A red seaweed, Polysiphonia morrowii, extract promotes β-cell regeneration in zebrasfish (Danio rerio)
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Diabetes Mellitus (DM) is a major health issue increasing worldwide. Currently, nearby half a billion people have diabetes. Two major types of DM that type 1 and type 2-DM have different etiologies but feature a crucial common pathological transition into dysfunction of pancreatic β-cells and consequently leading hyperglycemia and finally go into DM. Therefore, maintaining of β-cells such as preventing β-cells degeneration, and promoting β-cells regeneration and proliferation will be essential approaches in prevention and/or treatment of DM. There are many reports that various types of seaweed control metabolic diseases such as obesity, high blood pressure, and blood sugar control. However, no new drug candidates have been developed yet. Additionally, although seaweed has excellent blood sugar control effects, there is no evidence that it directly proliferates or regenerates beta cells. Therefore, we studied on the promotion of β-cell regeneration by a seaweed, Polysiponia morrowii extract (PME) which preserves β-cells and maintains its function. As a result, it was confirmed that PME directly promotes the proliferation of pancreatic islet β-cells with insulin secretion function in in vivo. Therefore, PME shows potential as a candidate for β-cell regeneration that may play a fundamental role in the treatment of diabetes.
Abstract
Diabetes Mellitus (DM) is a major health issue increasing worldwide. Currently, nearby half a billion people have diabetes. Two major types of DM that type 1 and type 2-DM have different etiologies but feature a crucial common pathological transition into dysfunction of pancreatic β-cells and consequently leading hyperglycemia and finally go into DM. Therefore, maintaining of β-cells such as preventing β-cells degeneration, and promoting β-cells regeneration and proliferation will be essential approaches in prevention and/or treatment of DM. There are many reports that various types of seaweed control metabolic diseases such as obesity, high blood pressure, and blood sugar control. However, no new drug candidates have been developed yet. Additionally, although seaweed has excellent blood sugar control effects, there is no evidence that it directly proliferates or regenerates beta cells. Therefore, we studied on the promotion of β-cell regeneration by a seaweed, Polysiponia morrowii extract (PME) which preserves β-cells and maintains its function. As a result, it was confirmed that PME directly promotes the proliferation of pancreatic islet β-cells with insulin secretion function in in vivo. Therefore, PME shows potential as a candidate for β-cell regeneration that may play a fundamental role in the treatment of diabetes.
참고문헌 (19)
- Brown EM, "Seaweed and human health", Nutr Rev, 72, pp.205~216 (2014)
- Cha SH, "Polysiphonia japonica extract attenuates palmitate-induced toxicity and enhances insulin secretion in pancreatic beta-cells", Oxid Med Cell Longev, 2018, pp.4973851~ (2018)
- Cha SH, "5-Bromoprotocatechualdehyde combats against palmitate toxicity by inhibiting parkin degradation and reducing ROS-induced mitochondrial damage in pancreatic β-cells", Antioxidants, 10, pp.264~ (2021)
- Chaudhury A, "Clinical review of antidiabetic drugs : implications for type 2 diabetes mellitus management", Front Endocrinol, 8, pp.6~ (2017)
- Curado S, "Conditional targeted cell ablation in zebrafish : a new tool for regeneration studies", Dev Dyn, 236, pp.1025~1035 (2007)
- DeFronzo RA, "Type 2 diabetes mellitus", Nat Rev Dis Primers, 1, pp.15019~ (2015)
- "IDF Diabetes Atlas 10th edition" (2021)[URL]
- Jayasinghe AMK, "3-Bromo-4, 5-dihydroxybenzaldehyde isolated from Polysiphonia morrowii suppresses TNF-α", IFN-γ-stimulated inflammation and deterioration of skin barrier in HaCaT keratinocytes, 2022, pp.20, 563~
- Katsarou A, "Type 1 diabetes mellitus", Nat Rev Dis Primers, 3, pp.17016~ (2017)
- Khaliq M, "Stat3 regulates liver progenitor cell-driven liver regeneration in zebrafish", Gene Expr, 18, pp.157~170 (2018)
- Khosla P, "Effect of Trigonella foenum graecum(fenugreek)on blood glucose in normal and diabetic rats", Indian J Physiol Pharmacol, 39, pp.173~174 (1995)
- Kim EA, "Anti-allergic effect of 3, 4-dihydroxybenzaldehyde isolated from Polysiphonia morrowii in IgE", BSA-stimulated mast cells and a passive cutaneous anaphylaxis mouse model, 2022, pp.20, 133~
- Martínez MA, "Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide", Food Chem Toxicol, 156, pp.112460~ (2021)
- Moro E, "Analysis of beta cell proliferation dynamics in zebrafish", Dev Biol, 332, pp.299~308 (2009)
- Roglic G, "WHO Global report on diabetes : a summary", Int J Noncommun Dis, 1, pp.3~8 (2016)
- Sharifuddin Y, "Potential bioactive compounds from seaweed for diabetes management", Mar Drugs, 13, pp.5447~5491 (2015)
- Silva J, "Neuroprotective effects of seaweeds against 6-hydroxidopamine-induced cell death on an in vitro human neuroblastoma model", BMC Complement Altern Med, 18, pp.58~ (2018)
- Tehrani Z, "Endocrine pancreas development in zebrafish", Cell Cycle, 10, pp.3466~3472 (2011)
- Zang L, "Zebrafish as a model for obesity and diabetes", Front Cell Dev Biol, 6, pp.91~ (2018)