코로나 관련 소화불량을 호소하는 환자의 임상적 특징 및 치료 분석 : 후향적 차트 분석
Analysis of Clinical Features and Treatment of Patients Presenting Dyspepsia Related to COVID-19: Retrospective Chart Review
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Objectives: The main purpose of this study is to investigate the clinical characteristics of patients complaining of indigestion after COVID-19 infection (CI) or COVID-19 vaccination (CV) and to confirm the effectiveness and safety of Korean medical treatment. Methods: We retrospectively collected and investigated the medical records of 39 patients admitted to the Kyung Hee University Korean Medicine Hospital with a chief complaint of dyspepsia from January 1, 2020 to February 29, 2024 who reported the onset or significant exacerbation of dyspepsia after CV or CI. Patients were divided into vaccination and infection groups, and their demographic characteristics, Ryodoraku results, presenting symptoms, traditional Korean medicine treatments, and treatment outcomes were analyzed. Results: When comparing the groups with dyspepsia after CV and after CI, it was observed that the CI group had significantly lower average body weight, and the measurements of LH6, LF1, and LF6 in the Ryodoraku test were significantly lower. Additionally, compared to the CV group, the CI group showed significantly more abdominal distension, nausea, and abdominal pain. Significant relief of upper gastrointestinal symptoms was observed in both the CV and CI groups after treatment. No adverse reactions were observed during the course of treatment. Conclusion: The CI group tended to complain more severely of various dyspeptic symptoms and had a tendency to lower body weight than the CV group, as was also reflected in the results of the Ryodoraku test. Korean medical treatment can be effective and safe in treating these patients.
Abstract
Objectives: The main purpose of this study is to investigate the clinical characteristics of patients complaining of indigestion after COVID-19 infection (CI) or COVID-19 vaccination (CV) and to confirm the effectiveness and safety of Korean medical treatment. Methods: We retrospectively collected and investigated the medical records of 39 patients admitted to the Kyung Hee University Korean Medicine Hospital with a chief complaint of dyspepsia from January 1, 2020 to February 29, 2024 who reported the onset or significant exacerbation of dyspepsia after CV or CI. Patients were divided into vaccination and infection groups, and their demographic characteristics, Ryodoraku results, presenting symptoms, traditional Korean medicine treatments, and treatment outcomes were analyzed. Results: When comparing the groups with dyspepsia after CV and after CI, it was observed that the CI group had significantly lower average body weight, and the measurements of LH6, LF1, and LF6 in the Ryodoraku test were significantly lower. Additionally, compared to the CV group, the CI group showed significantly more abdominal distension, nausea, and abdominal pain. Significant relief of upper gastrointestinal symptoms was observed in both the CV and CI groups after treatment. No adverse reactions were observed during the course of treatment. Conclusion: The CI group tended to complain more severely of various dyspeptic symptoms and had a tendency to lower body weight than the CV group, as was also reflected in the results of the Ryodoraku test. Korean medical treatment can be effective and safe in treating these patients.
참고문헌 (31)
- Zhu N, "A Novel Coronavirus from Patients with Pneumonia in China, 2019", N Engl J Med, 382(8), pp.727~733 (2020)
- "The end of an emergency", Nat Hum Behav, 7(5), pp.657~658 (2023)
- "Naming the coronavirus disease (COVID-19) and the virus that causes it"[URL]
- Green MS, "Did the hesitancy in declaring COVID-19a pandemic reflect a need to redefine the term?", Lancet, 395(10229), pp.1034~1035 (2020)
- Lim S, "How to cope with emerging viral diseases : lessons from South Korea's strategy for COVID-19, and collateral damage to cardiometabolic health", Lancet Reg Health West Pac, 30, pp.100581~ (2023)
