Tyrosinase inhibition effects of Korean edible brown, green, and red seaweed extracts
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The tyrosinase inhibition effects of 23 marine-derived seaweeds harvested in Korea were screened to determine their potential as skin-whitening agents. Of the 23 species initially screened, the total phenolic (TP) content of brown, green, and red seaweeds were 7.62–280.11, 5.24–62.37, and 0.63–28.76 phloroglucinol equivalents (PGE) mg/g, respectively. Brown seaweed extracts exhibited much stronger inhibitory activities than green and red seaweed extracts. Among the brown seaweeds, Ecklonia cava had the highest TP content (280.11 PGE mg/g) and the strongest tyrosinase inhibitory effect with a half maximal inhibitory concentration (IC50) value of 4.38 μg/mL. The kinetics of tyrosinase inhibition, analyzed by Lineweaver–Burk plots, found E. cava extract to be a non-competitive inhibitor. This study’s results indicated that E. cava’s inhibition of tyrosinase may have potential applications in the cosmetic industry.
Abstract
The tyrosinase inhibition effects of 23 marine-derived seaweeds harvested in Korea were screened to determine their potential as skin-whitening agents. Of the 23 species initially screened, the total phenolic (TP) content of brown, green, and red seaweeds were 7.62–280.11, 5.24–62.37, and 0.63–28.76 phloroglucinol equivalents (PGE) mg/g, respectively. Brown seaweed extracts exhibited much stronger inhibitory activities than green and red seaweed extracts. Among the brown seaweeds, Ecklonia cava had the highest TP content (280.11 PGE mg/g) and the strongest tyrosinase inhibitory effect with a half maximal inhibitory concentration (IC50) value of 4.38 μg/mL. The kinetics of tyrosinase inhibition, analyzed by Lineweaver–Burk plots, found E. cava extract to be a non-competitive inhibitor. This study’s results indicated that E. cava’s inhibition of tyrosinase may have potential applications in the cosmetic industry.
참고문헌 (25)
- Beaumont KA, "The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking", Traffic, 12, pp.627~643 (2011)
- Blat Y, "Non-competitive inhibition by active site binders", Chem Biol Drug Des, 75, pp.535~540 (2010)
- Costin GE, "Human skin pigmentation : melanocytes modulate skin color in response to stress", FASEB J, 21, pp.976~994 (2007)
- Eom SH, "Enhancement of polyphenol content and antioxidant activity of brown alga Eisenia bicyclis extract by microbial fermentation", Fish Aquat Sci, 14, pp.192~197 (2011)
- Fitzpatrick TB, "The epidermal melanin unit system", Dermatol Wochenschr, 147, pp.481~489 (1963)
- Gómez-Guzmán M, "Potential role of seaweed polyphenols in cardiovascular-associated disorders", Mar Drugs, 16, pp.250~ (2018)
- Hakim MM, "A review on phytoconstituents of marine brown algae", Future J Pharm Sci, 6, pp.129~ (2020)
- Huang HC, "Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways", Chem Biol Interact, 258, pp.166~174 (2016)
- National list of species of Korea: marine algae, "Kim HS", National Institute of Biological Resources Ministry of Environment Korea, 366~ (2013)
- Kim SJ, "Total phenolic contents and biological activities of Korean seaweed extracts", Food Sci Biotechnol, 14, pp.798~802 (2005)
- Ko SC, "Protocatechuic aldehyde inhibits α-MSH-induced melanogenesis in B16F10 melanoma cells via PKA", CREB-associated MITF downregulation, 2021, pp.22, 3861~
- Kondo T, "Update on the regulation of mammalian melanocyte function and skin pigmentation", Expert Rev Dermatol, 6, pp.97~108 (2011)
- Lee SH, "Cellular activities and docking studies of eckol isolated from Ecklonia cava(Laminariales, Phaeophyceae)as potential tyrosinase inhibitor", Algae, 30, pp.163~170 (2015)
- Mabeau S, "Seaweed in food products : biochemical and nutritional aspects", Trends Food Sci Technol, 4, pp.103~107 (1993)
- No JK, "Inhibition of tyrosinase by green tea components", Life Sci, 65, pp.PL241~PL246 (1999)
- Panzella L, "Natural and bioinspired phenolic compounds as tyrosinase inhibitors for the treatment of skin hyperpigmentation : recent advances", Cosmetics, 6, pp.57~ (2019)
- Park J, "Extracts of red seaweed, Pyropia yezoensis, inhibit melanogenesis but stimulate collagen synthesis", J Appl Phycol, 33, pp.653~662 (2021)
- Periaswamy Sivagnanam S, "Biological properties of fucoxanthin in oil recovered from two brown seaweeds using supercritical CO2 extraction", Mar Drugs, 13, pp.3422~3442 (2015)
- Pirian K, "Nutritional and bioactivity evaluation of common seaweed species from the Persian Gulf", Iran J Sci Technol Trans A Sci, 42, pp.1795~1804 (2018)
- Rao AR, "Effective inhibition of skin cancer, tyrosinase, and antioxidative properties by astaxanthin and astaxanthin esters from the green alga Haematococcus pluvialis", J Agric Food Chem, 61, pp.3842~3851 (2013)
- Ryu JW, "α-Amylase and α-glucosidase inhibition effects of Korean edible brown, green, and red seaweed extracts", Fish Aquat Sci, 26, pp.181~187 (2023)
- Shim KB, "Inhibitory effect of fucofuroeckol-a from Eisenia bicyclis on tyrosinase activity and melanin biosynthesis in murine melanoma B16F10 cells", Fish Aquat Sci, 21, pp.35~ (2018)
- Wang L, "Bioactivities of the edible brown seaweed, Undaria pinnatifida : a review", Aquac, 495, pp.873~880 (2018)
- Widyaswari SG, "A review : bioactive compounds of macroalgae and their application as functional beverages", IOP Conf Ser Earth Environ Sci, 679, pp.012002~ (2021)
- Wu PY, "Sesamol inhibited melanogenesis by regulating melanin-related signal transduction in B16F10 cells", Int J Mol Sci, 19, pp.1108~ (2018)