본문 바로가기
KERD
논문KCI 등재

Relationship betw een Pre-treatm ent Serum SCC (squamous cell carcinoma) A ntigen, Cyfra 21-1 Levels, and Survival in Squamous Cell Carcinoma of the Uterine Cervix

Ki-Hong Chang|Hee-Sug Ryu|Suk-Joon Chang|Young-Ji Byun|Jung-Pil Lee
대한암학회 (Korean Cancer Association)|2005.10|Cancer Research and Treatment|제37권 제5호|pp. 302-306

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류의학일반

초록

Abstract

Purpose: To determine the relationship between pretreatment serum squamous cell carcinoma (SCC) antigen and Cyfra 21-1 levels, and survival in patients with invasive squamous cell carcinoma of the cervix. Materials and Methods: One hundred and one cervical squamous cell carcinoma patients were included. Pre-treatment levels of serum SCC antigen and Cyfra 21-1 were measured, with a 5 year minimum follow up. Thirty two recurrent disease (RD) patients were compared to 99 non-recurrent disease (NRD) patients with respect to tumor markers, FIGO stage, lesion size, lymph node status, and parametrial involvement. Results: Pre-treatment serum SCC antigen and Cyfra 21-1 levels were significantly higher in the RD group (p＜ 0.001). Combined serum SCC antigen and Cyfra 21-1 levels showed higher sensitivity for prediction of recurrence (90.6%). Pre-treatment SCC antigen and Cyfra 21-1 levels showed correlation with high FIGO stage, large lesion size, lymph node status, and parametrial involvement (p＜0.001). Normal pre-treatment levels of SCC antigen and Cyfra 21-1 showed a 5-year survival rate of 93% and 90% respectively, while elevated levels showed significantly decreased survival rate of 63% and 59%,respectively (p＜0.001). Odd ratio for cumulative survival rates were 6.87 for SCC antigen, and 5.07 for Cyfra 21-1 (p＜0.001). Conclusion: Initial pre-treatment levels of serum SCC antigen and Cyfra 21-1 are closely related to FIGO stage, lesion size, lymph node and parametrial involvement in patients with squamous cell carcinoma of the cervix. Also, these markers may be of help to predicting recurrent disease and survival rates

참고문헌 (21)

  1. "Tumor markers in gynecologic oncology", 45, pp.94~105 (1990)
  2. "Radioimmunoassay for tumor antigen ofhuman cervical squamous cell carcinoma", 40, pp.1621~8 (1977)
  3. "Cancer of the uterine cervix:sensitivityand specificity of serum squamous cell carcinoma antigendeterminations", 39, pp.186~94 (1990)
  4. "Cytokeratin 19 fragments:a newmarker for non-small-cell lung cancer", 26, pp.301~4 (1993)
  5. "Cytokeratin subunit 19 measured by CYFRA21-1 assay in follow-up of cervical cancer", 56, pp.402~5 (1995)
  6. "Cancer of the uterine cervix: sensitivity and specificity of serumCyfra 21.1 determinations.", 19, pp.50~6 (1998)
  7. "Serum levels of cytokeratin 19 fragments in cervicalcancer", 42, pp.267~70 (1996)
  8. "SCC antigen in the serum as an independentprognostic factor in operable squamous cell carcinoma of thecervix", 38, pp.1987~91 (2002)
  9. "Can initial serum Cyfra 21-1, SCCantigen, and TPA levels in squamous cell cervical cancer predictlymph node metastases or prognosis?", 77, pp.164~70 (2000)
  10. "Application of tumor markers CEA, TPA, and SCC-Ag inpatients with low-risk FIGO stage IB and IIA squamous cellcarcinoma of the uterine cervix.", 76, pp.103~6 (2000)
  11. "Clinical value of pretreatment serum CYFRA 21-1 andSCC Ag levels in cervical cancer patients", 42, pp.2720~5 (1999)
  12. "Pretreatment serum squamous cellcarcinoma antigen:a newly identified prognostic factor inearly-stage cervical carcinoma", 14, pp.111~8 (1996)
  13. "Preoperative serum SCC,CA125,and CA19-9levels and lymph node status in squamous cell carcinoma of theuterine cervix", 81, pp.451~7 (2002)
  14. "Serum tumor markers in the management of ovarian, endometrialand cervical cancer.", 58, pp.24~38 (2004)
  15. "Study of a new tumor marker in squamous cell carcinoma of the cervix andcomparison with squamous cell carcinoma antigen", 43, pp.27~9 (1996)
  16. "Monitoring the course of cervical carcinoma withthe squamous cell carcinoma serum radioimmunoassay", 74, pp.944~9 (1989)
  17. "Cytokeratins of normalepithelia and some neoplasms of the female genital tract", 49, pp.599~610 (1983)
  18. "Prognostic significance of serum fragmentsof cytokeratin 19 measured by Cyfra 21-1 in cervicalcancer", 55, pp.371~5 (1994)
  19. "Value of Cyfra 21-1, TPA, and SCC-Ag in predictingextracervical disease and prognosis in cervical cancer", 17, pp.2955~8 (1997)
  20. "Clinical value of pretreatment serumCyfra 21-1,tissue polypeptide antigen,and squamous cell carcinomaantigen levels in patients with cervical cancer", 76, pp.807~13 (1995)
  21. "Cyfra 21-1 in monitoring cervical cancer: a comparisonwith tissue polypeptide antigen and squamous cellcarcinoma antigen.", 17, pp.2329~34 (1997)

