ERCC1 Can Be a Prognostic Factor in Hilar Cholangiocarcinoma and Extrahepatic Bile Duct Cancer, But Not in Intrahepatic Cholangiocarcinoma
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Purpose There are three types of bile duct cancer, intrahepatic cholangiocarcinoma (ICC),hilar cholangiocarcinoma (HC), and extrahepatic cholangiocarcinoma (EHC). Despite different clinical presentation, the same protocol has been used in treatment of patients with these cancers. We analyzed clinicopathologic findings and protein expression in order to investigate the difference and the specific prognostic factors among these three types of cancers. Materials and Methods We conducted a retrospective review of 104 patients diagnosed with bile duct cancer at Seoul St. Mary’s Hospital between January 1994 and May 2004. We performed immunohistochemical staining for p53, cyclin D1, thymidine phosphorylase, survivin,and excision repair cross-complementing group 1 (ERCC1). Results Of the 104 patients, EHC was most common (44.2%). In pathologic findings,perineural invasion was significantly less common in ICC. Overall survival was similar among the three types of cancer. Lymph node invasion, lymphatic, and venous invasion showed a significant association with survival outcome in ICC, however, the differentiation of histologic grade had prognostic significance in HC and EHC. No difference in protein expression was observed among these types of cancer, however,ERCC1 showed a significant association with survival outcome in HC and EHC, not in ICC. Conclusion Based on our data, ICC showed different characteristics and prognostic factors,separate from the other two types of bile duct cancer. Conduct of further studies with a large sample size is required in order to confirm these data.
Abstract
Purpose There are three types of bile duct cancer, intrahepatic cholangiocarcinoma (ICC),hilar cholangiocarcinoma (HC), and extrahepatic cholangiocarcinoma (EHC). Despite different clinical presentation, the same protocol has been used in treatment of patients with these cancers. We analyzed clinicopathologic findings and protein expression in order to investigate the difference and the specific prognostic factors among these three types of cancers. Materials and Methods We conducted a retrospective review of 104 patients diagnosed with bile duct cancer at Seoul St. Mary’s Hospital between January 1994 and May 2004. We performed immunohistochemical staining for p53, cyclin D1, thymidine phosphorylase, survivin,and excision repair cross-complementing group 1 (ERCC1). Results Of the 104 patients, EHC was most common (44.2%). In pathologic findings,perineural invasion was significantly less common in ICC. Overall survival was similar among the three types of cancer. Lymph node invasion, lymphatic, and venous invasion showed a significant association with survival outcome in ICC, however, the differentiation of histologic grade had prognostic significance in HC and EHC. No difference in protein expression was observed among these types of cancer, however,ERCC1 showed a significant association with survival outcome in HC and EHC, not in ICC. Conclusion Based on our data, ICC showed different characteristics and prognostic factors,separate from the other two types of bile duct cancer. Conduct of further studies with a large sample size is required in order to confirm these data.
참고문헌 (24)
- Malhi H, "Cholangiocarcinoma: modern advances in understanding a deadly old disease", J Hepatol, 45, pp.856~867 (2006)
- Okabayashi T, "A new staging system for mass-forming intrahepatic cholangiocarcinoma: analysis of preoperative and postoperative variables", Cancer, 92, pp.2374~2383 (2001)
- Weber A, "Longterm outcome and prognostic factors of patients with hilar cholangiocarcinoma", World J Gastroenterol, 13, pp.1422~1426 (2007)
- Sano T, "Prognosis of perihilar cholangiocarcinoma: hilar bile duct cancer versus intrahepatic cholangiocarcinoma involving the hepatic hilu", Ann Surg Oncol, 15, pp.590~599 (2008)
- Aishima S, "Proposal of progression model for intrahepatic cholangiocarcinoma: clinicopathologic differences between hilar type and peripheral type", Am J Surg Pathol, 31, pp.1059~1067 (2007)
- Hong SM, "Clinical and prognostic significances of nuclear and cytoplasmic KIT expressions in extrahepatic bile duct carcinomas", Mod Pathol, 20, pp.562~569 (2007)
- Arora DS, "p53 but not bcl-2 is expressed by most cholangiocarcinomas: a study of 28 cases", Histopathology, 34, pp.497~501 (1999)
- Rashid A, "K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China", Clin Cancer Res, 8, pp.3156~3163 (2002)
- Thanasai J, "Effects of thymidine phosphorylase on tumor aggressiveness and 5-fluorouracil sensitivity in cholangiocarcinoma", World J Gastroenterol, 16, pp.1631~1638 (2010)
- Nakeeb A, "Cholangiocarcinoma: a spectrum of intrahepatic, perihilar, and distal tumors", Ann Surg, 224, pp.463~473 (1996)
- Aljiffry M, "Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009", World J Gastroenterol, 15, pp.4240~4262 (2009)
- Cereda S, "Adjuvant treatment in biliary tract cancer: to treat or not to treat", World J Gastroenterol, 18, pp.2591~2596 (2012)
- Shirai K, "Perineural invasion is a prognostic factor in intrahepatic cholangiocarcinoma", World J Surg, 32, pp.2395~2402 (2008)
- Suzuki S, "Clinicopathological prognostic factors and impact of surgical treatment of mass-forming intrahepatic cholangiocarcinoma", World J Surg, 26, pp.687~693 (2002)
- Tajima Y, "An intraductal papillary component is associated with prolonged survival after hepatic resection for intrahepatic cholangiocarcinoma", Br J Surg, 91, pp.99~104 (2004)
- Guedj N, "Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas", J Hepatol, 51, pp.93~101 (2009)
- de Jong MC, "Intrahepatic cholangiocarcinoma: an international multiinstitutional analysis of prognostic factors and lymph node assessment", J Clin Oncol, 29, pp.3140~3145 (2011)
- Kim WB, "Expression and clinical significance of cell cycle regulatory proteins in gallbladder and extrahepatic bile duct cancer", Ann Surg Oncol, 16, pp.23~34 (2009)
- Wang J, "p53 status and its prognostic role in extrahepatic bile duct cancer: a meta-analysis of published studies", Dig Dis Sci, 56, pp.655~662 (2011)
- Jarnagin WR, "Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: correlation with anatomic site, pathologic variables, and clinical outcome", J Clin Oncol, 24, pp.1152~1160 (2006)
- Gossage L, "Current status of excision repair cross complementing- group 1 (ERCC1) in cancer", Cancer Treat Rev, 33, pp.565~577 (2007)
- Toi M, "Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatment", Lancet Oncol, 6, pp.158~166 (2005)
- Aishima S, "The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma", Int J Surg Pathol, 10, pp.47~56 (2002)
- Javle MM, "Nuclear survivin expression predicts poor outcome in cholangiocarcinoma", Hepatogastroenterology, 51, pp.1653~1657 (2004)