Prognostic Impact of Polymorphisms in the CASPASE Genes on Survival of Patients with Colorectal Cancer
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients. Materials and Methods A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10genes were determined using a reverse transcription polymerase chain reaction genotyping assay. Results The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%)patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival. Conclusion None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.
Abstract
Purpose This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients. Materials and Methods A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10genes were determined using a reverse transcription polymerase chain reaction genotyping assay. Results The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%)patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival. Conclusion None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.
참고문헌 (24)
- Popat S, "Systematic review of microsatellite instability and colorectal cancer prognosis", J Clin Oncol, 23, pp.609~618 (2005)
- Reed JC, "Mechanisms of apoptosis", Am J Pathol, 157, pp.1415~1430 (2000)
- Nagata S, "Apoptosis by death factor", Cell, 88, pp.355~365 (1997)
- Lowe SW, "Apoptosis in cancer", Carcinogenesis, 21, pp.485~495 (2000)
- Evan GI, "Proliferation, cell cycle and apoptosis in cancer", Nature, 411, pp.342~348 (2001)
- Shivapurkar N, "Apoptosis and lung cancer : a review", J Cell Biochem, 88, pp.885~898 (2003)
- Nicholson DW, "Caspases : killer proteases", Trends Biochem Sci, 22, pp.299~306 (1997)
- Budihardjo I, "Biochemical pathways of caspase activation during apoptosis", Annu Rev Cell Dev Biol, 15, pp.269~290 (1999)
- Degterev A, "A decade of caspases", Oncogene, 22, pp.8543~8567 (2003)
- Fuentes-Prior P, "The protein structures that shape caspase activity, specificity, activation and inhibition", Biochem J, 384(Pt 2), pp.201~232 (2004)
- Sun T, "A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers", Nat Genet, 39, pp.605~613 (2007)
- Park JY, "Caspase 9 promoter polymorphisms and risk of primary lung cancer", Hum Mol Genet, 15, pp.1963~1971 (2006)
- Jang JS, "Identification of polymorphisms in the Caspase-3 gene and their association with lung cancer risk", Mol Carcinog, 47, pp.383~390 (2008)
- MacPherson G, "Association of a common variant of the CASP8 gene with reduced risk of breast cancer", J Natl Cancer Inst, 96, pp.1866~1869 (2004)
- Li C, "Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma", Hum Mutat, 29, pp.1443~1451 (2008)
- Frank B, "Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant", Carcinogenesis, 27, pp.606~609 (2006)
- Yoo SS, "Polymorphisms in the CASPASE Genes and Survival in Patients With Early-Stage Non-Small-Cell Lung Cancer", JOURNAL OF CLINICAL ONCOLOGY, 27(34), pp.5823~5829 (2009), AMER SOC CLINICAL ONCOLOGY
- Hamilton SR, "World Health Oorganization classification of tumors. Pathology and genetics: tumours of the digestive system" (2000), IARC Press
- Greene FL, "AJCC cancer staging manual. 6th ed" (2002), Springer-Verlag
- Yuan HY, "FASTSNP: an always up-todate and extendable service for SNP function analysis and prioritization", Nucleic Acids Res, 34(Web Server issue), pp.W635~W641 (2006)
- Son JW, "Polymorphisms in the caspase-8 gene and the risk of lung cancer", Cancer Genetics and Cytogenetics, 169(2), pp.121~127 (2006), Elsevier BV
- Liu B, "Association of selected polymorphisms of CCND1, p21, and caspase8 with colorectal cancer risk", Mol Carcinog, 49, pp.75~84 (2010)
- Kim JG, "Prostaglandin synthase 2", cyclooxygenase 2(PTGS2, Cancer Chemother Pharmacol, pp.2009, 64[DOI]
- Chae YS, "RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 137(4), pp.705~713 (2011), SPRINGER