철결핍성 빈혈의 한약 치료에 대한 최근 중의 임상 연구 분석 : 체계적 문헌 고찰과 메타분석
A Review of Recent Chinese Clinical Studies on Traditional Herbal Medicine Treatments for Iron Deficiency Anemia
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Objective: This systematic review and meta-analysis were conducted to evaluate the effects of traditional herbal medicine in treating iron deficiency anemia in both adults and children. Methods: Randomized controlled clinical trials conducted between 2013 and 2022, which utilized traditional herbal medicine as an intervention, were included in this study. The China Academic Journal (CAJ) with the CDMD database was used as the primary search source. A meta-analysis was performed on the outcome measures, including hemoglobin levels, serum iron, serum ferritin, and the incidence of adverse effects. Results: In the meta-analysis of studies conducted on adults, the combination therapy group demonstrated a significantly higher hemoglobin (Hb) level compared to the control group, with a mean effect size of 0.71 g/dL (95% CI 0.61~0.81, p<0.00001). Similarly, in the meta-analysis of studies conducted on children, the combination therapy group showed a significantly higher hemoglobin level compared to the control group, with a mean effect size of 1.08 g/dL (95% CI 0.23~1.93, p=0.01). The relative risk (RR) for the incidence of adverse effects in both adults and children was 0.30 (95% CI 0.20~0.45, Z=5.85, p<0.00001), indicating a lower incidence of adverse effects in the combination therapy group. Conclusion: The meta-analyses demonstrated that combining traditional herbal medicine with oral iron supplementation can result in enhanced efficacy for the treatment of iron deficiency anemia. However, this study is limited by the risk of bias in the included studies, the heterogeneity among study populations, and in the herbal formulations across studies.
Abstract
Objective: This systematic review and meta-analysis were conducted to evaluate the effects of traditional herbal medicine in treating iron deficiency anemia in both adults and children. Methods: Randomized controlled clinical trials conducted between 2013 and 2022, which utilized traditional herbal medicine as an intervention, were included in this study. The China Academic Journal (CAJ) with the CDMD database was used as the primary search source. A meta-analysis was performed on the outcome measures, including hemoglobin levels, serum iron, serum ferritin, and the incidence of adverse effects. Results: In the meta-analysis of studies conducted on adults, the combination therapy group demonstrated a significantly higher hemoglobin (Hb) level compared to the control group, with a mean effect size of 0.71 g/dL (95% CI 0.61~0.81, p<0.00001). Similarly, in the meta-analysis of studies conducted on children, the combination therapy group showed a significantly higher hemoglobin level compared to the control group, with a mean effect size of 1.08 g/dL (95% CI 0.23~1.93, p=0.01). The relative risk (RR) for the incidence of adverse effects in both adults and children was 0.30 (95% CI 0.20~0.45, Z=5.85, p<0.00001), indicating a lower incidence of adverse effects in the combination therapy group. Conclusion: The meta-analyses demonstrated that combining traditional herbal medicine with oral iron supplementation can result in enhanced efficacy for the treatment of iron deficiency anemia. However, this study is limited by the risk of bias in the included studies, the heterogeneity among study populations, and in the herbal formulations across studies.
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