관련 논문AI추천

PROGNOSTIC VALUE OF PRE-TREATMENT SCC-AG LEVEL IN PATIENTS WITH CERVICAL CANCER김병기, 김태중, 박진영, 배덕수, 안정주, 이유영, 이정원, 최철훈대한산부인과학회 · Obstetrics & Gynecology Science2011 · 제54권 제08호Prognostic Value of Different Patterns of Squamous Cell Carcinoma Antigen Level for the Recurrent Cervical Cancer박원, 김병기, 배덕수, 정배권, 최두호, 허승재대한암학회 · Cancer Research and Treatment2013 · 제45권 제1호The prognostic value of squamous cell carcinoma antigen for predicting tumor recurrence in cervical squamous cell carcinoma patients강우대, 김석모, 류현경, 백지선대한산부인과학회 · Obstetrics & Gynecology Science2015 · 제58권 제5호Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with locally advanced cervical cancer treated with radiation or chemoradiation고석봉, 김주현, 오진주, 이태성, 이현주, 최윤석대한산부인과학회 · Obstetrics & Gynecology Science2016 · 제59권 제4호A Preliminary Results of a Randomized Trial Comparing Monthly 5-flourouracil and Cisplatin to Weekly Cisplatin Alone Combined with Concurrent Radiotherapy for Locally Advanced Cervical CancerEun Kyung Choi, Heon Jin Park, Jong Hoon Kim, Joo Hyun Nam, Jung Eun Mok, Sang wook Lee, Seong Soo Shin, Seung Do Ahn, Young Seok Kim, Young Tak Kim대한암학회 · Cancer Research and Treatment2005 · 제37권 제1호Impact of Neoadjuvant Chemotherapy on Postoperative Morbidity in Locally Advanced Cervical CarcinomaMi Suk Kim, Suk Bong Koh, Tae Sung Lee, Youn Seok Choi대한암학회 · Cancer Research and Treatment2002 · 제34권 제3호

이 간행물의 다른 논문 (9건)

Epstein-Barr Virus in Human Malignancy: A Special Reference to Epstein-Barr Virus Associated Gastric Carcinoma김우호, Mee Soo Chungpp. 257-267Results of Curative Radiation Therapy with or without Chemotherapy for Stage III Unresectable Non-Small Cell Lung Cancer남택근, 김영철, 나병식, 안성자, Kyung-Ok Park, 윤미선, 송주영, 김규식, 정웅기pp. 268-272Treatment Outcomes of Three-Dimensional Conformal Radiotherapy for Stage III N on-Small Cell Lung CancerSun-Young Kim, 여승구, Moon-June Cho, Seung-Pyung Lim, Ki-Hwan Kim, Jun-Sang Kimpp. 273-278Oxaliplatin with Biweekly Low Dose Leucovorin and Bolus and Continuous Infusion of 5-fluorouracil (Modified FOLFOX 4) as a Salvage Therapy for Patients w ith Advanced Gastric CancerDong-Mee Lee, 김효진, 김성현, 김재석, 권혁찬, 서성환, Ji-Hoon Jo, Young-Rak Cho, Bong-Gun Seopp. 279-283Combination Chemotherapy of Oxaliplatin, 5-Fluorouracil and Low Dose Leucovorin in Patients with Advanced Colorectal CancerYoung Ook Eum, Seong Woo Lim, Kyung Suck Cheoi, 한혜숙, Byung Chul Kim, 김승택, 이기형, Yoon Mi Shinpp. 284-289
원문 보기