59 kg/m2 to 25.00±4.06 kg/m2. Body fat mass and body fat percentage were significantly reduced, indicating fat loss. Seven patients (50%) reported mild to moderate adverse events, including nausea, indigestion, abdominal pain, sleep disturbances, and headaches. Most patients showed stabilization or improvement in IBD symptoms, such as normalized bowel movements. Conclusion: Herbal medicine combined with a low-carbohydrate diet resulted in significant weight loss and positive effects on IBD symptoms, without serious side effects. Further studies are needed to validate these findings.
Abstract
Objective: This study evaluated the effects of herbal medicine combined with a low-carbohydrate diet on weight loss and disease progression in patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Methods: A retrospective analysis was conducted on 14 IBD patients (12 UC, 2 CD) who received 60 days of herbal medicine in solid form (pills, tablets, and capsules) and followed a low-carbohydrate diet (50 g/day limit). Body weight and composition were measured before and after treatment, and adverse events were recorded to assess safety. Results: Mean body weight decreased significantly, from 73.00±18.25 kg to 67.98±16.09 kg (p<0.05), with an average weight loss of 6.88%. BMI decreased from 26.84±4.59 kg/m2 to 25.00±4.06 kg/m2. Body fat mass and body fat percentage were significantly reduced, indicating fat loss. Seven patients (50%) reported mild to moderate adverse events, including nausea, indigestion, abdominal pain, sleep disturbances, and headaches. Most patients showed stabilization or improvement in IBD symptoms, such as normalized bowel movements. Conclusion: Herbal medicine combined with a low-carbohydrate diet resulted in significant weight loss and positive effects on IBD symptoms, without serious side effects. Further studies are needed to validate these findings.
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