The Efficacy of External Beam Radiotherapy for Airway Obstruction in Lung Cancer Patients
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Purpose The objective of this study was to evaluate external beam radiotherapy (EBRT) in lung cancerpatients who suffer from airway obstruction. Materials and MethodsMedical data of 95 patients with a lung mass that obstructed the airway and received EBRTfor it were analyzed. Fifty-nine patients (62.1%) had non-small cell lung cancer and 36patients (37.9%) had small cell lung cancer. Radiotherapy was given at 8 to 45 Gy (median,30 Gy) in 1 to 15 fractions (median, 10 fractions). The response to EBRT was assessedthrough changes in radiographic findings and/or subjective symptoms between before andafter EBRT. The median follow-up duration was 124 days. The primary end point was theairway-obstruction resolving rate after EBRT. The secondary end points were patient survivaland toxic effects of EBRT. ResultsImprovement of airway obstruction after EBRT on chest X-ray was achieved in 75 of 95patients (78.9%). The median time for resolving the radiologic findings and/or symptomsof airway obstruction after EBRT was 7 days (range, 1 to 76 days). The 1-year survival ratewas significantly higher in responders than non-responders (12.5% vs. 0.0%, p < 0.001). The biologically effective dose of 39 Gy/=10 (p < 0.01) and the longest obstructive lesionof < 6 cm (p=0.04) were significantly associated with a good response to EBRT in resolvingthe airway obstruction. No one had grade 3 or higher acute and chronic toxicities. ConclusionEBRT is an effective treatment in relieving airway obstruction without severe toxicities inlung cancer patients.
Abstract
Purpose The objective of this study was to evaluate external beam radiotherapy (EBRT) in lung cancerpatients who suffer from airway obstruction. Materials and MethodsMedical data of 95 patients with a lung mass that obstructed the airway and received EBRTfor it were analyzed. Fifty-nine patients (62.1%) had non-small cell lung cancer and 36patients (37.9%) had small cell lung cancer. Radiotherapy was given at 8 to 45 Gy (median,30 Gy) in 1 to 15 fractions (median, 10 fractions). The response to EBRT was assessedthrough changes in radiographic findings and/or subjective symptoms between before andafter EBRT. The median follow-up duration was 124 days. The primary end point was theairway-obstruction resolving rate after EBRT. The secondary end points were patient survivaland toxic effects of EBRT. ResultsImprovement of airway obstruction after EBRT on chest X-ray was achieved in 75 of 95patients (78.9%). The median time for resolving the radiologic findings and/or symptomsof airway obstruction after EBRT was 7 days (range, 1 to 76 days). The 1-year survival ratewas significantly higher in responders than non-responders (12.5% vs. 0.0%, p < 0.001). The biologically effective dose of 39 Gy/=10 (p < 0.01) and the longest obstructive lesionof < 6 cm (p=0.04) were significantly associated with a good response to EBRT in resolvingthe airway obstruction. No one had grade 3 or higher acute and chronic toxicities. ConclusionEBRT is an effective treatment in relieving airway obstruction without severe toxicities inlung cancer patients.
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