- Scholkmann F, "COVID-19, post-acute COVID-19 syndrome(PACS, "long COVID")and post-COVID-19 vaccination syndrome(PCVS, "post-COVIDvac-syndrome") : Similarities and differences", Pathol Res Pract, 246, pp.154497~ (2023)
- Jeong HS, "Signal detection of COVID-19vaccines adverse events using spontaneous reports from South Korea", Pharmacoepidemiol Drug Saf, 32(9), pp.961~968 (2023)
- Chen C, "Global Prevalence of Post-Coronavirus Disease 2019(COVID-19)Condition or Long COVID : A Meta-Analysis and Systematic Review", J Infect Dis, 226(9), pp.1593~1607 (2022)
- Kim Y, "Preliminary Guidelines for the Clinical Evaluation and Management of Long COVID", Infect Chemother, 54(3), pp.566~597 (2022)
- Kim Y, "Significance and Associated Factors of Long-Term Sequelae in Patients after Acute COVID-19 Infection in Korea", Infect Chemother, 53(3), pp.463~476 (2021)
- Kim Y, "Post-acute COVID-19syndrome in patients after 12 months from COVID-19 infection in Korea", BMC Infect Dis, 22(1), pp.93~ (2022)
- Rome Foundation Research Institute, "Prolonged Gastrointestinal Manifestations After Recovery From COVID-19", Clin Gastroenterol Hepatol, 22(5), pp.1098~1107 (2024)
- Davis HE, "Long COVID : major findings, mechanisms and recommendations", Nat Rev Microbiol, 21(3), pp.133~146 (2023)
- Lee DS, "Significance of digestive symptoms after COVID-19 vaccination : A retrospective singlecenter study", Am J Emerg Med, 58, pp.154~158 (2022)
- Qian Q, "Direct Evidence of Active SARS-CoV-2Replication in the Intestine", Clin Infect Dis, 73(3), pp.361~366 (2021)
- Enaud R, "The Gut-Lung Axis in Health and Respiratory Diseases : A Place for Inter-Organ and Inter-Kingdom Crosstalks", Front Cell Infect Microbiol, 10, pp.9~ (2020)
- Cosentino M, "Understanding the Pharmacology of COVID-19 mRNA Vaccines : Playing Dice with the Spike?", Int J Mol Sci, 23(18), pp.10881~ (2022)
- Yang Z, "Traditional Chinese medicine against COVID-19 : Role of the gut microbiota", Biomed Pharmacother, 149, pp.112787~ (2022)
- Yu X, "Comparison of clinical efficacy of Qingfei Paidu decoction combined with western medicine in 43 cases and single western medicine in 46 cases in the treatment of COVID-19", Journal of Shandong University(Health Sciences), 8(12), pp.47~53 (2020)
- Wang R, "Protective effect of polysaccharides fractions from Sijunzi decoction in reserpine-induced spleen deficiency rats", RSC advances, 6(65), pp.60657~60665 (2016)
- Dhar J, "Corona Virus Disease-19 pandemic : The gastroenterologists'perspective", Indian J Gastroenterol, 39(3), pp.220~231 (2020)
- Zhou P, "A pneumonia outbreak associated with a new coronavirus of probable bat origin", Nature, 579(7798), pp.270~273 (2020)
- Futagami S, "Systematic review with meta-analysis : post-infectious functional dyspepsia", Aliment Pharmacol Ther, 41(2), pp.177~188 (2015)
- Tack J, "Clinical and pathophysiological characteristics of acute-onset functional dyspepsia", Gastroenterology, 122(7), pp.1738~1747 (2002)
- Dizdar V, "Increased visceral sensitivity in Giardia-induced postinfectious irritable bowel syndrome and functional dyspepsia. Effect of the 5HT3-antagonist ondansetron", Neurogastroenterol Motil, 19(12), pp.977~982 (2007)
- Porter CK, "The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population", Am J Gastroenterol, 106(1), pp.130~138 (2011)
- Committee of biofunctional medicine of whole Korean medicine university, "Biofunctional medicine", pp.132~144 (2014), Koonja publisher
- Yoshio N, "A Guide for Application of Ryodoraku Autonomous Nerve Regulatory Therapy", Ryodoraku Medicine and Stimulus Therapy, 1, pp.1~20 (2018)
- Kim DW, "A Case Report of Korean Medicine Treatment for a Patient with Early Dumping Syndrome with Diarrhea and Abdominal Pain after Gastrectomy", J Int Korean Med, 41(5), pp.868~876 (2020)
- Park SE, "Clinical Effect of Pyungjingunbitanggagam-bang on CVA Patients with Hyperlipidemia", Korean J Orient Int Med, 27(3), pp.561~572 (2006)
- Cho JH, "Review on Effects of Hyangsapyeongwi-san in Gastrointestinal Diseases", Korean J Oriental Physiology & Pathology, 24(1), pp.22~25 (2010)
