Severe Hypothyroidism Induced by Thyroid Metastasis of Cholangiocarcinoma
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
We report a case of severe hypothyroidism in a cholangiocarcinoma patient with metastasis to the thyroid gland. A 58-year-old man was admitted for upper abdominal discomfort and multiple palpable neck nodules. Abdominal computed tomography (CT) demonstrated the presence of a 4.7-cm tumor in the right hepatic lobe, and core needle biopsy revealed it to be cholangiocarcinoma. Neck CT showed a diffuse, low attenuation thyroid gland, and fine-needle aspiration (FNA) demonstrated metastatic denocarcinoma. Thyroid function tests were initially normal, but the size of the thyroid gland decreased and severe hypothyroidism developed after chemotherapy was implemented for cholangiocarcinoma. In a patient with malignant disease and a goiter, the possibility of a metastatic tumor involving the thyroid should be seriously considered. Metastatic thyroid cancer and thyroid dysfunction are probably infrequent, but diagnosis is important in the institution of appropriate therapy.
Abstract
We report a case of severe hypothyroidism in a cholangiocarcinoma patient with metastasis to the thyroid gland. A 58-year-old man was admitted for upper abdominal discomfort and multiple palpable neck nodules. Abdominal computed tomography (CT) demonstrated the presence of a 4.7-cm tumor in the right hepatic lobe, and core needle biopsy revealed it to be cholangiocarcinoma. Neck CT showed a diffuse, low attenuation thyroid gland, and fine-needle aspiration (FNA) demonstrated metastatic denocarcinoma. Thyroid function tests were initially normal, but the size of the thyroid gland decreased and severe hypothyroidism developed after chemotherapy was implemented for cholangiocarcinoma. In a patient with malignant disease and a goiter, the possibility of a metastatic tumor involving the thyroid should be seriously considered. Metastatic thyroid cancer and thyroid dysfunction are probably infrequent, but diagnosis is important in the institution of appropriate therapy.
참고문헌 (8)
- Kim TY, "Metastasis to the thyroid diagnosed by fine-needle aspiration biopsy", Clin Endocrinol (Oxf), 62, pp.236~241 (2005)
- Nakhjavani MK, "Metastasis to the thyroid gland. A report of 43 cases", Cancer, 79, pp.574~578 (1997)
- Wood K, "Metastases to the thyroid gland: the royal marsden experience", Eur J Surg Oncol, pp.583~588 (2004)
- Eriksson M, "Hyperthyroidism from thyroid metastasis of pancreatic adenocarcinoma", JAMA, 238, pp.1276~1278 (1977)
- Miyakawa M, "Severe thyrotoxicosis induced by thyroid metastasis of lung adenocarcinoma: a case report and review of the literature", Thyroid, 11, pp.883~888 (2001)
- Hull OH, "Critical analysis of two hundred twenty-one thyroid glands; study of thyroid glands obtained at necropsy in Colorado", AMA Arch Pathol, 59, pp.291~311 (1955)
- Abrams HL, "Metastases in carcinoma; analysis of 1,000 autopsied cases", Cancer, 3, pp.74~85 (1950)
- Wychulis AR, "Metastasis of carcinoma to the thyroid gland", Ann Surg, 160, pp.169~177 (1964)