과체중 및 비만 성인 대상 감비탕 복용 효과에 대한 후향적 분석
A Retrospective Analysis of the Effectiveness of Taking Gambi-tang in Overweight and Obese Adults
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives: To investigate the weight loss effect of Gambi-tang in obese and overweight adults. Methods: From September 1, 2016 to December 31, 2021, a retrospective chart analysis was conducted on adult men and women who were prescribed Gambi-tang to address obesity and overweight in the National Medical Center (NMC). Partial analysis by age, obesity (Body Mass Index, BMI), duration of dose, and cumulative dose was also conducted. Results: The weight and BMI of the study subjects showed a significant decrease of more than 5% on average before and after treatment. In an analysis of age, significant differences by age could not be confirmed. In the analysis by obesity level, the effect of reducing weight, body fat, and abdominal fat rates in the obese and highly obese groups was greater than in the normal and overweight groups. There was no significant difference by group in the analysis by dosage period. In the analysis by cumulative dose, the greater the cumulative dose up to 1,800 g, the greater the decrease in weight and body fat. The side effect that patients appealed to the most was misjudgment, but not to a serious extent. Conclusions: Gambi-tang has been shown to be effective in weight and body fat loss for both obese and overweight adult men and women.
Abstract
Objectives: To investigate the weight loss effect of Gambi-tang in obese and overweight adults. Methods: From September 1, 2016 to December 31, 2021, a retrospective chart analysis was conducted on adult men and women who were prescribed Gambi-tang to address obesity and overweight in the National Medical Center (NMC). Partial analysis by age, obesity (Body Mass Index, BMI), duration of dose, and cumulative dose was also conducted. Results: The weight and BMI of the study subjects showed a significant decrease of more than 5% on average before and after treatment. In an analysis of age, significant differences by age could not be confirmed. In the analysis by obesity level, the effect of reducing weight, body fat, and abdominal fat rates in the obese and highly obese groups was greater than in the normal and overweight groups. There was no significant difference by group in the analysis by dosage period. In the analysis by cumulative dose, the greater the cumulative dose up to 1,800 g, the greater the decrease in weight and body fat. The side effect that patients appealed to the most was misjudgment, but not to a serious extent. Conclusions: Gambi-tang has been shown to be effective in weight and body fat loss for both obese and overweight adult men and women.
참고문헌 (27)
- Heymsfield SB, "Mechanisms, Pathophysiology, and Management of Obesity", N Engl J Med, 376(15), pp.1490~1492 (2017)
- Apovian CM, "Obesity : definition, comorbidities, causes, and burden", Am J Manag Care, 22(7), pp.176~185 (2016)
- Korea National Health and Nutrition Examination Survey, "Korea Centers for Disease Control and Prevention", ~ (2020)
- Stampfer MJ, "A prospective study of cholestererol, apolipoproteins and the risk of myocardial infarction", N Engl J Med, 325(6), pp.373~381 (1991)
- Salmon AB, "Beyond Diabetes : Does Obesity-Induced Oxidative Stress Drive the Aging Process?", Antioxidants, 5(3), pp.24~ (2016)
- Johansson K, "Discontinuation due to adverse events in randomized trials of orlistat, sibutramine and rimonabant : a meta-analysis", Obes Rev, 10(5), pp.564~575 (2009)
- Weber C, "Effect of the lipase inhibitor orlistat on the pharmacokinetics of four different antihypertensive drugs in healthy volunteers", Eur J Clin Pharmacol, 51(1), pp.87~90 (1996)
- 강순아, "비만관련 한약혼합제제의 비만에 대한 효과", 대한본초학회지, 18(4), pp.59~64 (2003), 대한본초학회
- Song HO, "Effect of ephedra sinica extract on the changes of the weight, appetite, plasma and UCP1, PPARα, PGC-1α mRNA expression in zucker rats", Dept. of Clinical Korean Medicine, pp.2006
- Yoo HJ, "Effects of Ephedrine-Containing Products on Weight Loss and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials", Pharmaceuticals(Basel), 14(11), pp.1198~ (2021)
- Shekelle PG, "Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance : a metaanalysis", JAMA, 289(12), pp.1537~1545 (2003)
- Lee KS, "A Clinical Study on the Effects of Obesity Treatment of Oriental Medicine", The Journal of Kyung Hee University Medical Center, 14(3), pp.303~308 (1998)
- 신승우, "감로수(甘露水)를 이용한 절식요법의 임상결과에 관한 후향적 관찰연구", 한방비만학회지, 16(1), pp.36~49 (2016), 한방비만학회
- 최현, "비만 및 과체중 여성 환자에서 한약 처방의 치료 효과에 대한 후향적 분석", 대한한방부인과학회지, 29(3), pp.35~46 (2016), 대한한방부인과학회[DOI]
- 조민진, "비만 치료 연구에서 마황의 안전성 분석", 한방비만학회지, 21(2), pp.95~104 (2021), 한방비만학회[DOI]
- 全國韓醫科大學本草學敎授, "本草學", pp.121~123 (1991), 영림사
- 이혜인, "황기맥문동탕이 에스트로겐 결핍 Rat의 체중 변화와 비만 관련 유전자 발현에 미치는 영향", 대한한방부인과학회지, 31(2), pp.49~67 (2018), 대한한방부인과학회[DOI]
- 변부형, "Inhibition of mTOR signaling pathway by aqueous extract of Siberian ginseng", 대한한의학회지, 38(2), pp.7~14 (2017), 대한한의학회[DOI]
- 황정수, "차전자·복령의 복합 물추출물(CJB)이 고지방사료로 유도된 비만 생쥐의 조직형태 및 조직병리학적 변화에 미치는 영향", 대한본초학회지, 28(1), pp.91~96 (2013), 대한본초학회
- Jo DH, "Effects of Gambisan in overweight adults and adults with obesity: A retrospective chart review", Medicine(Baltimore), 98(47), pp.e18060~ (2019)
- 조홍석, "H 감비탕(GB-001)이 폐경 전⋅후 비만 여성의 체중감량에 미치는 영향에 대한 후향적 연구", 한방비만학회지, 20(1), pp.20~30 (2020), 한방비만학회[DOI]
- Shannon JR, "Acute effect of ephedrine on 24-h energy balance", Clinical Science, 96(5), pp.483~491 (1999)
- 조가원, "비만 치료에서 마황 및 에페드린의 유효성, 안전성에 대한 고찰 - RCT 연구를 중심으로 -", 대한한의학회지, 38(3), pp.170~184 (2017), 대한한의학회[DOI]
- Song YK, "Clinical Application of Ma Huang in the Obesity Treatment", Journal of Society of Korean Medicine for Obesity Research, 7(1), pp.1~7 (2007)
- 황미자, "한국에서 비만치료에 쓰이는 한약에 대한 문헌 연구-2000년 이후 발표된 논문을 중심으로", 한방재활의학과학회지, 16(3), pp.65~81 (2006), 한방재활의학과학회
- 김수전, "한국에서 비만 치료에 쓰이는 한약에 대한 연구 동향 보고: 2015년부터 2019년까지의 국내외 논문을 중심으로", 한방재활의학과학회지, 30(4), pp.89~103 (2020), 한방재활의학과학회[DOI]
